在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EOMES Antibody

  • 中文名稱:
    EOMES兔多克隆抗體
  • 貨號(hào):
    CSB-PA002351
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HepG2 cells using EOMES Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    EOMES
  • 別名:
    eomes antibody; EOMES_HUMAN antibody; Eomesodermin antibody; Eomesodermin homolog antibody; t box brain 2 antibody; T-box brain protein 2 antibody; T-brain-2 antibody; Tbr 2 antibody; TBR-2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human EOMES.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.
  • 基因功能參考文獻(xiàn):
    1. This study enhances the knowledge that the variant of EOMES is associated with increasing risk in Chinese RRMS patients and provides a potential therapeutic target in RRMS. PMID: 29521285
    2. our exploratory study suggests that EOMES, BCL6 and GZMB gene expression are aberrant within the PB T cell transcriptome of HT patients. The association of this transcription signature with the heterogeneity of HT and disease control is suggested. PMID: 29319368
    3. EOMES specifically activates a cardiogenic program in human embryonic stem cells. PMID: 29382828
    4. Studies suggest there are two nonoverlapping NK cell populations that are potentially liver resident in humans: CD49a+ NK cells and Eomes hi. PMID: 28318877
    5. Reciprocal regulation of BMF and BIRC5 is linked to Eomes overexpression in colorectal cancer. PMID: 27539959
    6. Eomes(hi) NK cells can be recruited from the circulation during adult life and that circulating Eomes(lo) NK cells are able to upregulate Eomes and molecules mediating liver retention under cytokine conditions similar to those in the liver. PMID: 27798170
    7. EOMES expression was low in multiple sclerosis (MS), and stable over time. The low EOMES/TBX21 phenotype in MS reflects cd56+ cell dysregulation. PMID: 26762769
    8. we identified a higher Eomes mRNA expression as an independent good prognostic factor for OS and PFS in mRCC patients treated with sorafenib. PMID: 26753694
    9. Eomes(+) CD4(+) T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis. PMID: 26436530
    10. the level of T-bet and Eomesodermin, two T-box transcription factors regulating lymphocyte effector functions, is strongly reduced in NK cells from allogeneic hematopoietic stem cell transplantation recipients compared with healthy control subjects. PMID: 26438526
    11. This study showed that EOMES (rs2724509; flanking) associated with Alzheimer disease. PMID: 25649652
    12. This study supports the concept that poor human viral-specific CD8(+) T cell functionality is due to an inverse expression balance between T-bet and Eomes PMID: 25032686
    13. Report a global loss of 5hmC identified three new genes (ECM1, ATF5, and EOMES) with potential anti-cancer functions that may promote the understanding of the molecular mechanisms of hepatocellular carcinoma development and progression. PMID: 25517360
    14. HHEX promotes hepatic specification by repressing EOMES expression. PMID: 24651531
    15. CD127 is downregulated at a transcriptional level in memory CD8 T cells in association with upregulation of Eomes expression in HIV infected patients. PMID: 23965471
    16. The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. PMID: 24495857
    17. these results provide the evidence that transcription factors CDX2 and EOMES may play critical roles in human induced trophoblast progenitor cell generation. PMID: 23313847
    18. a novel pathway by which TIP60 and ThPOK synergistically suppresses Eomes function and IFNgamma production, which could contribute to the regulation of inflammation. PMID: 23609452
    19. T-bet and Eomes are likely regulated at the level of subcellular localization, potentially via different mechanisms. PMID: 23455505
    20. Describes cloning of the human TBR2 gene and compares the human and mouse protein sequences. PMID: 10407135
    21. Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors. PMID: 22490682
    22. transcription factors control the expression of EOMESODERMIN (EOMES), which marks the onset of endoderm specification and EOMES interacts with SMAD2/3 to initiate the transcriptional network governing endoderm formation PMID: 21245162
    23. ymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin. PMID: 21076068
    24. CD300a(+) human Th1 cells tend to be polyfunctional and after stimulation up-regulate Eomes. PMID: 20498708
    25. T-bet and Eomes are important transcription factors for the regulation of IFN-gamma production in CD4(+) and CD8(+) T cells. PMID: 20056084
    26. A key transcription factor that links the long-term renewal of memory CD8+ T cells to their characteristic effector potency. PMID: 16273099
    27. Breakpoint on chromosome 3 silences the eomesodermin transcript (EOMES) leading to malformative microcephaly syndromes. PMID: 17353897
    28. Accessible chromatin-associated (histone 3 lysine 9) acetylation state serves as a cornerstone for differentially high expression of effector gene eomesodermin and its targets perforin 1 and granzyme B in memory CD8 T cells. PMID: 18523274
    29. Conditional ablation of Tbr2 transgene in the developing murine forebrain results in loss of intermediate (basal) progenitor cells and their differentiated progeny in the mutant cortex. PMID: 18940588
    30. regulates effector CD8+ T cell differentiation into long-term memory cells PMID: 19269192

    顯示更多

    收起更多

  • 相關(guān)疾病:
    A translocation t(3;10)(p24;q23) located 215 kb 3' to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum.
  • 亞細(xì)胞定位:
    Nucleus.
  • 組織特異性:
    Expressed in CD8+ T-cells.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 3372

    OMIM: 604615

    KEGG: hsa:8320

    STRING: 9606.ENSP00000295743

    UniGene: Hs.591663



主站蜘蛛池模板: 日本丰满熟妇videossex| 各种少妇正面bbw撒尿| 色综合久久蜜芽国产精品| 国产精品久久久久蜜臀| 日韩av一国产av一中文字慕| 国产两女互慰高潮视频在线观看| 亚洲精品久久久久玩吗| 国产精品爱久久久久久久| 免费女人裸体视频无遮挡免费网站 | 亚洲a无码综合a国产av中文| 久久一日本道色综合久久| 久99久热只有精品国产女同| 被窝的午夜无码福利专区| 亚洲国产欧美在线人成| 日本精品少妇一区二区三区| 白丝美女被狂躁免费视频网站| 亚洲中文字幕无码卡通动漫野外 | 国产精品无码v在线观看| 亚洲欧美精品伊人久久| 女性自慰网站免费看ww| 欧美巨大xxxx做受中文字幕| 色噜噜一区二区三区| 野狼第一精品社区| 亚洲中文字幕久久精品蜜桃| 亚洲精品久久久久一区二区| 国产国语老龄妇女a片| 欧美极品video粗暴| 国产爽视频在线观看视频| 欧美黑人乱大交| 大战熟女丰满人妻av| 中文字幕中文有码在线| 无码毛片一区二区本码视频| 丰满爆乳一区二区三区| 欧美黑人又粗又硬xxxxx喷水| 成年站免费网站看v片在线| 成年男女免费视频网站| 国产精品不卡无码av在线播放| 国产精品久久久久9999不卡| 麻豆md0077饥渴少妇| 欧美成人精品手机在线| 最近中文字幕免费大全在线|