Recombinant Human Dual serine/threonine and tyrosine protein kinase (DSTYK), partial

中文名稱：

人DSTYK重組蛋白
貨號：

CSB-YP007213HU
規格：
來源：

Yeast
其他：

中文名稱：

人DSTYK重組蛋白
貨號：

CSB-EP007213HU
規格：
來源：

E.coli
其他：

中文名稱：

人DSTYK重組蛋白
貨號：

CSB-EP007213HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人DSTYK重組蛋白
貨號：

CSB-BP007213HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人DSTYK重組蛋白
貨號：

CSB-MP007213HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

DSTYK
Uniprot No.：

Q6XUX3
別名：

DSTYK; Dual serine/threonine and tyrosine protein kinase; Dusty PK; Dusty protein kinase; DUSTY_HUMAN; HDCMD38P; KIAA0472; Receptor interacting protein 5; Receptor interacting protein kinase 5; Receptor interacting serine/threonine protein kinase 5; Receptor-interacting serine/threonine-protein kinase 5; RIP homologous kinase; RIP-homologous kinase; RIP5; RIPK5; SgK496; Sugen kinase 496
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
基因功能參考文獻：
1. RIPK3 promotes adenovirus type 5 oncolytic activity. PMID: 29238045
2. we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK in all four affected family members with Autosomal-Recessive Complicated Spastic Paraparesis, SPG23 PMID: 28157540
3. We detected independent DSTYK mutations in 2.3% of patients with congenital abnormalities of the kidney or urinary tract, a finding that suggests that DSTYK is a major determinant of human urinary tract development, downstream of FGF signaling. PMID: 23862974
4. Confocal imaging of transiently expressed human Dusty-GFP fusion proteins showed a cytoplasmic distribution. PMID: 17123648
相關疾病：

Congenital anomalies of the kidney and urinary tract 1 (CAKUT1); Spastic paraplegia 23 (SPG23)
亞細胞定位：

Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family
組織特異性：

Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional
數據庫鏈接：

HGNC: 29043

OMIM: 270750

KEGG: hsa:25778

STRING: 9606.ENSP00000356130

UniGene: Hs.6874