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EXD2 Antibody, HRP conjugated

  • 中文名稱:
    EXD2兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào):
    CSB-PA873662LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) EXD2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EXD2
  • 別名:
    4930539P14Rik antibody; C14orf114 antibody; C85658 antibody; DKFZp781A0133 antibody; DKFZp781L15100 antibody; Exd2 antibody; EXD2_HUMAN antibody; EXDL2 antibody; Exonuclease 3''-5'' domain-containing protein 2 antibody; Exonuclease 3''-5'' domain-like-containing protein 2 antibody; exonuclease 3'-5' domain-like 2 antibody; FLJ10738 antibody; RGD1311087 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Exonuclease 3\'-5\' domain-containing protein 2 protein (137-245AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks. Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation.
  • 基因功能參考文獻(xiàn):
    1. establish that EXD2 stimulates both short- and long-range DSB resection PMID: 26807646
  • 亞細(xì)胞定位:
    Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion matrix. Nucleus. Chromosome.
  • 蛋白家族:
    EXD2 family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 20217

    OMIM: 616940

    KEGG: hsa:55218

    STRING: 9606.ENSP00000313140

    UniGene: Hs.533878



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