在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Disintegrin and metalloproteinase domain-containing protein 23 (ADAM23), partial

Recombinant Human Disintegrin and metalloproteinase domain-containing protein 23 (ADAM23), partial

  • 中文名稱：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 23(ADAM23),partial
  • 貨號：
    CSB-YP001285HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 23(ADAM23),partial
  • 貨號：
    CSB-EP001285HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 23(ADAM23),partial
  • 貨號：
    CSB-EP001285HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 23(ADAM23),partial
  • 貨號：
    CSB-BP001285HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 23(ADAM23),partial
  • 貨號：
    CSB-MP001285HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ADAM23
  • Uniprot No.：
  • 別名：
    ADAM23; MDC3; Disintegrin and metalloproteinase domain-containing protein 23; ADAM 23; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3; MDC-3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
  • 基因功能參考文獻：
    1. The relationships between the decreased methylation levels of the SNAI2 and ADAM23 genes and cancer de-differentiation and haematogenous dissemination, respectively, indicate novel functions of those genes in the invasive processes. PMID: 30189837
    2. Our results demonstrate that ADAM23 expression is likely involved in the progression of epithelial ovarian cancer PMID: 29921495
    3. ADAM23 regulates neuronal differentiation by triggering specific signaling pathways during human neural progenitor cells differentiation. PMID: 28828010
    4. these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy PMID: 27760137
    5. Our data provide evidence that ADAM23 plays a role in suppression of cancer cell progression through interaction with aVb3 integrin, and suggest that downregulation of ADAM23 in SP cells may contribute toward providing a cancer stem cell phenotype PMID: 26800504
    6. High ADAM23 gene methylation is associated with gastric tumor aggressiveness. PMID: 25740824
    7. quantification of CXCL12 and ADAM23 methylation could be useful for the prediction of advanced stage of BC PMID: 25620615
    8. Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. PMID: 24662834
    9. The expression level of ADAM23 is likely to be involved in the progression of non-small-cell lung carcinoma, and its downregulation is probably correlated with promoter methylation. PMID: 21429053
    10. a SP1 binding site (-202/-190) that binds SP1 at the proximal promoter of human ADAM23 gene was indentified. PMID: 20851106
    11. Together, these results indicate that ADAM23 down-regulation by methylation in brain tumors is a rare event and it may help explain why brain tumor metastases are rarely found elsewhere in the body. PMID: 15862898
    12. ADAM23 is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter methylation. PMID: 16103878
    13. ADAM23 may be down-regulated by aberrant promoter hypermethylation during the progression of colorectal cancer. PMID: 19089928
    14. PrP(C) is a novel molecular partner for ADAM23 in the nervous systems. PMID: 19477226
    15. Functional role of ADAM23 during lung caner metastatic progression by negatively modulating alpha(v)beta(3) integrin activation. PMID: 19549921

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Isoform Gamma]: Secreted.
  • 組織特異性：
    Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
  • 數據庫鏈接：

    HGNC: 202

    OMIM: 603710

    KEGG: hsa:8745

    STRING: 9606.ENSP00000264377

    UniGene: Hs.370287



主站蜘蛛池模板： 色又黄又爽18禁免费网站| 18禁成人网站免费观看| 精品人妻少妇一区二区三区在线 | 欧美丰满熟妇bbb久久久| 疯狂做受xxxx高潮视频免费| 天天躁夜夜踩很很踩2022| 在线观看国产日韩亚洲中| 一边摸一边做爽的免费视频日本| 国产一区二区三区乱码| 国内精品久久久久久中文字幕| 三上悠亚精品一区二区久久 | 处破痛哭a√18成年片免费 | 亚洲国产精品嫩草影院永久 | 国产精品白浆在线观看免费| 国产美女久久精品香蕉| 久久久久久国产精品免费免费| 无码av高潮抽搐流白浆| 国产精品无码日韩欧| 裸体女人高潮毛片| 少妇人妻无码专区视频| 国产精品情侣呻吟对白视频| 人妻三级日本香港三级极| 日本高清无卡码一区二区| 国内精品久久久久影院日本| 成人午夜视频精品一区| 亚洲精品综合一区二区三区在线 | 亚洲а∨精品天堂在线| 伊人www22综合色| 人人做人人爽国产视| 国产美女遭强高潮网站下载| 自拍偷自拍亚洲精品播放| 日韩人妻无码精品无码中文字幕| 亚洲日韩日本中文在线| 欧美xxxx做受视频| 国产激情久久久久久熟女老人av| 精品国产三级a在线观看| 女人被狂躁高潮啊的视频在线看| 亚洲日韩欧洲乱码av夜夜摸| 日韩精品久久久久久久电影蜜臀| 国产在线午夜不卡精品影院| 亚洲熟妇av一区二区三区|