在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Elongation factor Tu, mitochondrial (TUFM)

In Stock
  • 中文名稱:
    人TUFM重組蛋白
  • 貨號(hào):
    CSB-EP025342HUa0
  • 規(guī)格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    TUFM
  • Uniprot No.:
  • 別名:
    COXPD4; EF Tu; EF TuMT; EF-Tu; EF-TuMT; EFTu; EFTU_HUMAN; EFTuMT; Elongation factor Tu; Elongation factor Tu mitochondrial; mitochondrial; P43; Tu translation elongation factor; mitochondrial; Tufm
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    49.0 kDa
  • 表達(dá)區(qū)域:
    47-455aa
  • 氨基酸序列
    AVEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAANDGPMPQTREHLLLARQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEETPVIVGSALCALEGRDPELGLKSVQKLLDAVDTYIPVPARDLEKPFLLPVEAVYSVPGRGTVVTGTLERGILKKGDECELLGHSKNIRTVVTGIEMFHKSLERAEAGDNLGALVRGLKREDLRRGLVMVKPGSIKPHQKVEAQVYILSKEEGGRHKPFVSHFMPVMFSLTWDMACRIILPPEKELAMPGEDLKFNLILRQPMILEKGQRFTLRDGNRTIGTGLVTNTLAMTEEEKNIKWG
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.
  • 基因功能參考文獻(xiàn):
    1. Novel mutation in mitochondrial Elongation Factor EF-Tu associated to dysplastic leukoencephalopathy and defective mitochondrial DNA translation. PMID: 28132884
    2. study revealed a novel role for TUFM as a host restriction factor that exerts an inhibitory effect on avian-signature PB2627E influenza virus propagation in human cells; found that increased TUFM-dependent autophagy correlates with the inhibitory effect on avian-signature influenza virus replication and may serve as a key intrinsic mechanism to restrict avian influenza virus infection in humans PMID: 28611246
    3. High expression of TUFM is associated with colorectal cancer. PMID: 28449687
    4. we identify a novel signaling hub centering on the NLRX1 TUFM protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM result in compromised autophagy when treated with EGFR inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR inhibitors. PMID: 26876213
    5. TUFM is a novel regulator of epithelial-mesenchymal transition (EMT); there may be a molecular link between mitochondrial dysfunction and EMT induction PMID: 26781467
    6. NLRX1 and TUFM work in concert to reduce cytokine response and augment autophagy. PMID: 23321557
    7. Increased expression of TUFM is a promising new prognostic indicator for colorectal carcinoma. PMID: 22772342
    8. By recruiting Atg5-Atg12 and NLRX1, TUFM serves as a nodal checkpoint of the RIG-I-MAVS axis. It acts similarly to NLRX1 by inhibiting RigI-like-receptor-induced IFN-I but promoting autophagy. PMID: 22749352
    9. Genetic investigation of patients with defective mitochondrial translation led to the discovery of novel mutations in the mitochondrial elongation factor G1 (EFG1) in one affected baby and in the mitochondrial elongation factor Tu (EFTu) in another one PMID: 17160893
    10. Myoblasts isolated from the MELAS patients show A3243G mutation in tRNALeu(UUR) produces a severe respiratory chain deficiency and this phenotype can be partially suppressed by overexpression of EFTu and EFG2. PMID: 18753147
    11. Results suggest that the R336Q mutant mt-EFTu variant fails to bind to aminoacylated mitochondrial tRNAs, thus explaining the observed impairment of mitochondrial translation. PMID: 19524667

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Combined oxidative phosphorylation deficiency 4 (COXPD4)
  • 亞細(xì)胞定位:
    Mitochondrion.
  • 蛋白家族:
    TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 12420

    OMIM: 602389

    KEGG: hsa:7284

    STRING: 9606.ENSP00000322439

    UniGene: Hs.12084



主站蜘蛛池模板: 国产午夜精品一区二区三区不卡 | 蜜桃精品成人影片| 日韩精品无码一本二本三本色| 特黄特级毛片免费视频| 日本韩国的免费观看视频| av中文字幕无码免费看| 熟妇人妻中文字幕| 成人网站免费观看入口| 日韩欧国产精品一区综合无码| 粗大猛烈进出高潮视频| 狠狠躁18三区二区一区| 免费纯肉3d动漫无码网站| 亚洲国产成人精品无码区在线秒播 | 日本大片免a费观看视频| 欧美成人综合久久精品| 三级理论中文字幕在线播放| 亚洲精品嫩草研究院久久| 日韩欧美亚洲综合久久| 精品久久久久久久久久久国产字幕| 久久99亚洲含羞草影院| 色av专区无码影音先锋| 亚洲 欧美 变态 另类 综合| 天堂资源中文网| 夜晚被公侵犯的人妻深田字幕 | 免费人成视频| 国产乱xxxxx97国语对白| 超碰香蕉人人网99精品| 国产99视频精品免费视频6| 一边摸一边做爽的免费视频日本 | 2021自拍偷在线精品自拍偷| www一区二区www免费| 男人扒开女人双腿猛进视频| 精品国产av一区二区果冻传媒 | 国产精品免费视频色拍拍| 国产又粗又猛又爽又黄的视频在线观看动漫 | 亚洲人成色77777在线观看大战p| 精品国产sm最大网免费站| 丁香五月亚洲综合深深爱| 精品无码成人片一区二区| 窝窝午夜理论片影院| 亚洲午夜性猛春交xxxx|