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  4. Recombinant Human Dedicator of cytokinesis protein 9 (DOCK9), partial

Recombinant Human Dedicator of cytokinesis protein 9 (DOCK9), partial

  • 中文名稱：
    人DOCK9重組蛋白
  • 貨號：
    CSB-YP880144HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DOCK9重組蛋白
  • 貨號：
    CSB-EP880144HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DOCK9重組蛋白
  • 貨號：
    CSB-EP880144HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DOCK9重組蛋白
  • 貨號：
    CSB-BP880144HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DOCK9重組蛋白
  • 貨號：
    CSB-MP880144HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DOCK9
  • Uniprot No.：
  • 別名：
    Cdc42 guanine nucleotide exchange factor zizimin 1; Cdc42 guanine nucleotide exchange factor zizimin-1; Dedicator of cytokinesis protein 9; DKFZp686C11110; DKFZp686D2047; DKFZp686N04132; DOCK 9; DOCK9; DOCK9_HUMAN; FLJ16744; FLJ44528; FLJ45282; FLJ45601; KIAA1058; KIAA1085; ZIZ1; Zizimin1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.
  • 基因功能參考文獻：
    1. c.2262A>C substitution in DOCK9 leads to a splicing aberration. However, because the mutation effect was observed in vitro, a definitive relationship between DOCK9 and KTCN phenotype could not be established. PMID: 26641546
    2. Studies indicate that that many of the mechanistic principles of the exchange process are conserved in the DOCK9-catalyzed reaction. PMID: 19809089
    3. Sequence comparison combined with mutational analysis identified a new domain, which we named CZH2, that mediates direct interaction with Cdc42 PMID: 12172552
    4. DOCK9 contributes to both risk and increased illness severity in bipolar disorder. PMID: 17728666
    5. novel functions for the N-terminal region of zizimin1. PMID: 17935486
    6. DOCK2 and DOCK9 specifically recognize Rac2 and Cdc42 through their switch 1 as well as beta2-beta3 regions and the mode of recognition via switch 1 appears to be conserved among diverse Rac-specific DHR-2 GEFs PMID: 18056264
    7. interaction between Smad2/3 and the Cdc42 guanine nucleotide exchange factor, Zizimin1, in response to TGF-beta1 PMID: 18729074
    8. through structural analysis of DOCK9-Cdc42 complexes, we identify a nucleotide sensor within the alpha10 helix of the DHR2 domain that contributes to release of guanine diphosphate (GDP) and then to discharge of the activated GTP-bound Cdc42 PMID: 19745154

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  • 亞細胞定位：
    Endomembrane system.
  • 蛋白家族：
    DOCK family
  • 組織特異性：
    Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 14132

    OMIM: 607325

    KEGG: hsa:23348

    STRING: 9606.ENSP00000365643

    UniGene: Hs.596105



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