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DLG3 Antibody

  • 中文名稱(chēng):
    DLG3兔多克隆抗體
  • 貨號(hào):
    CSB-PA006937GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    bA291O7.3 antibody; bA291O7.3 discs large Drosophila homolog 3 neuroendocrine dlg antibody; Discs large Drosophila homolog 3 antibody; Discs large homolog 3 neuroendocrine dlg Drosophila antibody; Discs large homolog 3 antibody; Discs large homolog 3 Drosophila antibody; Discs, large homolog 3 (Drosophila) antibody; Disks large homolog 3 antibody; DLG 3 antibody; Dlg3 antibody; DLG3_HUMAN antibody; KIAA1232 antibody; mKIAA1232 antibody; MRX 90 antibody; MRX antibody; MRX90 antibody; NE Dlg antibody; NEDLG antibody; Neuroendocrine dlg antibody; Neuroendocrine-DLG antibody; OTTHUMP00000023475 antibody; OTTHUMP00000023476 antibody; OTTHUMP00000023477 antibody; SAP 102 antibody; SAP-102 antibody; SAP102 antibody; Synapse associated protein 102 antibody; Synapse-associated protein 102 antibody; XLMR antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DLG3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
  • 基因功能參考文獻(xiàn):
    1. This family broadens the mutational and phenotypical spectrum of DLG3-associated non-syndromic X-linked intellectual disability and demonstrates that heterozygous female mutation carriers can be as severely affected as males. PMID: 28777483
    2. Following the critical period NMDA receptor function was unaffected by loss of SAP102 but there was a reduction in the divergence of TC connectivity. These data suggest that changes in synaptic function early in development caused by mutations in SAP102 result in changes in network connectivity later in life. PMID: 27466188
    3. The dupG DLG3 variant segregated with non-syndromic X-linked intellectual disability in a large family and was predicted to disrupt folding of the mRNA. PMID: 27222290
    4. Insertion of a guanine into the DLG3 5' UTR, 7 bp upstream of the start codon, down regulated DLG3 protein levels. This non-coding variant segregates with X-linked intellectual disability in a large family. PMID: 27222290
    5. miR-1246 might play a role in neurological pathogenesis of human enterovirus 71 by regulating DLG3 gene in infected cells. PMID: 24739954
    6. These data shed new light on the role of SAP102 in the regulation of NMDAR trafficking. PMID: 25555912
    7. This study identified DLG3 significantly associated loci with a biologically plausible role in schizophrenia. PMID: 24507884
    8. The data of this study suggested that DLG3 is down-regulated in this cancer type. PMID: 24381070
    9. The PDZ-independent interaction between SAP102 and GluN2B mediates the synaptic clearance of GluN2B-containing NMDARs.(SAP102 protein) PMID: 23103165
    10. Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin. PMID: 22745750
    11. A total of six novel and 11 known single nucleotide polymorphisms were identified. Further studies are warranted to analyze the candidate genes at Xq11.1-q21.33. PMID: 21384559
    12. DLG3 was identified by genome-wide gene expression analyses as correlated with cellular sensitivity to cisplatin and carboplatin. DLG3 was also found to correlate with cellular sensitivity to platinating agents in NCI-60 cancer cell lines. PMID: 21252287
    13. DLG3 did not associate with non-syndromic mental retardation in Chinese Han population; however, further studies are needed. PMID: 21369957
    14. Results identified a novel splice site mutation in the disc-large homolog 3 (DLG3) gene, encoding the synapse-associated protein 102 (SAP102) in one out of 300 families with moderate to severe non-syndromic mental retardation. PMID: 19795139
    15. Loss may lead to altered synaptic plasticity and may explain the intellectual impairment observed in individuals with DLG3 mutations PMID: 15185169
    16. E6AP is extensively involved in the ubiquitin-mediated degradation of Dlg (an HPV E6-dependent substrate) as a cellular E3 ubiquitin-protein ligase. PMID: 16482544
    17. The results of this study suggested a putative role for DLG3/SAP102 in cortical hyperexcitability and epileptogenicity of malformations of cortical development. PMID: 19167192

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  • 相關(guān)疾病:
    Mental retardation, X-linked 90 (MRX90)
  • 蛋白家族:
    MAGUK family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 2902

    OMIM: 300189

    KEGG: hsa:1741

    STRING: 9606.ENSP00000363480

    UniGene: Hs.721586



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