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  4. Recombinant Human Exocyst complex component 2 (EXOC2), partial

Recombinant Human Exocyst complex component 2 (EXOC2), partial

  • 中文名稱：
    人EXOC2重組蛋白
  • 貨號：
    CSB-YP007878HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人EXOC2重組蛋白
  • 貨號：
    CSB-EP007878HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人EXOC2重組蛋白
  • 貨號：
    CSB-EP007878HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人EXOC2重組蛋白
  • 貨號：
    CSB-BP007878HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人EXOC2重組蛋白
  • 貨號：
    CSB-MP007878HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    EXOC2; EXOC2_HUMAN; Exocyst complex component 2; Exocyst complex component Sec5; FLJ11026 ; SEC5; SEC5 like 1; SEC5L1; Sec5p
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
  • 基因功能參考文獻：
    1. data suggest that the induction of SGK1 through treatment with dexamethasone alters MT dynamics to increase Sec5-GEF-H1 interactions, which promote GEF-H1 targeting to adhesion sites. PMID: 26359301
    2. Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion. PMID: 23844030
    3. We identified interactions between RalA and its effectors sec5 and exo84 in the Exocyst complex as directly necessary for migration and invasion of prostate cancer tumor cells. PMID: 22761837
    4. Data show that Mc1R, HERC2, IRF4, TYR and EXOC2 are ranked highest in hair color prediction analysis. PMID: 21197618
    5. shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-driven tumorigenic growth of human cells. PMID: 20145037
    6. SEC5 has been identified as a binding partner of deafness locus putative guanine nucleotide exchange factor. PMID: 12459492
    7. evidence that mammalian exocyst components are present as distinct subcomplexes on vesicles and the plasma membrane and that Ral GTPases regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84 PMID: 14525976
    8. These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling. PMID: 17018283
    9. Localization of Exocyst and, by extension, targeting of Exocyst-dependent cargo, is dependent on Ral GTPases, which control association between Sec5 and paxillin. PMID: 18697830
    10. Functional study of the Drosophila homolog. PMID: 12575951

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  • 亞細胞定位：
    Midbody, Midbody ring.
  • 蛋白家族：
    SEC5 family
  • 組織特異性：
    Widely expressed with highest levels in brain and placenta.
  • 數據庫鏈接：

    HGNC: 24968

    OMIM: 615329

    KEGG: hsa:55770

    STRING: 9606.ENSP00000230449

    UniGene: Hs.484412



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