在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human DNA-directed RNA polymerase I subunit RPA1 (POLR1A), partial

Recombinant Human DNA-directed RNA polymerase I subunit RPA1 (POLR1A), partial

  • 中文名稱：
    人POLR1A重組蛋白
  • 貨號：
    CSB-YP018322HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人POLR1A重組蛋白
  • 貨號：
    CSB-EP018322HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人POLR1A重組蛋白
  • 貨號：
    CSB-EP018322HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人POLR1A重組蛋白
  • 貨號：
    CSB-BP018322HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人POLR1A重組蛋白
  • 貨號：
    CSB-MP018322HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    POLR1A
  • Uniprot No.：
  • 別名：
    A190; AFDCIN; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; DNA-directed RNA polymerase I subunit rpa1; Polr1a; Polymerase (RNA) I polypeptide A 194kDa; RNA polymerase I 194 kDa subunit; RNA polymerase I subunit A; RNA polymerase I subunit A1; RPA1; RPA1_HUMAN; RPA194; RPO1 4; RPO14
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
  • 基因功能參考文獻：
    1. Data show that BRCA1 interacts directly with the basal RNA polymerase I (Pol-I) transcription factors as well as interacting with RNA Pol-I itself. PMID: 27589844
    2. Homozygous c.2801C>T (p.(Ser934Leu)) in POLR1A was identified in two brothers with unusual neurological disease that manifested with ataxia, psychomotor retardation, cerebellar and cerebral atrophy, and leukodystrophy. PMID: 28051070
    3. Consistent with this observation, we discovered that polr1a mutant zebrafish exhibited cranioskeletal anomalies mimicking the human phenotype. polr1a loss of function led to perturbed ribosome biogenesis and p53-dependent cell death PMID: 25913037
    4. SIRT7 knockdown leads to reduced levels of RNA Pol I protein, but not messenger RNA PMID: 22586326
    5. findings demonstrate that Bloom's syndrome helicase (BLM)interacts with RPA194; studies suggest that nucleolar BLM modulates rDNA structures in association with RNA polymerase I to facilitate RNA polymerase I-mediated rRNA transcription PMID: 22106380
    6. Interference of POLR1A inhibited the synthesis of rRNA and hindered cell cycle progression in cells with inactivated p53, as a consequence of downregulation of the transcription factor E2F-1. PMID: 21878508
    7. analyzed the kinetics of assembly and elongation of the RNA polymerase I complex on endogenous ribosomal genes in the nuclei of living cells with the use of in vivo microscopy [RPA43] PMID: 12446911

    顯示更多

    收起更多

  • 相關疾病：
    Acrofacial dysostosis, Cincinnati type (AFDCIN)
  • 亞細胞定位：
    Nucleus, nucleolus. Chromosome.
  • 蛋白家族：
    RNA polymerase beta' chain family
  • 數據庫鏈接：

    HGNC: 17264

    OMIM: 616404

    KEGG: hsa:25885

    STRING: 9606.ENSP00000263857

    UniGene: Hs.531818



主站蜘蛛池模板： 亚洲va欧美va国产va综合| 亚洲欧洲日产国码在线| 夜色约爱网站| 最新无码a∨在线观看| 免费人成在线观看网站| 在线播放亚洲第一字幕| 亚洲欧洲日韩国内高清| 成人无码av网站在线观看 | 少妇愉情理伦片bd| 国产乱人激情h在线观看| 久国产精品人妻aⅴ| 国产精品无码久久综合网| 强行无套内谢大学生初次| 精品国产乱码久久久久久1区2区| 亚洲人成网站在线播放影院在线 | 欧美又大又粗午夜剧场免费| 2018年秋霞无码片| 亚洲一区二区三区含羞草| 国产成人无码免费看片软件| 高清不卡毛片免费观看| 人妻系列无码一区二区三区| 亚洲国产精品自产在线播放| 久久久中文久久久无码| 一本大道久久香蕉成人网| 日本xxxxx片免费观看喷水| av在线播放日韩亚洲欧| 色偷拍 自怕 亚洲 10p| 在线|国产精品女主播阳台| 国产精品久久久久久久久久妞妞 | 成人精品一区日本无码网| 婷婷成人丁香五月综合激情| 久久精品国产男包| 少妇一晚三次一区二区三区| 欧美性生 活18~19| 伦理片午夜视频在线观看| 亚洲国产成人第一天堂| 最近中文字幕在线中文视频| 忘忧草日本在线www| 国产网曝门亚洲综合在线| 精品综合久久久久久888蜜芽| 久久中文字幕人妻丝袜|