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  4. Recombinant Human Disks large homolog 3 (DLG3), partial

Recombinant Human Disks large homolog 3 (DLG3), partial

  • 中文名稱：
    人DLG3重組蛋白
  • 貨號：
    CSB-YP835698HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DLG3重組蛋白
  • 貨號：
    CSB-EP835698HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DLG3重組蛋白
  • 貨號：
    CSB-EP835698HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DLG3重組蛋白
  • 貨號：
    CSB-BP835698HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DLG3重組蛋白
  • 貨號：
    CSB-MP835698HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    bA291O7.3; bA291O7.3 discs large Drosophila homolog 3 neuroendocrine dlg; Discs large Drosophila homolog 3; Discs large homolog 3 neuroendocrine dlg Drosophila; Discs large homolog 3; Discs large homolog 3 Drosophila; Discs, large homolog 3 (Drosophila); Disks large homolog 3; DLG 3; Dlg3; DLG3_HUMAN; KIAA1232; mKIAA1232; MRX 90; MRX; MRX90; NE Dlg ; NEDLG; Neuroendocrine dlg ; Neuroendocrine-DLG; OTTHUMP00000023475; OTTHUMP00000023476; OTTHUMP00000023477; SAP 102; SAP-102; SAP102; Synapse associated protein 102; Synapse-associated protein 102; XLMR
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

相關(guān)產(chǎn)品

靶點詳情

  • 功能：
    Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
  • 基因功能參考文獻：
    1. This family broadens the mutational and phenotypical spectrum of DLG3-associated non-syndromic X-linked intellectual disability and demonstrates that heterozygous female mutation carriers can be as severely affected as males. PMID: 28777483
    2. Following the critical period NMDA receptor function was unaffected by loss of SAP102 but there was a reduction in the divergence of TC connectivity. These data suggest that changes in synaptic function early in development caused by mutations in SAP102 result in changes in network connectivity later in life. PMID: 27466188
    3. The dupG DLG3 variant segregated with non-syndromic X-linked intellectual disability in a large family and was predicted to disrupt folding of the mRNA. PMID: 27222290
    4. Insertion of a guanine into the DLG3 5' UTR, 7 bp upstream of the start codon, down regulated DLG3 protein levels. This non-coding variant segregates with X-linked intellectual disability in a large family. PMID: 27222290
    5. miR-1246 might play a role in neurological pathogenesis of human enterovirus 71 by regulating DLG3 gene in infected cells. PMID: 24739954
    6. These data shed new light on the role of SAP102 in the regulation of NMDAR trafficking. PMID: 25555912
    7. This study identified DLG3 significantly associated loci with a biologically plausible role in schizophrenia. PMID: 24507884
    8. The data of this study suggested that DLG3 is down-regulated in this cancer type. PMID: 24381070
    9. The PDZ-independent interaction between SAP102 and GluN2B mediates the synaptic clearance of GluN2B-containing NMDARs.(SAP102 protein) PMID: 23103165
    10. Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin. PMID: 22745750
    11. A total of six novel and 11 known single nucleotide polymorphisms were identified. Further studies are warranted to analyze the candidate genes at Xq11.1-q21.33. PMID: 21384559
    12. DLG3 was identified by genome-wide gene expression analyses as correlated with cellular sensitivity to cisplatin and carboplatin. DLG3 was also found to correlate with cellular sensitivity to platinating agents in NCI-60 cancer cell lines. PMID: 21252287
    13. DLG3 did not associate with non-syndromic mental retardation in Chinese Han population; however, further studies are needed. PMID: 21369957
    14. Results identified a novel splice site mutation in the disc-large homolog 3 (DLG3) gene, encoding the synapse-associated protein 102 (SAP102) in one out of 300 families with moderate to severe non-syndromic mental retardation. PMID: 19795139
    15. Loss may lead to altered synaptic plasticity and may explain the intellectual impairment observed in individuals with DLG3 mutations PMID: 15185169
    16. E6AP is extensively involved in the ubiquitin-mediated degradation of Dlg (an HPV E6-dependent substrate) as a cellular E3 ubiquitin-protein ligase. PMID: 16482544
    17. The results of this study suggested a putative role for DLG3/SAP102 in cortical hyperexcitability and epileptogenicity of malformations of cortical development. PMID: 19167192

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  • 相關(guān)疾病：
    Mental retardation, X-linked 90 (MRX90)
  • 蛋白家族：
    MAGUK family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2902

    OMIM: 300189

    KEGG: hsa:1741

    STRING: 9606.ENSP00000363480

    UniGene: Hs.721586



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