在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ENTPD5 Antibody

ENTPD5 Antibody

  • 中文名稱：
    ENTPD5兔多克隆抗體
  • 貨號：
    CSB-PA929748
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA929748(ENTPD5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA929748(ENTPD5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: CSB-PA929748(ENTPD5 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ENTPD5
  • 別名：
    ENTPD5; CD39L4; PCPH; Ectonucleoside triphosphate diphosphohydrolase 5; NTPDase 5; CD39 antigen-like 4; ER-UDPase; Guanosine-diphosphatase ENTPD5; GDPase ENTPD5; Nucleoside diphosphatase; Uridine-diphosphatase ENTPD5; UDPase ENTPD5
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ENTPD5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.
  • 基因功能參考文獻：
    1. ENTPD5 is a mediator of mutant p53 gain of function activity in clonogenic growth, architectural tissue remodeling, migration, invasion, and lung colonization in lung cancer and its mouse models PMID: 27956623
    2. Results suggest that ENTPD5 affects lung cancer apoptosis via Caspase 3 pathway, and can be potentially used to monitor prognosis or to guide appropriate therapeutic regimens. PMID: 25794010
    3. The main point of this review is to integrate the findings and proposed theories about the role played by NTPDase5/mt-PCPH in cancer progression, considering that these proteins have been suggested as potential early diagnostic tools and therapy targets. PMID: 25045656
    4. These results strongly suggest that the mt-PCPH ( ENTPD5)oncoprotein may regulate the cellular energy levels and subsequent chemoresistance by an NTPDase-independent mechanism PMID: 23921441
    5. Upregulation of ENTPD5 is associated with altered metabolism in gliomablastoma multiforme. PMID: 22992974
    6. The elevation of ENTPD5 activity therefore protects AKT-active cancer cells from protein-overloading-induced endoplasmic reticulum stress and the resulting growth arrest and apoptosis. PMID: 22169232
    7. Study reports that ENTPD5, an endoplasmic reticulum (ER) enzyme, is upregulated in cell lines and primary human tumor samples with active AKT. PMID: 21074248
    8. deregulation and loss of expression in the progression of laryngeal neoplasia [PCPH] PMID: 12489110
    9. Results positively identify PCPH as a good early molecular marker for testicular neoplasms, and strongly indicate that immunodetection of truncated PCPH polypeptides may be a useful diagnostic tool for testicular germ cell tumors. PMID: 16465363
    10. PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism PMID: 18006831
    11. Findings identify PCPH as an important participant in the chemotherapy response of prostate cancer cells and establish a role for PCPH-PKCalpha-Bcl-2 functional interactions in the drug response process. PMID: 19117992

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endoplasmic reticulum. Secreted.
  • 蛋白家族：
    GDA1/CD39 NTPase family
  • 組織特異性：
    Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3367

    OMIM: 603162

    KEGG: hsa:957

    STRING: 9606.ENSP00000335246

    UniGene: Hs.655070



主站蜘蛛池模板： 一道久久爱综合久久爱| 国产免费无遮挡吸奶头视频 | 国产精品高清不卡在线播放| 天天澡天天揉揉av在线| 在线观看成人年视频免费| 中国做爰国产精品视频| 国产精品系列无码专区| 免费人成在线观看网站| 久久人人爽av亚洲精品天堂| 国产精品久久久久久妇女| 狼色精品人妻在线视频免费| 日韩av中文无码影院| 亚洲人成日韩中文字幕无卡| 无码国产成人午夜电影在线观看| 九九九免费观看视频| 色欲精品国产一区二区三区av| 久久久青草青草免费看| 鲁一鲁一鲁一鲁一曰综合网| 亚洲精品亚洲人成在线下载| 人妻少妇精品久久久久久| 手机看片福利一区二区三区| 国产成人亚洲精品无码电影| 日韩精品亚洲aⅴ在线影院 | 成年女人永久免费观看视频| 97色偷偷色噜噜狠狠爱网站97| 免费人成视频网站在线下载| 内射一区二区精品视频在线观看| 青草青草视频2免费观看| 国产麻花豆剧传媒精品mv在线 | 国产高潮抽搐喷水高清| 色综合欧美五月俺也去| 亚洲精品成人网站在线观看| 中文字幕日韩一区二区三区不卡| 亚洲人成网站在线播放2019| 亚洲精品乱码一区二区三区| 欧美欧洲成本大片免费| 日本少妇高潮喷水xxxxxxx| 色老久久精品偷偷鲁| 国语自产拍精品香蕉在线播放| 国产av无码精品色午夜| 国产人妻人伦精品|