在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human F-box only protein 25 (FBXO25)

  • 中文名稱:
    人FBXO25重組蛋白
  • 貨號:
    CSB-YP848401HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人FBXO25重組蛋白
  • 貨號:
    CSB-EP848401HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人FBXO25重組蛋白
  • 貨號:
    CSB-EP848401HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人FBXO25重組蛋白
  • 貨號:
    CSB-BP848401HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人FBXO25重組蛋白
  • 貨號:
    CSB-MP848401HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    F box only protein 25; F box protein 25; F box protein Fbx25; F-box only protein 25; FBX25 ; FBX25_HUMAN; FBXO25; MGC20256; MGC51975; OTTHUMP00000115399
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-367
  • 氨基酸序列
    MPFLGQDWRS PGWSWIKTED GWKRCESCSQ KLERENNRCN ISHSIILNSE DGEIFNNEEH EYASKKRKKD HFRNDTNTQS FYREKWIYVH KESTKERHGY CTLGEAFNRL DFSSAIQDIR RFNYVVKLLQ LIAKSQLTSL SGVAQKNYFN ILDKIVQKVL DDHHNPRLIK DLLQDLSSTL CILIRGVGKS VLVGNINIWI CRLETILAWQ QQLQDLQMTK QVNNGLTLSD LPLHMLNNIL YRFSDGWDII TLGQVTPTLY MLSEDRQLWK KLCQYHFAEK QFCRHLILSE KGHIEWKLMY FALQKHYPAK EQYGDTLHFC RHCSILFWKD YHLALLFKDS GHPCTAADPD SCFTPVSPQH FIDLFKF
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT).
  • 基因功能參考文獻:
    1. Taken together we show that FBXO25 functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation. PMID: 28389297
    2. High FBXO25 expression is associated with non-small-cell lung cancer. PMID: 27596142
    3. FBXO25 functions as a haploinsufficient tumor suppressor in mantle cell lymphoma. PMID: 25419709
    4. FBXO25 mediates ELK-1 degradation through the ubiquitin proteasome system and thereby plays a role in regulating the activation of ELK-1 pathway in response to mitogens PMID: 23940030
    5. Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5, Isl1, and Hand1, indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development. PMID: 21596019
    6. Beta-actin, physically interacts through its N-terminus with FBXO25 and is enriched in the FBXO25 nuclear compartments. PMID: 20473970
    7. investigated hFBX25's genomic organization and established hFBX25 as an FBP by verifying its interaction with Skp1 and Cul1 PMID: 16278047
    8. The cellular distribution of FBXO25 and its colocalization with some nuclear proteins is investigated by using immunochemical and biochemical approaches. PMID: 18287534

    顯示更多

    收起更多

  • 相關疾病:
    A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with SHROOM4.
  • 亞細胞定位:
    Nucleus. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.
  • 組織特異性:
    Expressed in all brain tissue observed.
  • 數據庫鏈接:

    HGNC: 13596

    OMIM: 609098

    KEGG: hsa:26260

    STRING: 9606.ENSP00000276326

    UniGene: Hs.438454



主站蜘蛛池模板: 国产特级毛片aaaaaa毛片| 成人做爰视频www| 亚洲国产av无码精品| 亚洲永久精品ww47| 无码高潮又爽又黄a片日本动漫| 久久久婷婷五月亚洲97色| 欧美日韩中文国产一区发布| 欧美性生交大片18禁止| 真实国产乱子伦视频| 亚洲欧美日韩愉拍自拍美利坚 | 女人扒开屁股桶爽30分钟| 日韩激情无码免费毛片| 巨大乳做爰视频在线看| 人妻系列影片无码专区| 久久av高清无码| 色综合av综合无码综合网站| 中文无码伦av中文字幕在线| 男女啪啪高清无遮挡免费| 99久久久精品免费观看国产| 波多野结衣一区二区三区高清av| 国产情侣草莓视频在线| 久久午夜无码鲁丝片直播午夜精品| 人禽伦免费交视频播放| 在线 | 一区二区三区| 色综合天天综合天天更新| 人人爽人人澡人人人人妻| 四虎国产精品永久在线观看| 亚洲国产另类久久久精品黑人 | 在线看片无码永久av| 99久久无码一区人妻a黑| 中文午夜人妻无码看片| 日韩欧美在线综合网| 又黄又爽又色的视频| 综合无码精品人妻一区二区三区| 国产在线拍揄自揄拍免费下载 | 亚洲成av人最新无码| 粉嫩少妇内射浓精videos| 久久综合给综合给久久| 亚洲一线产区二线产区分布| 四虎影视在线观看2413| 在线精品一区二区三区|