在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human ETS-related transcription factor Elf-5 (ELF5)

  • 中文名稱:
    人ELF5重組蛋白
  • 貨號:
    CSB-YP891540HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人ELF5重組蛋白
  • 貨號:
    CSB-EP891540HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人ELF5重組蛋白
  • 貨號:
    CSB-EP891540HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人ELF5重組蛋白
  • 貨號:
    CSB-BP891540HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人ELF5重組蛋白
  • 貨號:
    CSB-MP891540HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ELF5
  • Uniprot No.:
  • 別名:
    E74 like factor 5 (ets domain transcription factor); E74 like factor 5; E74-like factor 5; ELF 5; ELF5; ELF5_HUMAN; Epithelium restricted ESE 1 related Ets factor; Epithelium restricted ESE1 related Ets factor; Epithelium specific Ets transcription factor 2; Epithelium-restricted ESE-1-related Ets factor; Epithelium-specific Ets transcription factor 2; ESE 2; ESE-2; ESE2; Ets domain TF; Ets domain transcription factor; ETS related transcription factor Elf 5; ETS related transcription factor Elf5; ETS-related transcription factor Elf-5
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-265
  • 氨基酸序列
    MPSLPHSHRV MLDSVTHSTF LPNASFCDPL MSWTDLFSNE EYYPAFEHQT ACDSYWTSVH PEYWTKRHVW EWLQFCCDQY KLDTNCISFC NFNISGLQLC SMTQEEFVEA AGLCGEYLYF ILQNIRTQGY SFFNDAEESK ATIKDYADSN CLKTSGIKSQ DCHSHSRTSL QSSHLWEFVR DLLLSPEENC GILEWEDREQ GIFRVVKSEA LAKMWGQRKK NDRMTYEKLS RALRYYYKTG ILERVDRRLV YKFGKNAHGW QEDKL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.; Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.
  • 基因功能參考文獻:
    1. Elf5 expression was associated with decreased overall and disease-free survival of triple negative breast cancers patients. PMID: 29396764
    2. When ELF5 was transfected into the parental MCF7 cells that lack CEACAM1, lumen formation was restored, indicating that ELF5 can replace CEACAM1 in this model system of lumenogenesis. PMID: 28800960
    3. These results support the contention that ABO expression is dependent upon a downstream positive regulatory element functioning through a tissue-restricted transcription factor, Elf5, in epithelial cells. PMID: 27587399
    4. Low ELF5 expression is associated with ovarian cancer. PMID: 28184931
    5. The results of this study suggest that ELF5 is a candidate gene that confers genetic susceptibility for pediatric asthma in the Taiwanese population and SNP rs3910901 may have a minor impact on pediatric asthma in the Taiwanese population. PMID: 25648666
    6. a novel EWSR1/ETS chimeric gene, was identified in a patient diagnosed with refractory AML, suggesting a potential role of leukemogenesis in rare cases of AML. This fusion gene is very likely to exhibit oncogenic potential by interfering with the p53/p21-dependent pathway. PMID: 27627705
    7. Alternative promoter use, conferring differential regulatory responses, is the main mechanism governing ELF5 action rather than differential transcriptional activity of the isoforms. PMID: 26738740
    8. Data (including data from studies in transgenic mice) suggest that expression of ELF5 in luminal breast cancer correlates with increased myeloid cell invasion, inflammation, and lung metastasis. PMID: 26717410
    9. we identified Elf5 as a novel biomarker of urothelial cancer on several biological levels and established a causative link between Elf5 and epithelial-mesenchymal transition in urothelial cancer. PMID: 25629735
    10. Elf5 expression is inversely correlated with epithelial-mesenchymal transition in prostate cancer. PMID: 25728398
    11. ELF5 provides a key transcriptional determinant of breast cancer molecular subtype by suppression of estrogen sensitivity in luminal breast cancer cells. PMID: 23300383
    12. Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. PMID: 23086238
    13. Loss of ELF5 is associated with kidney cancer. PMID: 21787113
    14. ELF5 is expressed in the human placenta in villous cytotrophoblast cells but not in post-mitotic syncytiotrophoblast and invasive extravillous cytotrophoblast cells. PMID: 20354077
    15. findings show that Ese-2 upregulates K18 gene expression through specific interactions within ETS binding sites in the regulatory first intron of the gene PMID: 15987600
    16. Our studies have identified a critical stretch of nucleotides that is important for both basal as well as calcium responsive reporter activity and that binds to a nuclear factor, keratinocyte restricted factor (KRF). PMID: 16229011
    17. Identification of the ESE-2 consensus site and characterization of the transcriptional activation properties of ESE-2 shed new light on its potential as a regulator of target genes. PMID: 16704374

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    ETS family
  • 組織特異性:
    Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tiss
  • 數據庫鏈接:

    HGNC: 3320

    OMIM: 605169

    KEGG: hsa:2001

    STRING: 9606.ENSP00000311010

    UniGene: Hs.11713



主站蜘蛛池模板: 欧美人与动性xxxxx杂性| 亚洲午夜av久久久精品影院色戒 | 精品无人码麻豆乱码1区2区| 极品少妇被啪到呻吟喷水| 欧美性开放情侣网站| 吃奶摸下高潮60分钟免费视频| 国产人成无码视频在线1000 | 青草影院内射中出高潮-百度| 草裙社区精品视频三区免费看 | 大战熟女丰满人妻av| 国产亚洲熟妇在线视频| 日韩99在线 | 中文| 青草草在线视频永久免费| 国产又猛又黄又爽| 久久人妻xunleige无码| 国产成人一区二区不卡免费视频| 夜夜高潮夜夜爽高清完整版1| 国产高清狼人香蕉在线| 国产极品久久久久久久久| 熟女肥臀白浆大屁股一区二区 | 亚洲国产精品无码中文字2022 | 3d动漫精品一区二区三区| 99久热re在线精品视频| 美国人性欧美xxxx| 欧美成人精品三级网站| 免费一本色道久久一区| 麻豆国产成人av在线播放欲色 | 国产成a人亚洲精v品无码| 午夜亚洲国产理论片中文飘花| 五月天精品视频在线观看| 永久免费的av在线电影网无码| 强被迫伦姧惨叫人妻系列| 久久亚洲色www成人不卡| 狠狠躁天天躁夜夜躁婷婷| 中文字幕乱码一区av久久不卡| 亚洲熟妇av一区二区三区宅男| 久久精品亚洲中文字幕无码网站| 色av综合av综合无码网站| 精品高朝久久久久9999| 大胆日本熟妇xxxx| 国产午国产午夜精华 免费|