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  4. EML1 Antibody

EML1 Antibody

  • 中文名稱：
    EML1兔多克隆抗體
  • 貨號：
    CSB-PA007642GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    EML1
  • 別名：
    echinoderm microtubule associated protein like 1 antibody; Echinoderm microtubule-associated protein-like 1 antibody; ELP79 antibody; EMAL1_HUMAN antibody; EMAP antibody; EMAP-1 antibody; EMAPL antibody; Eml1 antibody; FLJ45033 antibody; HuEMAP antibody; HuEMAP-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human EML1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
  • 基因功能參考文獻：
    1. a homozygous truncating variant in EML1 is a novel cause of congenital hydrocephalus. PMID: 28556411
    2. We show that the trimerization domain (TD) of EML1 is necessary and sufficient for self-association. The TD is also essential for MT binding; however, this property requires an adjacent basic region. PMID: 25740311
    3. We found EML1 to be mutated in ribbon-like heterotopia in humans PMID: 24859200
    4. determined a 2.6-A crystal structure of the representative approximately 70-kDa core of EML1, revealing an intimately associated pair of beta-propellers, which we term a TAPE (tandem atypical propeller in EMLs) domain PMID: 24706829
  • 相關疾病：
    Band heterotopia (BH)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    WD repeat EMAP family
  • 組織特異性：
    Ubiquitous; expressed in most tissues with the exception of thymus and peripheral blood lymphocytes.
  • 數據庫鏈接：

    HGNC: 3330

    OMIM: 600348

    KEGG: hsa:2009

    STRING: 9606.ENSP00000334314

    UniGene: Hs.12451



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