在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DIS3 Antibody

  • 中文名稱:
    DIS3兔多克隆抗體
  • 貨號:
    CSB-PA006911GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    2810028N01Rik antibody; bA555G22 antibody; Dis3 antibody; DIS3 homolog; exosome endoribonuclease and 3'-5' exoribonuclease antibody; DIS3 mitotic control homolog (S. cerevisiae) antibody; DIS3 mitotic control homolog antibody; DIS3 mitotic control; S. cerevisiae; homolog of antibody; dis3p antibody; EXOSC11 antibody; Exosome complex exonuclease RRP44 antibody; exosome component 11 antibody; KIAA1008 antibody; Mitotic control protein dis3 homolog antibody; Protein DIS3 homolog antibody; Ribosomal RNA processing protein 44 antibody; Ribosomal RNA processing protein 44; S. cerevisiae; homolog of antibody; Ribosomal RNA-processing protein 44 antibody; RP11-342J4.3 antibody; RRP44 antibody; RRP44_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DIS3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
  • 基因功能參考文獻:
    1. The 3.8 A resolution cryo-EM structure of the core complex bound to a single-stranded RNA reveals that the RNA channel path is formed by two distinct features of the hDIS3 exoribonuclease: an open conformation and a domain organization more similar to bacterial RNase II than to yeast Rrp44. PMID: 30047866
    2. Results from a study on gene variability markers in early-stage human embryos shows that DIS3 is a putative variability marker for the 3-day, 8-cell embryo stage, identified by mixture models as well as standard ANOVA. PMID: 26288249
    3. Authors have identified a putative functional indel variant at chr13q22.1 that associates with decreased DIS3 expression in carriers of pancreatic cancer risk-increasing alleles, and could therefore affect nuclear RNA processing and/or decay. PMID: 28172817
    4. Data indicate the pathological relevance of exosome component 11 protein (DIS3) mutations in plasma cell dyscrasias and suggest that DIS3 may represent a potential tumor suppressor gene in such disorders. PMID: 26305418
    5. structure and function of DIS3 PMID: 26193331
    6. The study establishes that the ribonuclease DIS3, targeting LIN28B, sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation. PMID: 25925570
    7. seven novel somatic DIS3 single nucleotide variants (SNVs) and defined three hot spot mutations within the RNB domain. PMID: 25521164
    8. Overexpression of DIS3 and LRCH1 associated with adenoma to carcinoma progression is linked to the colorectal cancer specific gain of 13q. PMID: 24478024
    9. Multiple myeloma-associated hDIS3 mutations interfere with hDIS3 exonucleolytic activity. PMID: 24150935
    10. Data show that hDIS3 and hDIS3L are active exonucleases, but only hDIS3 has retained endonucleolytic activity, and suggest that three different ribonucleases can serve as catalytic subunits for the exosome in human cells. PMID: 20531386
    11. S. cerevisiae Dis3p is identical to Rrp44p, which comprises the exosome involved in ribosomal RNA processing, S. cerevisiae Dis3p was found to be localized in the nucleolus. PMID: 9562621
    12. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. There appears to be no interaction between human dis3 and other exosome subunits, however. PMID: 12419256
    13. Dis3p is identical to Rrp44p, which comprises the exosome involved in ribosomal RNA processing. Similar to S. cerevisiae Dis3p, human Dis3p enhanced RCC1-stimulated nucleotide release from Ran, in a dose-dependent manner, and bound to GTP- or GDP-Ran. PMID: 9562621

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.
  • 蛋白家族:
    RNR ribonuclease family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 20604

    OMIM: 607533

    KEGG: hsa:22894

    STRING: 9606.ENSP00000366997

    UniGene: Hs.744104



主站蜘蛛池模板: 久久er99国产精品免费| 肉体裸交137日本大胆摄影| 137日本免费肉体摄影| 久久视热这里只有精品| 国产又色又爽又黄的视频在线| 久久国产中文娱乐网| 国产乱人对白| 国产成人免费97在线观看| 日本无码人妻精品一区二区蜜桃| 亚洲中文有码字幕日本| 久久久97丨国产人妻熟女| 亚洲人ⅴsaⅴ国产精品| 麻豆av福利av久久av| 在线播放无码后入内射少妇| 亚洲成a∧人片在线观看无码| 男人吃奶摸下挵进去好爽| 成人亚洲国产精品一区不卡| 成人av无码一区二区三区 | 无码一区二区三区在线观看| 怡春院国产精品视频| 成人a大片在线观看| 亚洲嫩模喷白浆在线观看| 亚洲视频一区| 日本乱妇乱子视频网站-百度| 国产美足白丝榨精在线观看sm| 国内精品乱码卡一卡2卡三卡新区| 久久精品人人做人人爱爱漫画| 少妇激情一区二区三区视频小说| 色偷偷av男人的天堂| 国产精品鲁鲁鲁| 在线观看片免费人成视频无码| 文中字幕一区二区三区视频播放| 十八岁以下禁止观看黄下载链接| 麻豆国产va免费精品高清在线| 亚洲乱色伦图片区小说| 99久久精品国产波多野结衣| 国产白嫩美女在线观看| 色综合久久88色综合天天| 曰本一道本久久88不卡| 在线天堂资源www| 激情内射亚洲一区二区三区爱妻|