在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human E3 ubiquitin-protein ligase TRIP12 (TRIP12), partial

  • 中文名稱:
    人TRIP12重組蛋白
  • 貨號:
    CSB-YP617924HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人TRIP12重組蛋白
  • 貨號:
    CSB-EP617924HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人TRIP12重組蛋白
  • 貨號:
    CSB-MP617924HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    TRIP12; KIAA0045; ULF; E3 ubiquitin-protein ligase TRIP12; EC 2.3.2.26; E3 ubiquitin-protein ligase for Arf; ULF; HECT-type E3 ubiquitin transferase TRIP12; Thyroid receptor-interacting protein 12; TR-interacting protein 12; TRIP-12
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Mediates ubiquitination of ASXL1: following binding to N(6)-methyladenosine methylated DNA, ASXL1 is ubiquitinated by TRIP12, leading to its degradation and subsequent inactivation of the PR-DUB complex.
  • 基因功能參考文獻:
    1. p16 overexpression led to downregulation of TRIP12, which in turn led to increased RNF168 levels, repressed DNA damage repair (DDR), increased 53BP1 foci and enhanced radioresponsiveness. PMID: 27425591
    2. We describe the TRIP12-associated phenotype, showing that TRIP12 is a risk gene for non-syndromic intellectual disability with and without autism spectrum disorder, and that TRIP12 mutation carriers present with a broad phenotypic range within the neurodevelopmental phenotypes. PMID: 27848077
    3. nine presented pathogenic variants further document that TRIP12 haploinsufficiency causes a childhood-onset neurodevelopmental disorder PMID: 28251352
    4. Data indicate that E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 (TRIP12) promotes proteasomal degradation of pancreas transcription factor 1a (PTF1a)and regulates PTF1a activities. PMID: 25355311
    5. An exon3-skipping event in TRIP12 was detected in acute myeloid leukemia patients at remission PMID: 24961348
    6. HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin. PMID: 23209776
    7. Study shows that TRIP12 and UBR5, two HECT domain ubiquitin E3 ligases, control accumulation of RNF168, a rate-limiting component of a pathway that ubiquitylates histones after DNA breakage. PMID: 22884692
    8. data indicate that TRADD shuttles dynamically from the cytoplasm into the nucleus to modulate the interaction between p19(Arf) and its E3 ubiquitin ligase ULF, thereby promoting p19(Arf) protein stability and tumour suppression PMID: 22561347
    9. ULF is a bona fide E3 ligase for ARF and also suggest that ULF is an important target for activating the ARF-p53 axis in human acute myeloid leukaemia cells. PMID: 20699639
    10. Data show that the mechanism of BAF155-mediated stabilization of BAF57 involves blocking its ubiquitination by preventing interaction with TRIP12. PMID: 20829358
    11. TRIP12 promotes degradation of APP-BP1 by catalyzing its ubiquitination, which in turn modulates the neddylation pathway. PMID: 18627766
    12. The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway. PMID: 19028681

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleoplasm.
  • 蛋白家族:
    UPL family, K-HECT subfamily
  • 數據庫鏈接:

    HGNC: 12306

    OMIM: 604506

    KEGG: hsa:9320

    STRING: 9606.ENSP00000283943

    UniGene: Hs.572642



主站蜘蛛池模板: 精品国产一区二区三区香蕉| 人妻出轨av中文字幕| 久久成人国产精品免费| 久久久久 亚洲 无码 av 专区| 越南女子杂交内射bbwxz| 九九精品无码专区免费| 亚洲精品成人无码中文毛片不卡| 国产av一区二区三区天堂综合网| 大屁股国产白浆一二区| 国产全肉乱妇杂乱视频| 亚洲欧美乱综合图片区小说区| 97色偷偷色噜噜狠狠爱网站 | 人妻无码vs中文字幕久久av爆| 亚洲美女被黑人巨大在线播放| www国产精品内射熟女| 麻豆亚洲国产成人精品无码区 | 国内揄拍国产精品人妻门事件| 国精品午夜福利视频| 日韩不卡1卡2卡三卡网站| 欧美性xxxxx极品老少| 精品无码人妻一区二区三区品 | 中国丰满熟妇av| 久久久亚洲精品一区二区三区浴池| 中文字幕丰满乱孑伦无码专区| 肉感饱满中年熟妇日本| 日本边添边摸边做边爱边| 久久综合给合久久狠狠狠97色 | 日本一区二区a√成人片| 成人无遮挡裸免费视频在线观看| 精精国产xxxx视频在线| 图片区小说区激情区偷拍区| 在线人成免费视频69国产| 中文无码精品一区二区三区| 国产精品无码无在线观看| 日本中文字幕一区二区有码在线| 老子影院无码午夜伦不卡| 亚洲亚洲人成网站网址| 无码熟熟妇丰满人妻啪啪| 国产精成人品日日拍夜夜| 爆乳女仆高潮在线观看| 中文字幕人妻被公上司喝醉在线|