在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ERLIN2 Antibody

ERLIN2 Antibody

  • 中文名稱：
    ERLIN2兔多克隆抗體
  • 貨號：
    CSB-PA007791ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA007791ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA007791ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ERLIN2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ERLIN2
  • 別名：
    ERLIN2; C8orf2; SPFH2; UNQ2441/PRO5003/PRO9924; Erlin-2; Endoplasmic reticulum lipid raft-associated protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; SPFH domain-containing protein 2
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Erlin-2 protein (212-339AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex.
  • 基因功能參考文獻：
    1. Novel Mutations in Endoplasmic Reticulum Lipid Raft-associated Protein 2 Gene Cause Pure Hereditary Spastic Paraplegia Type 18 PMID: 27824013
    2. Erlin-2 and the related erlin-1 were found to negatively regulate cholesterol and fatty acid biosynthesis in cultured cell models when the proteins were depleted by RNAi. The proteins also selectively bound cholesterol. PMID: 24217618
    3. ERLIN2 was found to be responsible for causing hereditary spastic paraplegia in a Saudi family. PMID: 23085305
    4. ERLIN2 may confer a selective growth advantage for breast cancer cells by facilitating a cytoprotective response to various cellular stresses associated with oncogenesis. PMID: 22681620
    5. ERLIN2 loss on cell growth may advance understanding of the mechanism behind motor neuron degeneration in primary lateral sclerosis PMID: 23109145
    6. a novel brain gamma-secretase associated protein , erlin-2, that resides in detergent resistant membranes and affects amyloid beta-peptide production. PMID: 22771797
    7. a novel role for ERLIN2 in supporting cancer cell growth by promoting the activation of the key lipogenic regulator SREBP1c and the production of cytosolic lipid droplets. PMID: 22690709
    8. study describes an extended consanguineous Saudi family in which hereditary spastic paraplegia is linked to SPG18, an autosomal recessive locus, and show it is associated with a nullimorphic deletion of ERLIN2 PMID: 21796390
    9. The gene encodes endoplasmic reticulum (ER) lipid raft-associated protein 2 that mediates the ER-associated degradation of activated inositol 1,4,5-trisphosphate receptors and other substrates. PMID: 21330303
    10. SPFH2 as a key endoplasmic reticulum associated degradation pathway component and suggest that it may act as a substrate recognition factor. PMID: 17502376

    顯示更多

    收起更多

  • 相關疾病：
    Spastic paraplegia 18, autosomal recessive (SPG18)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
  • 蛋白家族：
    Band 7/mec-2 family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 1356

    OMIM: 611225

    KEGG: hsa:11160

    STRING: 9606.ENSP00000276461

    UniGene: Hs.705490



主站蜘蛛池模板： 精品无人区麻豆乱码1区2区| 亚洲成av人综合在线观看| 99精品国产99久久久久久97| 国产成人手机高清在线观看网站| 欧美午夜片欧美片在线观看| 久久精品九九亚洲精品天堂| 欧美黑人乱大交| 亚洲精品久久7777777| 无码av中文字幕免费放| 最新国产久免费视频在线观看| 欧美白丰满老太aaa片| 狠狠色综合tv久久久久久| 国产肉体xxxx裸体137大胆| 又黄又硬又湿又刺激视频免费| 色综合亚洲一区二区小说性色aⅴ| 色欲香天天天综合网站| 国产激情无码一区二区三区| 无码成人片在线播放| 国产剧情无码播放在线观看| 天天躁日日躁狠狠躁一区| 国产乡下三级全黄三级bd| 成人a大片在线观看| 噜噜高清欧美内射短视频| 免费看成人aa片无码视频吃奶| 一本大道久久东京热无码av| 日韩加勒比一本无码精品| 伊人久久大香线蕉成人| 大陆国语对白国产av片| 国产熟妇勾子乱视频| 翘臀后进少妇大白嫩屁股| 亚洲精品少妇一区二区| 久久亚洲国产成人精品无码区| 亚洲欧美中文字幕5发布| 国产精品69人妻无码久久| 国产精品无码午夜免费影院| 日出水了特别黄的视频| 骚虎视频在线观看| 无码少妇高潮浪潮av久久| 极品少妇被猛的白浆直喷白浆| 国产欧美熟妇另类久久久| 国产在线看片免费视频|