在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Erlin-2 (ERLIN2), partial

Recombinant Human Erlin-2 (ERLIN2), partial

  • 中文名稱：
    人ERLIN2重組蛋白
  • 貨號：
    CSB-YP007791HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ERLIN2重組蛋白
  • 貨號：
    CSB-EP007791HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ERLIN2重組蛋白
  • 貨號：
    CSB-EP007791HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ERLIN2重組蛋白
  • 貨號：
    CSB-BP007791HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ERLIN2重組蛋白
  • 貨號：
    CSB-MP007791HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ERLIN2
  • Uniprot No.：
  • 別名：
    ERLIN2; C8orf2; SPFH2; UNQ2441/PRO5003/PRO9924; Erlin-2; Endoplasmic reticulum lipid raft-associated protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; SPFH domain-containing protein 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex.
  • 基因功能參考文獻：
    1. Novel Mutations in Endoplasmic Reticulum Lipid Raft-associated Protein 2 Gene Cause Pure Hereditary Spastic Paraplegia Type 18 PMID: 27824013
    2. Erlin-2 and the related erlin-1 were found to negatively regulate cholesterol and fatty acid biosynthesis in cultured cell models when the proteins were depleted by RNAi. The proteins also selectively bound cholesterol. PMID: 24217618
    3. ERLIN2 was found to be responsible for causing hereditary spastic paraplegia in a Saudi family. PMID: 23085305
    4. ERLIN2 may confer a selective growth advantage for breast cancer cells by facilitating a cytoprotective response to various cellular stresses associated with oncogenesis. PMID: 22681620
    5. ERLIN2 loss on cell growth may advance understanding of the mechanism behind motor neuron degeneration in primary lateral sclerosis PMID: 23109145
    6. a novel brain gamma-secretase associated protein , erlin-2, that resides in detergent resistant membranes and affects amyloid beta-peptide production. PMID: 22771797
    7. a novel role for ERLIN2 in supporting cancer cell growth by promoting the activation of the key lipogenic regulator SREBP1c and the production of cytosolic lipid droplets. PMID: 22690709
    8. study describes an extended consanguineous Saudi family in which hereditary spastic paraplegia is linked to SPG18, an autosomal recessive locus, and show it is associated with a nullimorphic deletion of ERLIN2 PMID: 21796390
    9. The gene encodes endoplasmic reticulum (ER) lipid raft-associated protein 2 that mediates the ER-associated degradation of activated inositol 1,4,5-trisphosphate receptors and other substrates. PMID: 21330303
    10. SPFH2 as a key endoplasmic reticulum associated degradation pathway component and suggest that it may act as a substrate recognition factor. PMID: 17502376

    顯示更多

    收起更多

  • 相關疾病：
    Spastic paraplegia 18, autosomal recessive (SPG18)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
  • 蛋白家族：
    Band 7/mec-2 family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 1356

    OMIM: 611225

    KEGG: hsa:11160

    STRING: 9606.ENSP00000276461

    UniGene: Hs.705490



主站蜘蛛池模板： 精品人妻伦一二三区久久aaa片| 国产精品久久久久久成人影院| 人妻熟女一区二区aⅴ图片| 日韩欧美亚洲中文乱码| 国产做爰xxxⅹ久久久精华液| 国产精品亚洲αv天堂无码| 久久99精品国产麻豆蜜芽| 国产午夜精品一区二区三区漫画| 国产高清色高清在线观看| 亚洲日韩aⅴ在线视频| 亚洲 自拍 另类小说综合图区| 成人片黄网站a毛片免费观看| 天堂最新版在线www官网中文地址| 国产精品国产三级国产av主播 | 草草影院精品一区二区三区| 精品国偷自产在线视频99| 精品成人av一区二区三区| 国产精品乱码一区二区三区 | 日本乱子人伦在线视频| 狠狠色丁香婷婷综合尤物| 欧美黑人巨大videos极品| 激情综合一区二区三区| 色一情一乱一伦一视频免费看| 国产成人亚洲高清一区| 丝袜高潮流白浆潮喷在线播放 | 久久综合久中文字幕青草| 性视频播放免费视频| 男女裸体下面进入的免费视频| 午夜肉伦伦影院| 久久久久人妻一区二区三区| 玩弄少妇高潮ⅹxxxyw| 女人裸露免费视频无遮挡网站| 日产精品卡二卡三卡四卡区满十八| 欧美激情a∨在线视频播放| √天堂资源地址在线官网| 国产午精品午夜福利757视频播放| 香蕉久久人人爽人人爽人人片av| 国产精品无码无需播放器| yyyy11111少妇影院| 少妇高潮喷水惨叫久久久久电影| 狠狠色噜噜狠狠狠8888米奇|