在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Eukaryotic translation initiation factor 5 (EIF5)

In Stock
  • 中文名稱:
    人EIF5重組蛋白
  • 貨號(hào):
    CSB-EP007572HU
  • 規(guī)格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    EIF5
  • Uniprot No.:
  • 別名:
    2810011H21Rik; D12Ertd549e; EIF 5; EIF 5A; eIF-5; Eif5; Eukaryotic initiation factor 5; Eukaryotic translation initiation factor 5; IF5_HUMAN; MGC36374; MGC36509
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Full Length
  • 來(lái)源:
    E.coli
  • 分子量:
    65.2kDa
  • 表達(dá)區(qū)域:
    1-431aa
  • 氨基酸序列
    MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDSGTGKKEKEKKNRKGKDKENGSVSSSETPPPPPPPNEINPPPHTMEEEEDDDWGEDTTEEAQRRRMDEISDHAKVLTLSDDLERTIEERVNILFDFVKKKKEEGVIDSSDKEIVAEAERLDVKAMGPLVLTEVLFNEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKAASVPKVETVKSDNKDDDIDIDAI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-SUMO-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).
  • 基因功能參考文獻(xiàn):
    1. The down-regulation of the GCN4 expression (Gcn(-) phenotype) in the eIF5(G31R) mutant was not because of leaky scanning defects; rather was due to the utilization of upUUG initiation codons at the 5' regulatory region present between uORF1 and the main GCN4 ORF. PMID: 28385532
    2. overexpression of eIF5 and 5MP induces translation of ATF4 PMID: 27325740
    3. it is eIF5-induced GTP hydrolysis and Pi release that irreversibly trap the 48S complex, and this complex is further stabilized by eIF5B and 60S joining. PMID: 26717981
    4. The N-terminal tail of eIF1A mediates the interaction with eIF5 and eIF1. PMID: 24319994
    5. This study provides mechanistic insight into the role of eIF5-carboxyl terminal domain's dynamic interplay with eIF1 and eIF2beta. PMID: 22813744
    6. miR-5787 represses cell growth, in part, by targeting eIF5. PMID: 22062548
    7. 3-dimensional solution structure of N-terminal domain of human eIF5, has 2 subdomains, both reminiscent of nucleic-acid-binding modules. N-terminal subdomain contains "arginine finger" motif essential for GAP function. PMID: 16584190
    8. The carboxy-terminal domain (CTD)of eIF5 is exclusively composed out of alpha-helices and is homologous to the carboxy-terminal domain of eIF2B-epsilon (eIF2Bepsilon-CTD). The binding sites of eIF2-beta, eIF3 and eIF1 were mapped onto the structure. PMID: 16781736

    顯示更多

    收起更多

  • 蛋白家族:
    EIF-2-beta/eIF-5 family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 3299

    OMIM: 601710

    KEGG: hsa:1983

    STRING: 9606.ENSP00000216554

    UniGene: Hs.433702



主站蜘蛛池模板: 丰满少妇被猛烈进入无码| 任我爽橹在线精品视频| 99精品国产一区二区三区不卡 | 亚洲无线码一区二区三区| 大伊香蕉精品视频在线| 中国女人内谢69xxxx视频| 日本特黄特黄刺激大片| 久久午夜色播影院| 天堂无码人妻精品av一区| 天干天干天啪啪夜爽爽av| 韩国午夜福利片在线观看| 亚洲国产成人精品无码区蜜柚| 少妇被躁爽到高潮无码文| 中文字幕无线码一区2020青青| 亚洲欧洲日本无在线码| 天堂va欧美ⅴa亚洲va| 精品久久久久久中文字幕人妻最新| 亚洲a∨无码一区二区| 色综合欧美亚洲国产| 骚动漫十八禁在线观看| 熟妇人妻系列aⅴ无码专区友真希| 久久久久久久女国产乱让韩| 亚洲中文字幕不卡无码| 欧美亚洲日本高清不卡| 国产成人无码aⅴ片在线观看| 精品一区二区三人妻视频| 国产精品久久久久久久伊一| 中文字幕日韩精品有码视频 | 欧美精品videosex性欧美| 一二三四免费观看在线视频中文版 | 乱中年女人伦| 国产乱码日产精品bd| 国产成人理论无码电影网| 亚洲精品一线二线三线无人区| 激情毛片无码专区| 不卡av中文字幕手机看| 亚洲欧美成aⅴ人在线观看| 波多野结衣 黑人| 亚洲欧洲免费三级网站| 国产人妻xxxx精品hd| 国产成人精品一区二区三区|