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  4. DSE Antibody, Biotin conjugated

DSE Antibody, Biotin conjugated

  • 中文名稱：
    DSE兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA890925LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DSE Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Chondroitin glucuronate 5 epimerase antibody; Chondroitin-glucuronate 5-epimerase antibody; Dermatan sulfate epimerase antibody; Dermatan-sulfate epimerase antibody; DS epimerase antibody; DSE antibody; DSE_HUMAN antibody; DSEPI antibody; OTTHUMP00000040406 antibody; SART 2 antibody; SART-2 antibody; Squamous cell carcinoma antigen recognized by T cells 2 antibody; Squamous cell carcinoma antigen recognized by T-cells 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Dermatan-sulfate epimerase protein (23-270AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
  • 基因功能參考文獻：
    1. Study showed that DSE is frequently upregulated in human glioma tissue and cell lines and associated with a worse tumor grade and poor overall survival. Its knockdown suppresses malignant phenotypes, whereas DSE overexpression enhances glioma cell malignancy, both in vitro and in vivo. Mechanically, DSE modulates HB-EGF-induced EGFR/ErbB2 activity and downstream signaling. PMID: 29864158
    2. study identified a homozygous DSE missense mutation (c.803C>T, p.S268L) in a male child with musculocontractural type of Ehlers-Danlos syndrome; data indicate mutation affects the epimerase activity, resulting in reduced dermatan sulfate (DS) biosynthesis and an increased synthesis or an accumulation or reduced conversion of chondroitin sulfate PMID: 23704329
    3. Dermatan sulfate epimerase 1 was highly upregulated in esophagus squamous cell carcinoma PMID: 22350411
    4. Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function. PMID: 19004833
  • 相關疾病：
    Ehlers-Danlos syndrome, musculocontractural type 2 (EDSMC2)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Dermatan-sulfate isomerase family
  • 組織特異性：
    Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Exp
  • 數據庫鏈接：

    HGNC: 21144

    OMIM: 605942

    KEGG: hsa:29940

    STRING: 9606.ENSP00000332151

    UniGene: Hs.458358



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