在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TUFM Antibody

  • 中文名稱:
    TUFM兔多克隆抗體
  • 貨號:
    CSB-PA060027
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    TUFM
  • 別名:
    COXPD4 antibody; EF Tu antibody; EF TuMT antibody; EF-Tu antibody; EF-TuMT antibody; EFTu antibody; EFTU_HUMAN antibody; EFTuMT antibody; Elongation factor Tu antibody; Elongation factor Tu mitochondrial antibody; mitochondrial antibody; P43 antibody; Tu translation elongation factor; mitochondrial antibody; Tufm antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human EF-Tu.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.
  • 基因功能參考文獻:
    1. Novel mutation in mitochondrial Elongation Factor EF-Tu associated to dysplastic leukoencephalopathy and defective mitochondrial DNA translation. PMID: 28132884
    2. study revealed a novel role for TUFM as a host restriction factor that exerts an inhibitory effect on avian-signature PB2627E influenza virus propagation in human cells; found that increased TUFM-dependent autophagy correlates with the inhibitory effect on avian-signature influenza virus replication and may serve as a key intrinsic mechanism to restrict avian influenza virus infection in humans PMID: 28611246
    3. High expression of TUFM is associated with colorectal cancer. PMID: 28449687
    4. we identify a novel signaling hub centering on the NLRX1 TUFM protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM result in compromised autophagy when treated with EGFR inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR inhibitors. PMID: 26876213
    5. TUFM is a novel regulator of epithelial-mesenchymal transition (EMT); there may be a molecular link between mitochondrial dysfunction and EMT induction PMID: 26781467
    6. NLRX1 and TUFM work in concert to reduce cytokine response and augment autophagy. PMID: 23321557
    7. Increased expression of TUFM is a promising new prognostic indicator for colorectal carcinoma. PMID: 22772342
    8. By recruiting Atg5-Atg12 and NLRX1, TUFM serves as a nodal checkpoint of the RIG-I-MAVS axis. It acts similarly to NLRX1 by inhibiting RigI-like-receptor-induced IFN-I but promoting autophagy. PMID: 22749352
    9. Genetic investigation of patients with defective mitochondrial translation led to the discovery of novel mutations in the mitochondrial elongation factor G1 (EFG1) in one affected baby and in the mitochondrial elongation factor Tu (EFTu) in another one PMID: 17160893
    10. Myoblasts isolated from the MELAS patients show A3243G mutation in tRNALeu(UUR) produces a severe respiratory chain deficiency and this phenotype can be partially suppressed by overexpression of EFTu and EFG2. PMID: 18753147
    11. Results suggest that the R336Q mutant mt-EFTu variant fails to bind to aminoacylated mitochondrial tRNAs, thus explaining the observed impairment of mitochondrial translation. PMID: 19524667

    顯示更多

    收起更多

  • 相關疾病:
    Combined oxidative phosphorylation deficiency 4 (COXPD4)
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily
  • 數據庫鏈接:

    HGNC: 12420

    OMIM: 602389

    KEGG: hsa:7284

    STRING: 9606.ENSP00000322439

    UniGene: Hs.12084



主站蜘蛛池模板: 亚洲日本va午夜中文字幕久久| 狠狠色综合激情丁香五月| 国产精品沙发午睡系列990531| 色喜国模李晴超大尺度| 午夜无码片在线观看影院y| 亚洲国产精品无码久久sm| 国产乱人伦偷精品视频不卡| 国产区图片区小说区亚洲区| 伊人色综合久久天天网| 国产亚洲久久久久久久| 东京热人妻中文无码av| 中文在线а√天堂官网| 亚洲精品久久7777777国产| 老子影院无码午夜伦不卡| 99久久99久久精品国产片果冻 | 亚洲综合精品成人| 亚洲成a人片在线观看日本| 亚洲最新无码中文字幕久久 | 日韩av无码中文无码不卡电影| 久久婷婷五月综合色精品| 国内精品乱码卡一卡2卡三卡新区| 久久久精品94久久精品| 国产97色在线 | 亚洲| 欧美人与动牲交a欧美| 亚洲国产精品无码久久久蜜芽| 久热国产精品视频一区二区三区| 日本乱子人伦在线视频| 男女性潮高清免费网站| 亚洲熟女av乱码在线观看漫画| 中文字幕高清免费日韩视频在线 | 伊人色综合九久久天天蜜桃| 色狠狠色狠狠综合天天| 亚洲国产精品久久亚洲精品| 国产强奷在线播放免费| 久久精品国产99久久久| 狠狠色狠狠色综合日日不卡| 四虎影视88aa久久人妻| 少妇愉情理伦片丰满丰满| 国产女人和拘做受视频免费| 国产一区二区野外| 中文字幕 乱码 中文乱码视频|