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  4. Recombinant Human Echinoderm microtubule-associated protein-like 1 (EML1), partial

Recombinant Human Echinoderm microtubule-associated protein-like 1 (EML1), partial

  • 中文名稱：
    人EML1重組蛋白
  • 貨號：
    CSB-YP007642HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人EML1重組蛋白
  • 貨號：
    CSB-EP007642HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人EML1重組蛋白
  • 貨號：
    CSB-EP007642HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人EML1重組蛋白
  • 貨號：
    CSB-BP007642HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人EML1重組蛋白
  • 貨號：
    CSB-MP007642HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    EML1
  • Uniprot No.：
  • 別名：
    echinoderm microtubule associated protein like 1; Echinoderm microtubule-associated protein-like 1; ELP79; EMAL1_HUMAN; EMAP; EMAP-1; EMAPL; Eml1; FLJ45033; HuEMAP; HuEMAP-1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
  • 基因功能參考文獻：
    1. a homozygous truncating variant in EML1 is a novel cause of congenital hydrocephalus. PMID: 28556411
    2. We show that the trimerization domain (TD) of EML1 is necessary and sufficient for self-association. The TD is also essential for MT binding; however, this property requires an adjacent basic region. PMID: 25740311
    3. We found EML1 to be mutated in ribbon-like heterotopia in humans PMID: 24859200
    4. determined a 2.6-A crystal structure of the representative approximately 70-kDa core of EML1, revealing an intimately associated pair of beta-propellers, which we term a TAPE (tandem atypical propeller in EMLs) domain PMID: 24706829
  • 相關疾病：
    Band heterotopia (BH)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    WD repeat EMAP family
  • 組織特異性：
    Ubiquitous; expressed in most tissues with the exception of thymus and peripheral blood lymphocytes.
  • 數據庫鏈接：

    HGNC: 3330

    OMIM: 600348

    KEGG: hsa:2009

    STRING: 9606.ENSP00000334314

    UniGene: Hs.12451



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