在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ADAM23 Antibody

ADAM23 Antibody

  • 中文名稱：
    ADAM23兔多克隆抗體
  • 貨號：
    CSB-PA001285LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate
      All lanes: ADAM23 antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 92, 93 kDa
      Observed band size: 92 kDa
    • IHC image of CSB-PA001285LA01HU diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA001285LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of 293 cells with CSB-PA001285LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ADAM23 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ADAM23
  • 別名：
    ADAM23; MDC3; Disintegrin and metalloproteinase domain-containing protein 23; ADAM 23; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3; MDC-3
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 23 protein (498-647AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ADAM23 Antibody (CSB-PA001285LA01HU)，的標記方式是Non-conjugated。對于ADAM23 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA001285LB01HU ADAM23 Antibody, HRP conjugated ELISA
    FITC CSB-PA001285LC01HU ADAM23 Antibody, FITC conjugated
    Biotin CSB-PA001285LD01HU ADAM23 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
  • 基因功能參考文獻：
    1. The relationships between the decreased methylation levels of the SNAI2 and ADAM23 genes and cancer de-differentiation and haematogenous dissemination, respectively, indicate novel functions of those genes in the invasive processes. PMID: 30189837
    2. Our results demonstrate that ADAM23 expression is likely involved in the progression of epithelial ovarian cancer PMID: 29921495
    3. ADAM23 regulates neuronal differentiation by triggering specific signaling pathways during human neural progenitor cells differentiation. PMID: 28828010
    4. these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy PMID: 27760137
    5. Our data provide evidence that ADAM23 plays a role in suppression of cancer cell progression through interaction with aVb3 integrin, and suggest that downregulation of ADAM23 in SP cells may contribute toward providing a cancer stem cell phenotype PMID: 26800504
    6. High ADAM23 gene methylation is associated with gastric tumor aggressiveness. PMID: 25740824
    7. quantification of CXCL12 and ADAM23 methylation could be useful for the prediction of advanced stage of BC PMID: 25620615
    8. Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. PMID: 24662834
    9. The expression level of ADAM23 is likely to be involved in the progression of non-small-cell lung carcinoma, and its downregulation is probably correlated with promoter methylation. PMID: 21429053
    10. a SP1 binding site (-202/-190) that binds SP1 at the proximal promoter of human ADAM23 gene was indentified. PMID: 20851106
    11. Together, these results indicate that ADAM23 down-regulation by methylation in brain tumors is a rare event and it may help explain why brain tumor metastases are rarely found elsewhere in the body. PMID: 15862898
    12. ADAM23 is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter methylation. PMID: 16103878
    13. ADAM23 may be down-regulated by aberrant promoter hypermethylation during the progression of colorectal cancer. PMID: 19089928
    14. PrP(C) is a novel molecular partner for ADAM23 in the nervous systems. PMID: 19477226
    15. Functional role of ADAM23 during lung caner metastatic progression by negatively modulating alpha(v)beta(3) integrin activation. PMID: 19549921

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Isoform Gamma]: Secreted.
  • 組織特異性：
    Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
  • 數據庫鏈接：

    HGNC: 202

    OMIM: 603710

    KEGG: hsa:8745

    STRING: 9606.ENSP00000264377

    UniGene: Hs.370287



主站蜘蛛池模板： 久久久橹橹橹久久久久高清| 中年熟妇的大黑p| 国产偷国产偷亚洲清高| 久久亚洲精品成人av二次元| 国精产品48x国精产品| 无码专区久久综合久中文字幕| 婷婷久久综合九色综合88| 99久久er这里只有精品18| 中文字幕免费无码专区| 伊人久久大香线蕉av五月天宝贝| 欧美性生 活18~19| 国产成人综合在线女婷五月99播放 | 无码av最新无码av专区| 色老头精品午夜福利视频| 久久狠狠色噜噜狠狠狠狠97| 中文字幕在线免费看线人| 国产日产欧产精品精品推荐免费| 久久理论片午夜琪琪电影网| 9lporm自拍视频区| 国产精品丝袜黑色高跟鞋| 凹凸国产熟女精品视频| 中文字幕无码热在线视频| 欧美精品色婷婷五月综合| 精品少妇人妻av一区二区三区| 女人爽到喷水的视频大全| 熟妇激情内射com| 亚洲一区二区三区偷拍女厕| 成人网站免费观看| 天天爱天天做久久狠狠做| 手机国产乱子伦精品视频| 一 级做人爱全视频在线看| 18禁黄网站禁片免费观看不卡| 久久精品国产成人午夜福利| 亚洲午夜久久久影院伊人| 麻豆亚洲国产成人精品无码区| 国产精品视频观看裸模| 亚洲 国产 韩国 欧美 在线| 久久国产精品成人影院| 亚洲精品无码久久毛片波多野吉衣 | 人人妻人人澡人人爽国产| 成人免费乱码大片a毛片|