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  4. Recombinant Human Early endosome antigen 1 (EEA1), partial

Recombinant Human Early endosome antigen 1 (EEA1), partial

  • 中文名稱：
    人EEA1重組蛋白
  • 貨號：
    CSB-YP007405HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人EEA1重組蛋白
  • 貨號：
    CSB-EP007405HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人EEA1重組蛋白
  • 貨號：
    CSB-EP007405HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人EEA1重組蛋白
  • 貨號：
    CSB-BP007405HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人EEA1重組蛋白
  • 貨號：
    CSB-MP007405HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Early endosome antigen 1; Early endosome antigen 1; 162kD; Early endosome associated protein; EEA 1; EEA1; EEA1_HUMAN; Endosome associated protein p162; Endosome-associated protein p162; MST105; MSTP105; ZFYVE2; Zinc finger FYVE domain containing protein 2; Zinc finger FYVE domain-containing protein 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
  • 基因功能參考文獻：
    1. This also suggests that this pathway is involved in EEA1-vesicles biogenesis. PMID: 30188634
    2. identification of allergic bronchopulmonary aspergillosis -associated variants in EEA that have functional effects on macrophage phagocytosis and phagolysosome acidification of A. fumigatus conidia. PMID: 29547649
    3. results suggest a new mechanism in which Rab5 induces a change in flexibility of EEA1, generating an entropic collapse force that pulls the captured vesicle towards the target membrane to initiate docking and membrane fusion PMID: 27556945
    4. EEA1 mobility on endosomes is decreased upon stimulation of EGF receptor endocytosis in HeLa cells PMID: 26993163
    5. Under the regulation of Rab5, the fused vesicles are targeted to early endosomes and thus deliver the internalized TbetaRI to the caveolin-1 and EEA1 double-positive early endosomes (caveolin-1-positive early endosomes). PMID: 25998683
    6. In serum-deprivated HeLa cells with low endocytic activity there two types of EEA1-vesicles: the first one carries the both EEA1 and Rab5 at high levels; the second consists of weakly decorated EEA1-vesicles that can be both Rab5-positive and -negative. PMID: 25711083
    7. Data indicate that early endosome antigen 1 (EEA1) is important for the small GTPase Rab31-mediated enhancement of ligand-bound EGF receptor (EGFR) endocytic trafficking. PMID: 24644286
    8. nuclear uptake of Abeta involves the dynamin-dependent EEA1 and TGF-beta/Smad signaling pathways. PMID: 24491918
    9. We therefore propose that the N1072K variant of the EEA1 gene is a candidate mutation for susceptibility to diabetes in the Japanese population. PMID: 23499280
    10. EEA1 interacts with Phafin2 and colocolizes with Phafin2 in endosome membrane. PMID: 22816767
    11. NMR analyses of the interaction between the FYVE domain of early endosome antigen 1 (EEA1) and phosphoinositide embedded in a lipid bilayer. PMID: 22915584
    12. p97 inhibition causes increased EEA1 self-association at the endosome membrane. PMID: 21556036
    13. The knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via the attenuated phosphorylation of Akt, independent of the effects of EEA1. PMID: 21468601
    14. crystal structure of Rab5A in complex with the EEA1 C(2)H(2) zinc finger PMID: 20534488
    15. activation of p38 MAPK caused a decrease in EEA1 colocalization with phagosomes, arresting maturation into the phagolysosome PMID: 12963735
    16. macropinosomes do not mature to late endosomes or fuse with lysosomes. EEA1 continuously mediates homotypic fusion as long as the macropinosomes persist. PMID: 15052657
    17. These results suggest that EEA1 is involved in neuronal synaptic vesicle function and axonal transport and growth. EEA1 may undergo calcium-dependent conformational changes that are required for binding to SNAP-25. PMID: 15451443
    18. Results describe the geometry of the micelle penetration of the early endosome antigen 1 FYVE domain. PMID: 16331966
    19. PIKfyve is distributed in microdomains that are distinct from those occupied by EEA1 and Hrs PMID: 16448788
    20. Impairment of internalization of specific glutamate receptors and their subsequent accumulation in the synapse may account for the neurological deficits observed in some patients developing EEA1 autoantibodies. PMID: 17113235
    21. results suggest that the local production of PtdIns(3)P implicates the fusion of macropinosomes via EEA1 as well as conventional early endosomes PMID: 17146146

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  • 亞細胞定位：
    Cytoplasm. Early endosome membrane; Peripheral membrane protein.
  • 數據庫鏈接：

    HGNC: 3185

    OMIM: 605070

    KEGG: hsa:8411

    STRING: 9606.ENSP00000317955

    UniGene: Hs.567367



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