在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human DNA cross-link repair 1A protein (DCLRE1A), partial

In Stock
  • 貨號(hào):
    CSB-EP761360HU
  • 規(guī)格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    DCLRE1A
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 來(lái)源:
    E.coli
  • 分子量:
    4.1 kDa
  • 表達(dá)區(qū)域:
    690-1040aa
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem).
  • 基因功能參考文獻(xiàn):
    1. Strikingly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure. The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking reaction. PMID: 28607004
    2. Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A and SNM1B. PMID: 26582912
    3. differences in the substrate selectivities of SNM1A and SNM1B are likely to be relevant to their in vivo roles PMID: 22692201
    4. collaboration between hSNM1A and XPF-ERCC1 is necessary to initiate interstrand cross-link repair in replicating human cells PMID: 21896658
    5. RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger PMID: 20385554
    6. Results suggest that 53BP1 and Snm1 may cooperate in the cellular response to genotoxic damage. PMID: 12446782
    7. Snm1 and 53BP1 are components of a mitotic stress checkpoint that negatively targets the APC prior to chromosome condensation PMID: 15542852
    8. The SNM1 enzyme utilizes either DNA or RNA substrates, requires a 5'-phosphate moiety, shows very little activity on double-strand substrates, and functions at a size consistent with a monomer. PMID: 17804464
    9. Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. PMID: 18006388
    10. hSNM1 appears to represent a second pathway for genome stability PMID: 18180189
    11. These findings suggest that SNM1A acts with ATM to promote the G1 cell cycle checkpoint. PMID: 18848520

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1.
  • 蛋白家族:
    DNA repair metallo-beta-lactamase (DRMBL) family
  • 組織特異性:
    Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 17660

    OMIM: 609682

    KEGG: hsa:9937

    STRING: 9606.ENSP00000355185

    UniGene: Hs.1560



主站蜘蛛池模板: 国产av仑乱内谢| 亚洲gv天堂gv无码男同| 国产熟妇勾子乱视频| 亚洲高清无在码在线电影| 欧美肥老太牲交| 国产精品第一区揄拍无码| 亚洲国产精品无码观看久久| 新国产三级视频在线播放| 国产乱妇无乱码大黄aa片| 男女同房做爰爽免费| 邻居少妇张开腿让我爽了一夜 | 国产一卡二卡四卡无卡免费| 337p日本欧洲亚洲大胆张筱雨 | 国产精品久久久久久无码五月| 国产精品线路一线路二| 特黄特色大片免费播放器图片| 乱熟女高潮一区二区在线| 国产99久久九九精品无码| 国产在线精品一区二区三区直播| 亚洲伊人情人综合网站| 国产一区二区三区不卡在线观看 | 免费大黄网站在线观| 日韩新无码精品毛片| 亚洲精品无码精品mv在线观看| 真人床震高潮全部视频免费 | 国产99视频精品免费视频36| 久久热最新网站获取| 51国产偷自视频区视频| 男女性杂交内射女bbwxz| 成人无码视频在线观看大全| 99这里有精品视频视频| 性饥渴的农村熟妇| 色翁荡熄又大又硬又粗又视频| 亚洲色大成网站www永久麻豆| 动漫成人无码精品一区二区三区| 日韩在线成年视频人网站观看| 抽插丰满内射高潮视频| 24小时日本在线www免费的| 亚洲国产中文曰韩丝袜| 国产全肉乱妇杂乱视频| 成人欧美一区二区三区1314|