在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Exostosin-like 3 (EXTL3), partial

Recombinant Human Exostosin-like 3 (EXTL3), partial

  • 中文名稱：
    人EXTL3重組蛋白
  • 貨號：
    CSB-YP007905HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人EXTL3重組蛋白
  • 貨號：
    CSB-EP007905HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人EXTL3重組蛋白
  • 貨號：
    CSB-EP007905HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人EXTL3重組蛋白
  • 貨號：
    CSB-BP007905HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人EXTL3重組蛋白
  • 貨號：
    CSB-MP007905HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    EXTL3
  • Uniprot No.：
  • 別名：
    botv; DKFZp686C2342; Exostoses (multiple)-like 3; Exostoses-like 3; Exostosin-like 3; EXT-related protein 1; EXTL1L; EXTL3; EXTL3_HUMAN; EXTR1; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferas; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Hereditary multiple exostoses gene isolog; KIAA0519; Multiple exostosis-like protein 3; Putative tumor suppressor protein EXTL3; REG; Reg receptor; REGR; RPR
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation.
  • 基因功能參考文獻：
    1. Human lumenal N-glycosylated EXTL3 (EXTL3DeltaN) was cloned, expressed in human embryonic kidney cells, and purified. Various biophysical and biochemical approaches were then employed to elucidate the N-glycosylation sites and the function of their attached N-glycans. PMID: 29346724
    2. EXTL3 missense mutation is associated with spondylo-epi-metaphyseal dysplasia. PMID: 28331220
    3. EXTL3 mutations as a novel cause of severe immune deficiency with skeletal dysplasia and developmental delay and underline a crucial role of HS in thymopoiesis and skeletal and brain development. PMID: 28148688
    4. We show that biallelic mutations in EXTL3 disturb glycosaminoglycan synthesis and thus lead to a recognizable syndrome characterized by variable expression of skeletal, neurological, and immunological abnormalities. PMID: 28132690
    5. Recombinant EXTL2 showed weak ability to transfer N-acetylgalactosamine to heparan sulfate precursor molecules but also, that EXTL2 exhibited much stronger in vitro N-acetylglucosamine-transferase activity related to elongation of heparan sulfate chains. PMID: 25829497
    6. Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor. PMID: 22158612
    7. Lysosomal glycosaminoglycan levels in mucopolysaccharidosis are reduced by EXTL3 gene silencing. PMID: 19690583
    8. We conclude that EXTL3 promoter methylation and its related loss of EXTL3 expression are involved in the loss of HS expression in mucinous CRCs. PMID: 18543267
    9. HIP enhanced EXTL3 translocation from the membrane to the nucleus, in support of a model whereby EXTL3 mediates HIP signaling for islet neogenesis. PMID: 19158046
    10. A missense mutation involving the exon 3 of the EXTL3 gene in the case of obstructing colon cancer is described in a 31-year-old patient affected by hereditary multiple exostoses. PMID: 19653241
    11. These results suggest that EXTL3/EXTR1 is a cell surface Reg receptor that binds to Reg protein. PMID: 10753861

    顯示更多

    收起更多

  • 相關疾病：
    Immunoskeletal dysplasia with neurodevelopmental abnormalities (ISDNA)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus.
  • 蛋白家族：
    Glycosyltransferase 47 family
  • 組織特異性：
    Ubiquitous. Expressed in keratinocytes.
  • 數據庫鏈接：

    HGNC: 3518

    OMIM: 605744

    KEGG: hsa:2137

    STRING: 9606.ENSP00000220562

    UniGene: Hs.491354



主站蜘蛛池模板： 午夜影视啪啪免费体验区入口| 国产精品久久久久久福利| 久久伊人蜜桃av一区二区| 麻豆果冻传媒精品| 一区二区三区四区在线 | 中国| 韩国精品久久久久久无码| 内射人妻无码色ab麻豆| 香蕉视频在线观看亚洲| 女人18毛片水真多免费看| 日韩精品一区二区大桥未久 | 午夜亚洲国产理论片二级港台二级| 人人妻人人澡人人爽人人精品| 女人张开腿让男桶喷水高潮| 久久99精品国产自在现线小黄鸭| 国产欧美在线亚洲一区| 激情综合色五月丁香六月欧美| 中文综合在线观| 自拍校园亚洲欧美另类| 久久www免费人成看片入口| 久久无码人妻影院| 国内大量揄拍人妻精品視頻| 亚洲性人人天天夜夜摸18禁止| 久久精品无码av| 欧洲精品码一区二区三区| 日韩高清亚洲日韩精品一区| 噜噜色综合天天综合网mp3| 在线观看免费人成视频| 无码人妻精品一区二区蜜桃网站| а√天堂www在线а√天堂资源| 蜜臀av999无码精品国产专区 | 麻豆国产av丝袜白领传媒| 内射极品少妇xxxxxhd| 亚洲精品美女久久久久99| 日韩内射美女片在线观看网站| 99久久99久久精品免费观看| 久久久久se色偷偷亚洲精品av| 黑人巨大无码中文字幕无码| 国产高清在线a免费视频观看| 欧美黑人巨大xxxxx| 中文字幕一二三区波多野结衣| 日本日本熟妇中文在线视频|