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  4. Recombinant Human Exonuclease 3'-5' domain-containing protein 2 (EXD2), partial

Recombinant Human Exonuclease 3'-5' domain-containing protein 2 (EXD2), partial

  • 中文名稱：
    人EXD2重組蛋白
  • 貨號：
    CSB-YP873662HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人EXD2重組蛋白
  • 貨號：
    CSB-EP873662HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人EXD2重組蛋白
  • 貨號：
    CSB-EP873662HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人EXD2重組蛋白
  • 貨號：
    CSB-BP873662HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人EXD2重組蛋白
  • 貨號：
    CSB-MP873662HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    EXD2
  • Uniprot No.：
  • 別名：
    4930539P14Rik; C14orf114; C85658; DKFZp781A0133; DKFZp781L15100; Exd2; EXD2_HUMAN; EXDL2; Exonuclease 3''-5'' domain-containing protein 2; Exonuclease 3''-5'' domain-like-containing protein 2; exonuclease 3'-5' domain-like 2; FLJ10738; RGD1311087
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation.
  • 基因功能參考文獻：
    1. establish that EXD2 stimulates both short- and long-range DSB resection PMID: 26807646
  • 亞細胞定位：
    Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion matrix. Nucleus. Chromosome.
  • 蛋白家族：
    EXD2 family
  • 數據庫鏈接：

    HGNC: 20217

    OMIM: 616940

    KEGG: hsa:55218

    STRING: 9606.ENSP00000313140

    UniGene: Hs.533878



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