在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Eomesodermin homolog (EOMES)

Recombinant Human Eomesodermin homolog (EOMES)

  • 中文名稱：
    人EOMES重組蛋白
  • 貨號：
    CSB-YP007701HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人EOMES重組蛋白
  • 貨號：
    CSB-EP007701HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人EOMES重組蛋白
  • 貨號：
    CSB-EP007701HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人EOMES重組蛋白
  • 貨號：
    CSB-BP007701HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人EOMES重組蛋白
  • 貨號：
    CSB-MP007701HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    EOMES
  • Uniprot No.：
  • 別名：
    eomes; EOMES_HUMAN; Eomesodermin; Eomesodermin homolog; t box brain 2; T-box brain protein 2; T-brain-2; Tbr 2; TBR-2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-686
  • 氨基酸序列
    MQLGEQLLVS SVNLPGAHFY PLESARGGSG GSAGHLPSAA PSPQKLDLDK ASKKFSGSLS CEAVSGEPAA ASAGAPAAML SDTDAGDAFA SAAAVAKPGP PDGRKGSPCG EEELPSAAAA AAAAAAAAAA TARYSMDSLS SERYYLQSPG PQGSELAAPC SLFPYQAAAG APHGPVYPAP NGARYPYGSM LPPGGFPAAV CPPGRAQFGP GAGAGSGAGG SSGGGGGPGT YQYSQGAPLY GPYPGAAAAG SCGGLGGLGV PGSGFRAHVY LCNRPLWLKF HRHQTEMIIT KQGRRMFPFL SFNINGLNPT AHYNVFVEVV LADPNHWRFQ GGKWVTCGKA DNNMQGNKMY VHPESPNTGS HWMRQEISFG KLKLTNNKGA NNNNTQMIVL QSLHKYQPRL HIVEVTEDGV EDLNEPSKTQ TFTFSETQFI AVTAYQNTDI TQLKIDHNPF AKGFRDNYDS SHQIVPGGRY GVQSFFPEPF VNTLPQARYY NGERTVPQTN GLLSPQQSEE VANPPQRWLV TPVQQPGTNK LDISSYESEY TSSTLLPYGI KSLPLQTSHA LGYYPDPTFP AMAGWGGRGS YQRKMAAGLP WTSRTSPTVF SEDQLSKEKV KEEIGSSWIE TPPSIKSLDS NDSGVYTSAC KRRRLSPSNS SNENSPSIKC EDINAEEYSK DTSKGMGGYY AFYTTP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.
  • 基因功能參考文獻：
    1. This study enhances the knowledge that the variant of EOMES is associated with increasing risk in Chinese RRMS patients and provides a potential therapeutic target in RRMS. PMID: 29521285
    2. our exploratory study suggests that EOMES, BCL6 and GZMB gene expression are aberrant within the PB T cell transcriptome of HT patients. The association of this transcription signature with the heterogeneity of HT and disease control is suggested. PMID: 29319368
    3. EOMES specifically activates a cardiogenic program in human embryonic stem cells. PMID: 29382828
    4. Studies suggest there are two nonoverlapping NK cell populations that are potentially liver resident in humans: CD49a+ NK cells and Eomes hi. PMID: 28318877
    5. Reciprocal regulation of BMF and BIRC5 is linked to Eomes overexpression in colorectal cancer. PMID: 27539959
    6. Eomes(hi) NK cells can be recruited from the circulation during adult life and that circulating Eomes(lo) NK cells are able to upregulate Eomes and molecules mediating liver retention under cytokine conditions similar to those in the liver. PMID: 27798170
    7. EOMES expression was low in multiple sclerosis (MS), and stable over time. The low EOMES/TBX21 phenotype in MS reflects cd56+ cell dysregulation. PMID: 26762769
    8. we identified a higher Eomes mRNA expression as an independent good prognostic factor for OS and PFS in mRCC patients treated with sorafenib. PMID: 26753694
    9. Eomes(+) CD4(+) T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis. PMID: 26436530
    10. the level of T-bet and Eomesodermin, two T-box transcription factors regulating lymphocyte effector functions, is strongly reduced in NK cells from allogeneic hematopoietic stem cell transplantation recipients compared with healthy control subjects. PMID: 26438526
    11. This study showed that EOMES (rs2724509; flanking) associated with Alzheimer disease. PMID: 25649652
    12. This study supports the concept that poor human viral-specific CD8(+) T cell functionality is due to an inverse expression balance between T-bet and Eomes PMID: 25032686
    13. Report a global loss of 5hmC identified three new genes (ECM1, ATF5, and EOMES) with potential anti-cancer functions that may promote the understanding of the molecular mechanisms of hepatocellular carcinoma development and progression. PMID: 25517360
    14. HHEX promotes hepatic specification by repressing EOMES expression. PMID: 24651531
    15. CD127 is downregulated at a transcriptional level in memory CD8 T cells in association with upregulation of Eomes expression in HIV infected patients. PMID: 23965471
    16. The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. PMID: 24495857
    17. these results provide the evidence that transcription factors CDX2 and EOMES may play critical roles in human induced trophoblast progenitor cell generation. PMID: 23313847
    18. a novel pathway by which TIP60 and ThPOK synergistically suppresses Eomes function and IFNgamma production, which could contribute to the regulation of inflammation. PMID: 23609452
    19. T-bet and Eomes are likely regulated at the level of subcellular localization, potentially via different mechanisms. PMID: 23455505
    20. Describes cloning of the human TBR2 gene and compares the human and mouse protein sequences. PMID: 10407135
    21. Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors. PMID: 22490682
    22. transcription factors control the expression of EOMESODERMIN (EOMES), which marks the onset of endoderm specification and EOMES interacts with SMAD2/3 to initiate the transcriptional network governing endoderm formation PMID: 21245162
    23. ymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin. PMID: 21076068
    24. CD300a(+) human Th1 cells tend to be polyfunctional and after stimulation up-regulate Eomes. PMID: 20498708
    25. T-bet and Eomes are important transcription factors for the regulation of IFN-gamma production in CD4(+) and CD8(+) T cells. PMID: 20056084
    26. A key transcription factor that links the long-term renewal of memory CD8+ T cells to their characteristic effector potency. PMID: 16273099
    27. Breakpoint on chromosome 3 silences the eomesodermin transcript (EOMES) leading to malformative microcephaly syndromes. PMID: 17353897
    28. Accessible chromatin-associated (histone 3 lysine 9) acetylation state serves as a cornerstone for differentially high expression of effector gene eomesodermin and its targets perforin 1 and granzyme B in memory CD8 T cells. PMID: 18523274
    29. Conditional ablation of Tbr2 transgene in the developing murine forebrain results in loss of intermediate (basal) progenitor cells and their differentiated progeny in the mutant cortex. PMID: 18940588
    30. regulates effector CD8+ T cell differentiation into long-term memory cells PMID: 19269192

