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  4. Recombinant Human Deleted in lung and esophageal cancer protein 1 (DLEC1), partial

Recombinant Human Deleted in lung and esophageal cancer protein 1 (DLEC1), partial

  • 中文名稱：
    人DLEC1重組蛋白
  • 貨號：
    CSB-YP897520HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DLEC1重組蛋白
  • 貨號：
    CSB-EP897520HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DLEC1重組蛋白
  • 貨號：
    CSB-EP897520HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DLEC1重組蛋白
  • 貨號：
    CSB-BP897520HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DLEC1重組蛋白
  • 貨號：
    CSB-MP897520HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DLEC1
  • Uniprot No.：
  • 別名：
    DLEC1; DLC1Deleted in lung and esophageal cancer protein 1; Deleted in lung cancer protein 1; DLC-1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Essential for spermatogenesis and male fertility. May play an important role in sperm head and tail formation. May act as a tumor suppressor by inhibiting cell proliferation.
  • 基因功能參考文獻：
    1. We found no correlation between the DLEC1, TUSC4 and MLH1 gene expression and NSCLC patient characteristics (gender, age and smoking) or cancer histopathology. No significant differences in the gene expression among NSCLC subtypes indicate the weakness of DLEC1, TUSC4 and MLH1 expression analysis as potential differentiating markers of NSCLC subtypes in the Polish population. PMID: 28674222
    2. the expression levels of DLEC1 and ITGA9 were prominently decreased in lung tumor samples PMID: 27287342
    3. DLEC1 mediates tumor-suppressive activities through NF-kappaB signaling. PMID: 25648635
    4. DLEC1 methylation was not associated with the clinicopathological variables of gastric cancer. PMID: 25574068
    5. DLEC1 is down-regulated in head and neck squamous cell tumors and it's promoter methylation is not associated with the clinicopathological parameters. PMID: 25746324
    6. methylation-mediated silencing of DLEC1 plays an important role in multiple lymphomagenesis, and may serve as a non-invasive tumor marker for lymphoma diagnosis PMID: 23050586
    7. Repression of DLEC1 in squamous cell carcinoma tissues is associated with promoter hypermethylation. DLEC1 is downregulated in sinonasal squamous cell carcinoma and inverted papilloma and has a distinct mechanism. PMID: 22569009
    8. Epigenetic inactivation of DLEC1 was crucial in gastric and colorectal carcinogenesis. DLEC1 methylation in serum may be a promise biomarker for GAC and CRAC early diagnosis. PMID: 21443130
    9. results demonstrate that down-expression and promoter methylation of DLEC1 increased from normal tissues to premalignancies and then to malignancies. PMID: 20952247
    10. Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation is associated with non-small-cell lung cancer. PMID: 20630829
    11. DLEC1 is often down-regulated by CpG methylation and shows tumor inhibitory function in renal cell carcinoma cells, indicating its role as a tumor suppressor PMID: 20639048
    12. DLEC1 expression levels were significantly lower in samples from patients who developed metastasis, local recurrence, or died of breast cancer when compared to those who were disease free for >10 years. PMID: 20530412
    13. DLEC1 suppresses the growth of ovarian cancer cells and its downregulation is closely associated with promoter hypermethylation and histone hypoacetylation PMID: 16756719
    14. Silencing of DLEC1 expression by promoter hypermethylation and histone deacetylation may be important in nasopharyngeal carcinoma tumorigenesis. PMID: 17099870
    15. DLEC1 is a candidate tumor suppressor gene that plays an important role in the development and progression of hepatocellular carcinoma. PMID: 18191269
    16. DLEC1 methylation was an independent marker of poor survival in patients with non-small cell lung carcinoma. PMID: 18594535
    17. DLEC1 underwent promoter methylation-associated silencing in colon and gastric tumour cell lines and primary tumours. PMID: 19156137

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  • 相關疾病：
    Lung cancer (LNCR); Esophageal cancer (ESCR)
  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Expressed in all tissues examined. Expression is highest in prostate and testis.
  • 數據庫鏈接：

    HGNC: 2899

    OMIM: 133239

    KEGG: hsa:9940

    STRING: 9606.ENSP00000308597

    UniGene: Hs.714499



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