在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), partial

  • 中文名稱:
    人ENTPD5重組蛋白
  • 貨號:
    CSB-YP007694HU1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人ENTPD5重組蛋白
  • 貨號:
    CSB-EP007694HU1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人ENTPD5重組蛋白
  • 貨號:
    CSB-EP007694HU1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人ENTPD5重組蛋白
  • 貨號:
    CSB-BP007694HU1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人ENTPD5重組蛋白
  • 貨號:
    CSB-MP007694HU1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ENTPD5
  • Uniprot No.:
  • 別名:
    ENTPD5; CD39L4; PCPH; Ectonucleoside triphosphate diphosphohydrolase 5; NTPDase 5; CD39 antigen-like 4; ER-UDPase; Guanosine-diphosphatase ENTPD5; GDPase ENTPD5; Nucleoside diphosphatase; Uridine-diphosphatase ENTPD5; UDPase ENTPD5
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.
  • 基因功能參考文獻:
    1. ENTPD5 is a mediator of mutant p53 gain of function activity in clonogenic growth, architectural tissue remodeling, migration, invasion, and lung colonization in lung cancer and its mouse models PMID: 27956623
    2. Results suggest that ENTPD5 affects lung cancer apoptosis via Caspase 3 pathway, and can be potentially used to monitor prognosis or to guide appropriate therapeutic regimens. PMID: 25794010
    3. The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets. PMID: 25045656
    4. These results strongly suggest that the mt-PCPH ( ENTPD5)oncoprotein may regulate the cellular energy levels and subsequent chemoresistance by an NTPDase-independent mechanism PMID: 23921441
    5. Upregulation of ENTPD5 is associated with altered metabolism in gliomablastoma multiforme. PMID: 22992974
    6. The elevation of ENTPD5 activity therefore protects AKT-active cancer cells from protein-overloading-induced endoplasmic reticulum stress and the resulting growth arrest and apoptosis. PMID: 22169232
    7. Study reports that ENTPD5, an endoplasmic reticulum (ER) enzyme, is upregulated in cell lines and primary human tumor samples with active AKT. PMID: 21074248
    8. deregulation and loss of expression in the progression of laryngeal neoplasia [PCPH] PMID: 12489110
    9. Results positively identify PCPH as a good early molecular marker for testicular neoplasms, and strongly indicate that immunodetection of truncated PCPH polypeptides may be a useful diagnostic tool for testicular germ cell tumors. PMID: 16465363
    10. PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism PMID: 18006831
    11. Findings identify PCPH as an important participant in the chemotherapy response of prostate cancer cells and establish a role for PCPH-PKCalpha-Bcl-2 functional interactions in the drug response process. PMID: 19117992

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum. Secreted.
  • 蛋白家族:
    GDA1/CD39 NTPase family
  • 組織特異性:
    Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues.
  • 數據庫鏈接:

    HGNC: 3367

    OMIM: 603162

    KEGG: hsa:957

    STRING: 9606.ENSP00000335246

    UniGene: Hs.655070



主站蜘蛛池模板: 成人av在线一区二区三区| 国产无遮挡又爽又黄的视频| 精品精品国产理论在线观看| 女人国产香蕉久久精品| 天堂а在线中文在线新版| 成熟丰满熟妇高潮xxxxx| 国模无码视频一区| 又色又爽又黄的gif动态图| 宅男午夜成年影视在线观看| 白嫩少妇bbw撒尿视频| 国产良妇出轨视频在线观看| 色欲av永久无码精品无码蜜桃| 久久精品国产99国产精偷| 国产福利日本一区二区三区| 成+人+网+站+免费观看| 2018天天拍拍天天爽视频| 亚洲精品欧美二区三区中文字幕| 亚洲字幕av一区二区三区四区 | 国产精品嫩草影院入口一二三| 强奷乱码中文字幕熟女一| 中文字幕无码免费不卡视频| 国产在线欧美日韩精品一区| 亚洲全部无码中文字幕| 顶级欧美熟妇xx| 欧美亅性猛交内射| 国产精成a品人v在线播放| 色综合视频一区二区三区44| 黑人巨茎美女高潮视频| 久久综合亚洲鲁鲁五月天| 亚洲精品一本之道高清乱码| 欧美午夜成人片在线观看| 欧美日韩午夜群交多人轮换| 免费无遮挡禁18污污网站| 久久精品99无色码中文字幕| 色综合久久久久久久久五月| 日本乱子人伦在线视频| 永久免费的无码中文字幕| 国产亚洲日韩欧美另类丝瓜app| 中国china露脸自拍性hd| 三男一女吃奶添下面视频| 久久无码无码久久综合综合|