    顯示更多

    收起更多

  • 相關疾病：
    A translocation t(3;10)(p24;q23) located 215 kb 3' to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum.
  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in CD8+ T-cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3372

    OMIM: 604615

    KEGG: hsa:8320

    STRING: 9606.ENSP00000295743

    UniGene: Hs.591663



主站蜘蛛池模板： 一色屋精品视频在线观看免费| 国产98在线 | 日韩| 人妻少妇久久中文字幕456| 不卡高清av手机在线观看| 图片区小说区av区| 热re99久久精品国99热| 性荡视频播放在线视频| 影音先锋无码a∨男人资源站| 免费国产黄线在线观看| 玩弄中年熟妇正在播放| 狠狠爱亚洲五月婷婷av| 免费大片av手机看片不卡| 天天躁夜夜躁狠狠是什么心态| 久久99国产精品久久99果冻传媒 | 国色天香天天影院综合网| 久久久99精品成人片| 亚洲高清偷拍一区二区三区| 豆国产97在线 | 亚洲| 色欲av巨乳无码一区二区| 曰批全过程免费视频观看软件潮喷 | 国产熟妇另类久久久久久| 久久国产av影片| 午夜久久久久久禁播电影| 曰本无码不卡高清av一二| 午夜亚洲影院在线观看| av东京热无码专区| 插我舔内射18免费视频| 日本少妇xxx做受| 亚洲午夜久久久精品影院| 成 人 色 网 站免费观看| 久久综合九色综合欧美就去吻| 国产精品无码久久四虎| 欧美三根一起进三p| 狠狠色噜噜狠狠色综合久| 午夜福利不卡片在线机免费视频| 少妇人妻偷人精品视频| 久久久国产精品亚洲一区| 国产成人亚洲综合图区| 内射人妻少妇无码一本一道 | 免费国产成人午夜福利电影| 国产免费一区二区三区在线观看|