Recombinant Human Diacylglycerol kinase beta (DGKB), partial

中文名稱：

人DGKB重組蛋白
貨號：

CSB-YP896763HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人DGKB重組蛋白
貨號：

CSB-EP896763HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人DGKB重組蛋白
貨號：

CSB-EP896763HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人DGKB重組蛋白
貨號：

CSB-BP896763HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人DGKB重組蛋白
貨號：

CSB-MP896763HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

DGKB
Uniprot No.：

Q9Y6T7
別名：

90 kDa diacylglycerol kinase; DAG kinase beta; DAGK2; DGK; DGK B; DGK beta; DGK-beta; Dgkb; DGKB_HUMAN; Diacylglycerol kinase beta (90kD); Diacylglycerol kinase beta 90kDa; Diacylglycerol kinase beta; Diglyceride kinase beta; KIAA0718
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol. Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation.; Does not associate with membranes but has a diacylglycerol kinase activity.
基因功能參考文獻(xiàn)：
1. Association with the efficiency of hematopoietic stem cells (HSC) mobilization to PB were found in the SNPs of the DGKB gene involved in cell transport and SDF-1-induced migration ability and of the VCAM1 gene which is essential for HSC homing, suggesting that SNPs involved in cell migration ability might be partly involved in HSC mobilization to peripheral blood. PMID: 27839966
2. in addition to kinase activity, plasma membrane localization via the C1 domain and basic amino acids at the C-terminus were indispensable for neurite induction by DGKbeta PMID: 24695318
3. forced expression of diacylglycerol kinase beta abrogated DAG accumulation at the phagosome, leading to impaired respiratory burst. PMID: 23814057
4. human diacylglycerol kinase beta gene can generate several enzyme isoforms, which can display different expression levels and subcellular localization but similar enzymatic activities in vitro. PMID: 11719522
5. Includes the identification and expression profile of this gene (named as KIAA0718). PMID: 9872452
6. Indicates that this protein can interact with keratin 31 and with protocadherin beta 5. PMID: 17353931
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亞細(xì)胞定位：

Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cytoplasm.; [Isoform 2]: Cytoplasm.
蛋白家族：

Eukaryotic diacylglycerol kinase family
組織特異性：

[Isoform 1]: Specifically expressed in brain but also detected in uterus. In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus.; [Isoform 2]: More ubiquitously expressed but at lower level compared to isoform 1.
數(shù)據(jù)庫鏈接：

HGNC: 2850

OMIM: 604070

KEGG: hsa:1607

STRING: 9606.ENSP00000382260

UniGene: Hs.567255