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  4. DSTYK Antibody

DSTYK Antibody

  • 中文名稱：
    DSTYK兔多克隆抗體
  • 貨號：
    CSB-PA007213ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA007213ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA007213ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DSTYK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DSTYK
  • 別名：
    DSTYK antibody; Dual serine/threonine and tyrosine protein kinase antibody; Dusty PK antibody; Dusty protein kinase antibody; DUSTY_HUMAN antibody; HDCMD38P antibody; KIAA0472 antibody; Receptor interacting protein 5 antibody; Receptor interacting protein kinase 5 antibody; Receptor interacting serine/threonine protein kinase 5 antibody; Receptor-interacting serine/threonine-protein kinase 5 antibody; RIP homologous kinase antibody; RIP-homologous kinase antibody; RIP5 antibody; RIPK5 antibody; SgK496 antibody; Sugen kinase 496 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Dual serine/threonine and tyrosine protein kinase protein (680-929AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
  • 基因功能參考文獻：
    1. RIPK3 promotes adenovirus type 5 oncolytic activity. PMID: 29238045
    2. we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK in all four affected family members with Autosomal-Recessive Complicated Spastic Paraparesis, SPG23 PMID: 28157540
    3. We detected independent DSTYK mutations in 2.3% of patients with congenital abnormalities of the kidney or urinary tract, a finding that suggests that DSTYK is a major determinant of human urinary tract development, downstream of FGF signaling. PMID: 23862974
    4. Confocal imaging of transiently expressed human Dusty-GFP fusion proteins showed a cytoplasmic distribution. PMID: 17123648
  • 相關疾病：
    Congenital anomalies of the kidney and urinary tract 1 (CAKUT1); Spastic paraplegia 23 (SPG23)
  • 亞細胞定位：
    Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 組織特異性：
    Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional
  • 數據庫鏈接：

    HGNC: 29043

    OMIM: 270750

    KEGG: hsa:25778

    STRING: 9606.ENSP00000356130

    UniGene: Hs.6874



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