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Recombinant Human Elongation factor Ts, mitochondrial (TSFM)

  • 中文名稱:
    人TSFM重組蛋白
  • 貨號:
    CSB-YP025124HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人TSFM重組蛋白
  • 貨號:
    CSB-EP025124HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人TSFM重組蛋白
  • 貨號:
    CSB-EP025124HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人TSFM重組蛋白
  • 貨號:
    CSB-BP025124HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人TSFM重組蛋白
  • 貨號:
    CSB-MP025124HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    TSFM
  • Uniprot No.:
  • 別名:
    COXPD 3; COXPD3; EF TS; EF Tsmt; EF-Ts; EF-TsMt; EFTS; EFTS_HUMAN; EFTSMT; Elongation factor Ts; Elongation factor Ts mitochondrial; HGNC12367; mitochondrial; Mitochondrial elongation factor Ts; Ts translation elongation factor mitochondrial; TSFM; TSMT
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區(qū)域:
    46-325
  • 氨基酸序列
    SKELL MKLRRKTGYS FVNCKKALET CGGDLKQAEI WLHKEAQKEG WSKAAKLQGR KTKEGLIGLL QEGNTTVLVE VNCETDFVSR NLKFQLLVQQ VALGTMMHCQ TLKDQPSAYS KGFLNSSELS GLPAGPDREG SLKDQLALAI GKLGENMILK RAAWVKVPSG FYVGSYVHGA MQSPSLHKLV LGKYGALVIC ETSEQKTNLE DVGRRLGQHV VGMAPLSVGS LDDEPGGEAE TKMLSQPYLL DPSITLGQYV QPQGVSVVDF VRFECGEGEE AAETE
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
  • 基因功能參考文獻:
    1. Different TSFM mutations can produce the same or very different clinical phenotypes, going from abortions to moderately severe presentations. On the other hand, the same TSFM mutation can also produce same or different phenotypes within the same range of presentations, therefore suggesting the involvement of unknown factors. PMID: 27677415
    2. show that in addition to early-onset cardiomyopathy, TSFM mutations should be considered in childhood and juvenile encephalopathies with optic and/or peripheral neuropathy, ataxia, or Leigh disease PMID: 25037205
    3. identified a homozygous mutation changing a highly conserved arginine into a tryptophan (R312W) in a kindred with intrauterine growth retardation, neonatal lactic acidosis, liver dysfunction and multiple respiratory chain deficiency in muscle PMID: 21741925
    4. Molecular modeling showed that the Arg333Trp substitution disrupts local subdomain structure and the dimerization interface. PMID: 17033963
  • 相關疾病:
    Combined oxidative phosphorylation deficiency 3 (COXPD3)
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    EF-Ts family
  • 組織特異性:
    Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and kidney.
  • 數據庫鏈接:

    HGNC: 12367

    OMIM: 604723

    KEGG: hsa:10102

    UniGene: Hs.632704



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