在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Exosome complex exonuclease RRP44 (DIS3), partial

  • 中文名稱:
    人DIS3重組蛋白
  • 貨號:
    CSB-YP897532HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人DIS3重組蛋白
  • 貨號:
    CSB-EP897532HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人DIS3重組蛋白
  • 貨號:
    CSB-EP897532HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人DIS3重組蛋白
  • 貨號:
    CSB-BP897532HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人DIS3重組蛋白
  • 貨號:
    CSB-MP897532HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    2810028N01Rik; bA555G22; Dis3; DIS3 homolog; exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control homolog (S. cerevisiae); DIS3 mitotic control homolog; DIS3 mitotic control; S. cerevisiae; homolog of; dis3p; EXOSC11; Exosome complex exonuclease RRP44; exosome component 11; KIAA1008; Mitotic control protein dis3 homolog ; Protein DIS3 homolog; Ribosomal RNA processing protein 44 ; Ribosomal RNA processing protein 44; S. cerevisiae; homolog of; Ribosomal RNA-processing protein 44; RP11-342J4.3; RRP44 ; RRP44_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
  • 基因功能參考文獻:
    1. The 3.8 A resolution cryo-EM structure of the core complex bound to a single-stranded RNA reveals that the RNA channel path is formed by two distinct features of the hDIS3 exoribonuclease: an open conformation and a domain organization more similar to bacterial RNase II than to yeast Rrp44. PMID: 30047866
    2. Results from a study on gene variability markers in early-stage human embryos shows that DIS3 is a putative variability marker for the 3-day, 8-cell embryo stage, identified by mixture models as well as standard ANOVA. PMID: 26288249
    3. Authors have identified a putative functional indel variant at chr13q22.1 that associates with decreased DIS3 expression in carriers of pancreatic cancer risk-increasing alleles, and could therefore affect nuclear RNA processing and/or decay. PMID: 28172817
    4. Data indicate the pathological relevance of exosome component 11 protein (DIS3) mutations in plasma cell dyscrasias and suggest that DIS3 may represent a potential tumor suppressor gene in such disorders. PMID: 26305418
    5. structure and function of DIS3 PMID: 26193331
    6. The study establishes that the ribonuclease DIS3, targeting LIN28B, sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation. PMID: 25925570
    7. seven novel somatic DIS3 single nucleotide variants (SNVs) and defined three hot spot mutations within the RNB domain. PMID: 25521164
    8. Overexpression of DIS3 and LRCH1 associated with adenoma to carcinoma progression is linked to the colorectal cancer specific gain of 13q. PMID: 24478024
    9. Multiple myeloma-associated hDIS3 mutations interfere with hDIS3 exonucleolytic activity. PMID: 24150935
    10. Data show that hDIS3 and hDIS3L are active exonucleases, but only hDIS3 has retained endonucleolytic activity, and suggest that three different ribonucleases can serve as catalytic subunits for the exosome in human cells. PMID: 20531386
    11. S. cerevisiae Dis3p is identical to Rrp44p, which comprises the exosome involved in ribosomal RNA processing, S. cerevisiae Dis3p was found to be localized in the nucleolus. PMID: 9562621
    12. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. There appears to be no interaction between human dis3 and other exosome subunits, however. PMID: 12419256
    13. Dis3p is identical to Rrp44p, which comprises the exosome involved in ribosomal RNA processing. Similar to S. cerevisiae Dis3p, human Dis3p enhanced RCC1-stimulated nucleotide release from Ran, in a dose-dependent manner, and bound to GTP- or GDP-Ran. PMID: 9562621

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.
  • 蛋白家族:
    RNR ribonuclease family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 20604

    OMIM: 607533

    KEGG: hsa:22894

    STRING: 9606.ENSP00000366997

    UniGene: Hs.744104



主站蜘蛛池模板: 日本高清www无色夜在线视频| 麻豆亚洲国产成人精品无码区| 久久综合五月丁香久久激情 | 狠狠色噜噜狠狠色综合久| 伊人成伊人成综合网222| 人妻无码中文专区久久五月婷 | 色135综合网| 亚洲成在人线av无码| 国内精品久久久久影院中文字幕| 麻豆精品久久久久久中文字幕无码| 又色又爽又高潮免费视频观看| 无遮挡国产高潮视频免费观看 | 中文字幕乱码久久午夜不卡| 亚洲hdmi高清线| 丁香激情综合久久伊人久久| 中文字幕亚洲乱码熟女一区二区| 国产成人亚洲日韩欧美| 亚洲精品久久久久久动漫| 搡老熟女老女人一区二区| 2017亚洲天堂最新地址| 手机看片精品国产福利| 久久av无码精品人妻出轨 | 中文天堂网www新版资源在线| 国产色在线 | 亚洲| 粉嫩虎白女毛片人体| 成在人线无码aⅴ免费视频| 欧美激情a∨在线视频播放| 亚洲国产综合无码一区| 一二三四观看视频社区在线| 欧美群妇大交群| 免费大黄网站在线观| 精品国产丝袜自在线拍国语| 潮喷大喷水系列无码| 午夜dv内射一区区| 久久综合九色综合97网| 免费女人18毛片a毛片视频| a亚洲va欧美va国产综合| 国产亚洲精品久久久久久久软件 | 国产成人精品日本亚洲18| 国产精品 中文字幕 亚洲 欧美| 国精产品999国精产品官网|