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  4. EXOSC10 Antibody, FITC conjugated

EXOSC10 Antibody, FITC conjugated

  • 中文名稱：
    EXOSC10兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA007889LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) EXOSC10 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Autoantigen PM/Scl 2 antibody; Exosc10 antibody; Exosome component 10 antibody; EXOSX_HUMAN antibody; P100 polymyositis scleroderma overlap syndrome associated autoantigen antibody; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen antibody; p2 antibody; p3 antibody; p4 antibody; PM Scl antibody; PM/Scl 100 antibody; PM/Scl-100 antibody; PMSCL antibody; PMSCL2 antibody; Polymyositis/scleroderma autoantigen 100 kDa antibody; Polymyositis/scleroderma autoantigen 2 100 kDa antibody; Polymyositis/scleroderma autoantigen 2 antibody; RRP6 antibody; Rrp6p antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Exosome component 10 protein (587-762AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA.
  • 基因功能參考文獻：
    1. Rrp6: Integrated roles in nuclear RNA metabolism and transcription termination PMID: 26612606
    2. EXOSC10 can be modified by SUMOylation and identifies a physiological stress where this regulation is prevalent both in vitro and in vivo. PMID: 26857222
    3. Results show that DGCR8 forms an alternative complex with the RRP6-containing form of the exosome, acts as an adaptor to recruit the exosome to target structured RNAs, and the DGCR8/hRRP6 complex controls the stability of human telomerase RNA. PMID: 26687677
    4. Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR. PMID: 22980978
    5. Systemic sclerosis patients with anti-PM-Scl antibody are younger and significantly more often have limited cutaneous involvement, skeletal muscle disease, pulmonary fibrosis and calcinosis. PMID: 22261302
    6. Saccharomyces cerevisiae Rrp6, and determined the X-ray structure of a human construct containing the exoribonuclease and HRDC domains that retains catalytic activity PMID: 21705430
    7. cloning of a more complete cDNA for PM/Scl-75 encoded 84 additional amino acids at its N terminus and only this longer polypeptide is able to associate with the exosome complex. PMID: 12788944
    8. autoantibodies specific to this antigen also are found in systemic sclerosis PMID: 19103309
    9. Anti-PM/Scl antibodies are common in distinct SSc subsets and are associated with several clinical symptoms PMID: 19220911

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  • 亞細胞定位：
    Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.
  • 數據庫鏈接：

    HGNC: 9138

    OMIM: 605960

    KEGG: hsa:5394

    STRING: 9606.ENSP00000366135

    UniGene: Hs.632368



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