在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human E3 ubiquitin-protein ligase pellino homolog 3 (PELI3)

In Stock
  • 中文名稱:
    人PELI3重組蛋白
  • 貨號:
    CSB-EP847618HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    PELI3
  • Uniprot No.:
  • 別名:
    E3 ubiquitin protein ligase pellino homolog 3; MGC35521; PEL 13; Peli3; PELI3_HUMAN; Pellino 3 ; Pellino 3 alpha; Pellino E3 ubiquitin protein ligase family member 3; Pellino homolog 3 (Drosophila); Pellino-3; Protein pellino homolog 3
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    54.8 kDa
  • 表達區域:
    1-469aa
  • 氨基酸序列
    MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKYGELIVLGCCEEGGEETEAQRGEVTGPRAHSCYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGGAAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.
  • 基因功能參考文獻:
    1. Two protective, low-frequency, non-synonymous variants were significantly associated with a decrease in age-related macular degeneration (AMD)risk: A307V in PELI3 and N1050Y in CFH .We also identified a strong protective signal for a common variant (rs8056814) near CTRB1 associated with a decrease in AMD risk (logistic regression: OR = 0.71, P = 1.8 x 10-07). PMID: 28011711
    2. The combination of low Pellino3 levels together with high and inducible Pellino1 expression may be an important determinant of the degree of inflammation triggered upon Toll-like receptor 2 engagement by Helicobacter pylori and/or its components, contributing to Helicobacter pylori-associated pathogenesis by directing the incoming signal toward an NF-kB-mediated proinflammatory response. PMID: 27302665
    3. Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling. PMID: 26310831
    4. Peptide PEL3 derived from the interleukin-1 receptor-associated kinase (IRAK)1-binding motif reveals a distinct phosphothreonine peptide binding preference. PMID: 25027698
    5. Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation. PMID: 23892723
    6. Pellino3 is a novel upstream regulator of p38 MAPK that activates CREB in a p38-dependent manner PMID: 15917247
    7. suggest that Pellino 3b acts as a negative regulator for IL-1 signaling by regulating IRAK degradation through its ubiquitin protein ligase activity [Pellino 3b] PMID: 18326498

    顯示更多

    收起更多

  • 蛋白家族:
    Pellino family
  • 組織特異性:
    Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung.
  • 數據庫鏈接:

    HGNC: 30010

    OMIM: 609827

    KEGG: hsa:246330

    STRING: 9606.ENSP00000322532

    UniGene: Hs.656875



主站蜘蛛池模板: av无码小缝喷白浆在线观看| 久久av无码αv高潮αv喷吹| 7777精品伊人久久久大香线蕉| 极品粉嫩国产18尤物在线观看| 欧美肥老太牲交| 欧美三级在线播放线观看| 激情五月婷婷| 亚洲最大的成人网站| 99视频精品全部免费免费观看| 中文字幕aⅴ在线视频| 一本一道久久综合狠狠老| 欧美三级欧美成人高清| 亚洲日韩穿丝袜在线推荐| 亚洲国产欧美在线人成最新| 女人被男人爽到呻吟的视频| 国产精品老熟女露脸视频| 亚洲欧洲精品无码av| 国产成人a∨激情视频厨房| 天天av天天爽无码中文| 国产精品亚洲精品一区二区| 五 月 丁 香 综合中文| 国产亚洲精品久久久久久久 | 亚洲欧美日韩国产综合v| 4hu四虎永久在线影院| 九九精品99久久久香蕉| 国产福利视频| 最新国产精品精品视频| 国产美女精品视频线免费播放| 国产欠欠欠18一区二区| 久艹视频免费看| 欧洲专线一区二区三区| 亚洲高清最新av网站| 国产av无码专区亚洲精品| 日本伦奷在线播放| 久久久久人妻一区精品性色av| 国产午夜伦鲁鲁| 老司机久久一区二区三区| 大胸少妇午夜三级| 色先锋av影音先锋在线| 国产做爰xxxⅹ久久久小说| 成人亚洲国产精品一区不卡|