在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Dickkopf-related protein 4 (DKK4)

In Stock
  • 中文名稱:
    人DKK4重組蛋白
  • 貨號:
    CSB-EP883367HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    (Dickkopf-4)(Dkk-4)(hDkk-4)
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    27.2 kDa
  • 表達區域:
    19-224aa
  • 氨基酸序列
    LVLDFNNIRSSADLHGARKGSQCLSDTDCNTRKFCLQPRDEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGTHAEGTTGHPVQENQPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEGQVCSRRGHKDTAQAPEIFQRCDCGPGLLCRSQLTSNRQHARLRVCQKIEKL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 基因功能參考文獻:
    1. Data suggest a critical role of dickkopf 4 (DKK4) in docetaxel resistance of the lung adenocarcinoma A549 (A549/DTX) cells. PMID: 28981599
    2. in NOD/SCID mice supplemented with high glucose, HepG2 xenografted tumors grew rapidly in which elevated levels of beta-catenin, c-Myc and decreased levels of DKK4 were detected. Knockdown of DKK4 by shRNA promotes proliferation of HCC cells in NG, which is suppressed by treating cells exogenously with recombinant DKK4 protein. Our in vitro and in vivo results indicate an important functional role of DKK4 in glucose fa... PMID: 27272409
    3. Our results indicated that DKK4 might be contributed to predicting EOC progression and prognosis. DKK4 could promote the invasion of EOC through JNK activation. PMID: 28666421
    4. We found that TCF7L1 recruits the C-terminal binding protein (CtBP) and histone deacetylase 1 (HDAC1) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1, TCF7L2 and beta-catenin occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 in repressing DKK4 gene expression to promote the oncogenic potential of CRCs. PMID: 28450117
    5. DKK4 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    6. DKK4 may have function on the development and progression of pancreatic cancer. PMID: 26880586
    7. The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR and AA rs3763511of gene DKK4. PMID: 26419038
    8. DKK4 upregulated by T3/TR antagonizes the Wnt signal pathway to suppress tumor cell progression PMID: 23958302
    9. rs3923086 in AXIN2 and rs3763511 in DKK4 that did not show any association in the overall population were significantly associated with early on-set and estrogen receptor negative breast cancers, respectively. PMID: 23516639
    10. It would appear that deregulation of the WNT pathway by overexpression of DKK4 may further impair WNT signaling and lead to Anorectal malformations. PMID: 23108157
    11. Our findings suggest a potential tumour suppressive role of DKK4 as well as that of an important regulator of HCC. PMID: 22249261
    12. Found the unique expression of the Wnt antagonist DKK4 in SW480APC, but not parental SW480 cell-derived exosomes. Upregulation of DKK4 in SW480APC cells was confirmed by RT-PCR, immunoblotting, and immunogold electron microscopy. PMID: 22740476
    13. The TR/DKK4/Wnt/beta-catenin cascade influences the proliferation and migration of hepatoma cells during the metastasis process and support a tumor suppressor role of the thyroid hormone receptor. PMID: 21994129
    14. TFAP2E hypermethylation is associated with clinical nonresponsiveness to chemotherapy in colorectal cancer. Functional assays confirm that TFAP2E-dependent resistance is mediated through DKK4. PMID: 22216841
    15. Polymorphism of DKK4 was significantly associated with brain volume in Chinese individuals. PMID: 21341386
    16. chromosome 8 mapping by FISH PMID: 11701963
    17. DKK4 may play a role in schizophrenia pathogenesis PMID: 17553464
    18. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis. PMID: 18408752
    19. DKK4 is an important negative regulator of colon cancer cell growth. PMID: 19059704
    20. Dickkopf-4 and -2 are significantly upregulated in most colorectal tumors PMID: 19659606

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Dickkopf family
  • 組織特異性:
    Expressed in cerebellum, T-cells, esophagus and lung.
  • 數據庫鏈接:

    HGNC: 2894

    OMIM: 605417

    KEGG: hsa:27121

    STRING: 9606.ENSP00000220812

    UniGene: Hs.159311



主站蜘蛛池模板: 高清国产亚洲欧洲av综合一区| 欧美三级在线播放线观看| 人妻 偷拍 无码 中文字幕| 日本高清无卡码一区二区| 国产偷窥熟女精品视频| 成人小说亚洲一区二区三区| 久久欧美与黑人双交男男| 国产精品卡一卡二卡三| 亚洲人成人伊人成综合网无码| 好硬好湿好爽好深视频| 国产交换配偶在线视频| 男人j桶进女人p无遮挡免费观看| 亚洲第一av网站| 亚洲欧洲成人av每日更新| 人妻av中文字幕一区二区三区| 永久中文字幕免费视频网站 | 国产无遮挡a片无码免费软件| 精品亚洲成a人在线观看| 97精品一区二区视频在线观看 | 人妻无码av中文系列久| 亚洲中文字幕无码中文字| 老熟女毛茸茸浓毛| 日本精品αv中文字幕| 人妻 偷拍 无码 中文字幕| 48沈阳熟女高潮嗷嗷叫| 日韩人妻一区二区三区免费 | 狂野欧美激情性xxxx按摩| 精品久久久无码中文字幕| 久久国产精品-国产精品| 免费无码久久成人影片| 亚洲h成年动漫在线观看网站| 玩弄少妇人妻中文字幕| 久久午夜夜伦鲁鲁片免费无码| 国产精品久久久久久亚洲影视| 国产成人无码av在线播放不卡| 高潮迭起av乳颜射后入| 亚洲日本韩国| 骚虎视频在线观看| 国产人妻久久精品二区三区| 国产成人精品无码a区在线观看 | 久久综合色一综合色88 |