在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EXTL3 Antibody

  • 中文名稱:
    EXTL3兔多克隆抗體
  • 貨號:
    CSB-PA007905GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    EXTL3
  • 別名:
    botv antibody; DKFZp686C2342 antibody; Exostoses (multiple)-like 3 antibody; Exostoses-like 3 antibody; Exostosin-like 3 antibody; EXT-related protein 1 antibody; EXTL1L antibody; EXTL3 antibody; EXTL3_HUMAN antibody; EXTR1 antibody; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferas antibody; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase antibody; Hereditary multiple exostoses gene isolog antibody; KIAA0519 antibody; Multiple exostosis-like protein 3 antibody; Putative tumor suppressor protein EXTL3 antibody; REG antibody; Reg receptor antibody; REGR antibody; RPR antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human EXTL3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation.
  • 基因功能參考文獻:
    1. Human lumenal N-glycosylated EXTL3 (EXTL3DeltaN) was cloned, expressed in human embryonic kidney cells, and purified. Various biophysical and biochemical approaches were then employed to elucidate the N-glycosylation sites and the function of their attached N-glycans. PMID: 29346724
    2. EXTL3 missense mutation is associated with spondylo-epi-metaphyseal dysplasia. PMID: 28331220
    3. EXTL3 mutations as a novel cause of severe immune deficiency with skeletal dysplasia and developmental delay and underline a crucial role of HS in thymopoiesis and skeletal and brain development. PMID: 28148688
    4. We show that biallelic mutations in EXTL3 disturb glycosaminoglycan synthesis and thus lead to a recognizable syndrome characterized by variable expression of skeletal, neurological, and immunological abnormalities. PMID: 28132690
    5. Recombinant EXTL2 showed weak ability to transfer N-acetylgalactosamine to heparan sulfate precursor molecules but also, that EXTL2 exhibited much stronger in vitro N-acetylglucosamine-transferase activity related to elongation of heparan sulfate chains. PMID: 25829497
    6. Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor. PMID: 22158612
    7. Lysosomal glycosaminoglycan levels in mucopolysaccharidosis are reduced by EXTL3 gene silencing. PMID: 19690583
    8. We conclude that EXTL3 promoter methylation and its related loss of EXTL3 expression are involved in the loss of HS expression in mucinous CRCs. PMID: 18543267
    9. HIP enhanced EXTL3 translocation from the membrane to the nucleus, in support of a model whereby EXTL3 mediates HIP signaling for islet neogenesis. PMID: 19158046
    10. A missense mutation involving the exon 3 of the EXTL3 gene in the case of obstructing colon cancer is described in a 31-year-old patient affected by hereditary multiple exostoses. PMID: 19653241
    11. These results suggest that EXTL3/EXTR1 is a cell surface Reg receptor that binds to Reg protein. PMID: 10753861

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Immunoskeletal dysplasia with neurodevelopmental abnormalities (ISDNA)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus.
  • 蛋白家族:
    Glycosyltransferase 47 family
  • 組織特異性:
    Ubiquitous. Expressed in keratinocytes.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3518

    OMIM: 605744

    KEGG: hsa:2137

    STRING: 9606.ENSP00000220562

    UniGene: Hs.491354



主站蜘蛛池模板: 欧美国产日产一区二区| 狠狠综合久久综合88亚洲| 亚洲精品国产suv一区88| 日韩精品毛片无码一区到三区| 韩国无码av片在线观看| 丰满少妇被粗大猛烈进人高清| 欧美真人性做爰一二区| 精品人妻一区二区三区浪潮在线| 国产真实露脸乱子伦原著| 久久亚洲国产最新网站之一| 日本免费高清一本视频| 欧洲无线码免费一区| 国产aⅴ精品一区二区三区尤物| 久久和欧洲码一码二码三码| 亚洲人成网站18禁止大app| 精品一区二区三区无码免费直播 | 伊人中文字幕无码专区| 欧美精品无码一区二区三区| 成人精品视频一区二区三区| 非洲黑人性xxxx精品| 日本熟妇厨房bbw| 少妇一边呻吟一边说使劲视频| 久久亚洲精品国产亚洲老地址| 成 人 a v免费视频在线观看 | 男女猛烈无遮挡免费视频在线观看| 一本色道久久综合无码人妻| 丰满岳乱妇在线观看中字| 午夜成人亚洲理论片在线观看| 天天躁日日躁狠狠躁性色avq| 日本十八禁视频无遮挡| 夜夜春亚洲嫩草影院| 鲁鲁网亚洲站内射污| 久久久久久九九99精品| 成人无码视频在线观看大全| 人人妻人人澡人人爽偷拍台湾| 少妇的肉体在线观看| 欧美gv在线观看| 免费看女人与公拘交酡过程| 国产久久精品| 免费观看又色又爽又黄的韩国| 大香伊蕉在人线国产最新75|