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  4. FBXO25 Antibody, HRP conjugated

FBXO25 Antibody, HRP conjugated

  • 中文名稱：
    FBXO25兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA848401LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FBXO25 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    F box only protein 25 antibody; F box protein 25 antibody; F box protein Fbx25 antibody; F-box only protein 25 antibody; FBX25 antibody; FBX25_HUMAN antibody; FBXO25 antibody; MGC20256 antibody; MGC51975 antibody; OTTHUMP00000115399 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human F-box only protein 25 protein (1-291AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT).
  • 基因功能參考文獻：
    1. Taken together we show that FBXO25 functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation. PMID: 28389297
    2. High FBXO25 expression is associated with non-small-cell lung cancer. PMID: 27596142
    3. FBXO25 functions as a haploinsufficient tumor suppressor in mantle cell lymphoma. PMID: 25419709
    4. FBXO25 mediates ELK-1 degradation through the ubiquitin proteasome system and thereby plays a role in regulating the activation of ELK-1 pathway in response to mitogens PMID: 23940030
    5. Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5, Isl1, and Hand1, indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development. PMID: 21596019
    6. Beta-actin, physically interacts through its N-terminus with FBXO25 and is enriched in the FBXO25 nuclear compartments. PMID: 20473970
    7. investigated hFBX25's genomic organization and established hFBX25 as an FBP by verifying its interaction with Skp1 and Cul1 PMID: 16278047
    8. The cellular distribution of FBXO25 and its colocalization with some nuclear proteins is investigated by using immunochemical and biochemical approaches. PMID: 18287534

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  • 相關疾?。?/div>
    A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with SHROOM4.
  • 亞細胞定位：
    Nucleus. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.
  • 組織特異性：
    Expressed in all brain tissue observed.
  • 數據庫鏈接：

    HGNC: 13596

    OMIM: 609098

    KEGG: hsa:26260

    STRING: 9606.ENSP00000276326

    UniGene: Hs.438454



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