在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Exosome complex component 10 (EXOSC10 PMSCL PMSCL2 RRP6)

  • 中文名稱:
  • 貨號:
    CSB-YP6146HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP6146HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP6146HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP6146HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP6146HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    EXOSX
  • Uniprot No.:
  • 別名:
    Exosome complex component 10; EC 3.1.13.-; Autoantigen PM/Scl 2; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; Polymyositis/scleroderma autoantigen 100 kDa; PM/Scl-100; Polymyositis/scleroderma autoantigen 2; EXOSC10 PMSCL PMSCL2 RRP6
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA.
  • 基因功能參考文獻:
    1. Rrp6: Integrated roles in nuclear RNA metabolism and transcription termination PMID: 26612606
    2. EXOSC10 can be modified by SUMOylation and identifies a physiological stress where this regulation is prevalent both in vitro and in vivo. PMID: 26857222
    3. Results show that DGCR8 forms an alternative complex with the RRP6-containing form of the exosome, acts as an adaptor to recruit the exosome to target structured RNAs, and the DGCR8/hRRP6 complex controls the stability of human telomerase RNA. PMID: 26687677
    4. Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR. PMID: 22980978
    5. Systemic sclerosis patients with anti-PM-Scl antibody are younger and significantly more often have limited cutaneous involvement, skeletal muscle disease, pulmonary fibrosis and calcinosis. PMID: 22261302
    6. Saccharomyces cerevisiae Rrp6, and determined the X-ray structure of a human construct containing the exoribonuclease and HRDC domains that retains catalytic activity PMID: 21705430
    7. cloning of a more complete cDNA for PM/Scl-75 encoded 84 additional amino acids at its N terminus and only this longer polypeptide is able to associate with the exosome complex. PMID: 12788944
    8. autoantibodies specific to this antigen also are found in systemic sclerosis PMID: 19103309
    9. Anti-PM/Scl antibodies are common in distinct SSc subsets and are associated with several clinical symptoms PMID: 19220911

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.
  • 數據庫鏈接:

    HGNC: 9138

    OMIM: 605960

    KEGG: hsa:5394

    STRING: 9606.ENSP00000366135

    UniGene: Hs.632368



主站蜘蛛池模板: 欧美成人看片一区二三区图文| 免费视频欧美无人区码| 少妇被粗大猛进进出出s小说| 麻花传媒mv在线观看| 国产乱人伦av在线a更新| 中日韩精品卡一卡二卡3卡| √最新版天堂资源网在线下载| 国产精品一区二区熟女不卡| 国产乱国产乱老熟300部视频| 99热这里只有精品最新地址获取| 亚洲va在线va天堂va欧美va| 欧美人与动牲交免费观看| 国产精品亚洲а∨天堂2021| 中文人妻av久久人妻18| 天天躁日日躁狠狠躁性色av| 欧美天天综合色影久久精品| 国产成人精品a视频| 国产成人精品久久一区二区三区| 中国xxx农村性视频| 欧美精品videossex少妇| 欧美乱妇高清无乱码在线观看| 一本丁香综合久久久久不卡网站| 精品偷拍被偷拍在线观看| 无码人妻一区、二区、三区免费视频 | 久久这里只有是精品23| 中文乱码免费一区二区三区| 波多野结衣久久一区二区| 2020精品国产视| 国产精品无码午夜免费影院| 国产9色在线 | 日韩| 西西人体大胆午夜啪啪| 亚洲性色成人av| 亚洲日韩一区二区| 久久国产劲爆∧v内射-百度| 日韩欧国产精品一区综合无码| 国产偷国产偷亚州清高app| 国产精品免费久久久久影院| 国产精品白丝av在线观看播放| 国产剧情无码播放在线观看| 亚洲 欧美 日韩 综合aⅴ| 精品国产久九九|