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  4. Recombinant Human Dermatan-sulfate epimerase (DSE), partial

Recombinant Human Dermatan-sulfate epimerase (DSE), partial

  • 中文名稱：
    人DSE重組蛋白
  • 貨號：
    CSB-YP890925HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DSE重組蛋白
  • 貨號：
    CSB-EP890925HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DSE重組蛋白
  • 貨號：
    CSB-EP890925HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DSE重組蛋白
  • 貨號：
    CSB-BP890925HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DSE重組蛋白
  • 貨號：
    CSB-MP890925HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Chondroitin glucuronate 5 epimerase; Chondroitin-glucuronate 5-epimerase; Dermatan sulfate epimerase; Dermatan-sulfate epimerase; DS epimerase; DSE; DSE_HUMAN; DSEPI; OTTHUMP00000040406; SART 2; SART-2; Squamous cell carcinoma antigen recognized by T cells 2; Squamous cell carcinoma antigen recognized by T-cells 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
  • 基因功能參考文獻：
    1. Study showed that DSE is frequently upregulated in human glioma tissue and cell lines and associated with a worse tumor grade and poor overall survival. Its knockdown suppresses malignant phenotypes, whereas DSE overexpression enhances glioma cell malignancy, both in vitro and in vivo. Mechanically, DSE modulates HB-EGF-induced EGFR/ErbB2 activity and downstream signaling. PMID: 29864158
    2. study identified a homozygous DSE missense mutation (c.803C>T, p.S268L) in a male child with musculocontractural type of Ehlers-Danlos syndrome; data indicate mutation affects the epimerase activity, resulting in reduced dermatan sulfate (DS) biosynthesis and an increased synthesis or an accumulation or reduced conversion of chondroitin sulfate PMID: 23704329
    3. Dermatan sulfate epimerase 1 was highly upregulated in esophagus squamous cell carcinoma PMID: 22350411
    4. Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function. PMID: 19004833
  • 相關疾病：
    Ehlers-Danlos syndrome, musculocontractural type 2 (EDSMC2)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Dermatan-sulfate isomerase family
  • 組織特異性：
    Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Exp
  • 數據庫鏈接：

    HGNC: 21144

    OMIM: 605942

    KEGG: hsa:29940

    STRING: 9606.ENSP00000332151

    UniGene: Hs.458358



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