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  4. Human Dickkopf-related protein 4(DKK4) ELISA kit

Human Dickkopf-related protein 4(DKK4) ELISA kit

  • 中文名稱：
    人Dickkopf相關蛋白4(DKK4)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL006923HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人Dickkopf相關蛋白4(DKK4)酶聯(lián)免疫試劑盒（CSB-EL006923HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的DKK4含量。DKK4是一種重要靶點。它在胚胎發(fā)育、組織穩(wěn)態(tài)維持等方面有一定作用。研究發(fā)現(xiàn)，其異常表達與腫瘤發(fā)生發(fā)展等病理過程相關，可能通過參與Wnt信號通路等機制發(fā)揮影響，對它的深入研究有望為相關疾病治療提供新策略。試劑盒檢測范圍為0.625 ng/mL-40 ng/mL，本試劑盒適用于體外實驗環(huán)境下的基礎科研，如癌癥生物學模型驗證、信號通路互作研究或疾病生物標志物探索，支持多類型樣本的同步檢測以滿足不同實驗設計需求，助力研究者深入解析DKK4在疾病調(diào)控網(wǎng)絡中的功能及潛在干預靶點。適用于血清、血漿、組織勻漿及細胞裂解液樣本中DKK4蛋白的精準分析，可用于研究DKK4在腫瘤發(fā)生、干細胞分化或組織再生中的作用。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Dickkopf 4 ELISA Kit; Dickkopf gene 4 ELISA Kit; Dickkopf homolog 4 (Xenopus laevis) ELISA Kit; Dickkopf homolog 4 ELISA Kit; Dickkopf related protein 4 ELISA Kit; Dickkopf-4 ELISA Kit; Dickkopf-related protein 4 short form ELISA Kit; Dickkopf4 ELISA Kit; DKK 4 ELISA Kit; Dkk-4 ELISA Kit; DKK4 ELISA Kit; DKK4_HUMAN ELISA Kit; hDkk 4 ELISA Kit; hDkk-4 ELISA Kit; hDkk4 ELISA Kit; MGC129562 ELISA Kit; MGC129563 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.625 ng/mL-40 ng/mL
  • 靈敏度：
    0.156 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Stem Cells
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 基因功能參考文獻：
    1. Data suggest a critical role of dickkopf 4 (DKK4) in docetaxel resistance of the lung adenocarcinoma A549 (A549/DTX) cells. PMID: 28981599
    2. in NOD/SCID mice supplemented with high glucose, HepG2 xenografted tumors grew rapidly in which elevated levels of beta-catenin, c-Myc and decreased levels of DKK4 were detected. Knockdown of DKK4 by shRNA promotes proliferation of HCC cells in NG, which is suppressed by treating cells exogenously with recombinant DKK4 protein. Our in vitro and in vivo results indicate an important functional role of DKK4 in glucose fa... PMID: 27272409
    3. Our results indicated that DKK4 might be contributed to predicting EOC progression and prognosis. DKK4 could promote the invasion of EOC through JNK activation. PMID: 28666421
    4. We found that TCF7L1 recruits the C-terminal binding protein (CtBP) and histone deacetylase 1 (HDAC1) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1, TCF7L2 and beta-catenin occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 in repressing DKK4 gene expression to promote the oncogenic potential of CRCs. PMID: 28450117
    5. DKK4 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    6. DKK4 may have function on the development and progression of pancreatic cancer. PMID: 26880586
    7. The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR and AA rs3763511of gene DKK4. PMID: 26419038
    8. DKK4 upregulated by T3/TR antagonizes the Wnt signal pathway to suppress tumor cell progression PMID: 23958302
    9. rs3923086 in AXIN2 and rs3763511 in DKK4 that did not show any association in the overall population were significantly associated with early on-set and estrogen receptor negative breast cancers, respectively. PMID: 23516639
    10. It would appear that deregulation of the WNT pathway by overexpression of DKK4 may further impair WNT signaling and lead to Anorectal malformations. PMID: 23108157
    11. Our findings suggest a potential tumour suppressive role of DKK4 as well as that of an important regulator of HCC. PMID: 22249261
    12. Found the unique expression of the Wnt antagonist DKK4 in SW480APC, but not parental SW480 cell-derived exosomes. Upregulation of DKK4 in SW480APC cells was confirmed by RT-PCR, immunoblotting, and immunogold electron microscopy. PMID: 22740476
    13. The TR/DKK4/Wnt/beta-catenin cascade influences the proliferation and migration of hepatoma cells during the metastasis process and support a tumor suppressor role of the thyroid hormone receptor. PMID: 21994129
    14. TFAP2E hypermethylation is associated with clinical nonresponsiveness to chemotherapy in colorectal cancer. Functional assays confirm that TFAP2E-dependent resistance is mediated through DKK4. PMID: 22216841
    15. Polymorphism of DKK4 was significantly associated with brain volume in Chinese individuals. PMID: 21341386
    16. chromosome 8 mapping by FISH PMID: 11701963
    17. DKK4 may play a role in schizophrenia pathogenesis PMID: 17553464
    18. DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis. PMID: 18408752
    19. DKK4 is an important negative regulator of colon cancer cell growth. PMID: 19059704
    20. Dickkopf-4 and -2 are significantly upregulated in most colorectal tumors PMID: 19659606

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Dickkopf family
  • 組織特異性：
    Expressed in cerebellum, T-cells, esophagus and lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2894

    OMIM: 605417

    KEGG: hsa:27121

    STRING: 9606.ENSP00000220812

    UniGene: Hs.159311



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