在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human E3 ubiquitin-protein ligase HECW2 (HECW2), partial

  • 中文名稱:
    人HECW2重組蛋白
  • 貨號:
    CSB-YP889188HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人HECW2重組蛋白
  • 貨號:
    CSB-EP889188HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人HECW2重組蛋白
  • 貨號:
    CSB-EP889188HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人HECW2重組蛋白
  • 貨號:
    CSB-BP889188HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人HECW2重組蛋白
  • 貨號:
    CSB-MP889188HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    HECW2
  • Uniprot No.:
  • 別名:
    C2 and WW domain-containing protein 2; E3 ubiquitin protein ligase HECW2; E3 ubiquitin-protein ligase HECW2; HECT; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; Hecw2; HECW2_HUMAN; KIAA130; KIAA1301; NEDD4 like E3 ubiquitin protein ligase 2; NEDD4 Related E3 Ubiquitin Ligase; NEDD4-like E3 ubiquitin-protein ligase 2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition.
  • 基因功能參考文獻:
    1. Results show that HECW2 interacts with two lamin A-binding proteins: proliferating cell nuclear antigen (PCNA), via a canonical PCNA-interacting protein (PIP) motif, and lamin B1. HECW2 mediates their ubiquitination and targets them for proteasomal degradation. PMID: 29753763
    2. HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT-like 1 (AMOTL1) stability. PMID: 27498087
    3. HECW2 is an ubiquitin ligase that stabilises p73, a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans. PMID: 27389779
    4. This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified. PMID: 27334371
    5. Low HECW2 expression is associated with cervical cancer. PMID: 25156441
    6. NEDL2 is a novel substrate of APC/C-Cdh1 as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition PMID: 24163370

    顯示更多

    收起更多

  • 相關疾病:
    Neurodevelopmental disorder with hypotonia, seizures, and absent language (NDHSAL)
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton, spindle.
  • 組織特異性:
    Predominantly expressed in adult brain, lung and heart.
  • 數據庫鏈接:

    HGNC: 29853

    OMIM: 617245

    KEGG: hsa:57520

    STRING: 9606.ENSP00000260983

    UniGene: Hs.633212



主站蜘蛛池模板: 色欲久久综合亚洲精品蜜桃 | 国产sm调教折磨视频失禁| 国产三级精品三级在线专1| 国产精品麻豆成人av电影艾秋 | 久久久性色精品国产免费观看| 久久精品亚洲精品国产色婷| 大胸美女污污污www网站| 四虎www永久在线精品| 大黑人交xxxx18视频| 精品久久久久久无码人妻热| 精品久久久久久无码免费| 99re8精品视频热线观看| 国产av午夜精品一区二区三| 污污内射久久一区二区欧美日韩| 国产亚洲情侣一区二区无| 亚洲已满18点击进入在线观看 | 内射小寡妇无码| 被黑人猛躁10次高潮视频| 亚洲熟妇av乱码在线观看| 538prom精品视频在线播放| 日韩国产亚洲高清在线久草| 亚洲一区二区三区四区五区六| 国产精品视频白浆免费视频| 国产清纯白嫩初高生在线观看| 免费观看男女性高视频| 色婷婷综合久久久久中文| 亚洲日本中文字幕天天更新| 亚洲日韩看片成人无码| √天堂中文最新版在线中文| 国产午夜视频在线观看| 伊人大香人妻在线播放| 99热网址最新获取域名| 免费人成视频在线观看网站| 337p日本欧洲亚洲大胆色噜噜| 97人妻免费碰视频碰免 | 久久精品国产丝袜人妻| 欧美真人性野外做爰| 色伦专区97中文字幕| 苍井空一区二区波多野结衣av| 国产人妻人伦精品1国产 | 真人一进一出120秒试看|