在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human DNA cross-link repair 1A protein (DCLRE1A), partial

In Stock
  • 貨號(hào):
    CSB-EP761360HU
  • 規(guī)格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    DCLRE1A
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 來(lái)源:
    E.coli
  • 分子量:
    4.1 kDa
  • 表達(dá)區(qū)域:
    690-1040aa
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem).
  • 基因功能參考文獻(xiàn):
    1. Strikingly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure. The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking reaction. PMID: 28607004
    2. Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A and SNM1B. PMID: 26582912
    3. differences in the substrate selectivities of SNM1A and SNM1B are likely to be relevant to their in vivo roles PMID: 22692201
    4. collaboration between hSNM1A and XPF-ERCC1 is necessary to initiate interstrand cross-link repair in replicating human cells PMID: 21896658
    5. RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger PMID: 20385554
    6. Results suggest that 53BP1 and Snm1 may cooperate in the cellular response to genotoxic damage. PMID: 12446782
    7. Snm1 and 53BP1 are components of a mitotic stress checkpoint that negatively targets the APC prior to chromosome condensation PMID: 15542852
    8. The SNM1 enzyme utilizes either DNA or RNA substrates, requires a 5'-phosphate moiety, shows very little activity on double-strand substrates, and functions at a size consistent with a monomer. PMID: 17804464
    9. Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. PMID: 18006388
    10. hSNM1 appears to represent a second pathway for genome stability PMID: 18180189
    11. These findings suggest that SNM1A acts with ATM to promote the G1 cell cycle checkpoint. PMID: 18848520

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1.
  • 蛋白家族:
    DNA repair metallo-beta-lactamase (DRMBL) family
  • 組織特異性:
    Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 17660

    OMIM: 609682

    KEGG: hsa:9937

    STRING: 9606.ENSP00000355185

    UniGene: Hs.1560



主站蜘蛛池模板: 久久综合九色综合97伊人| 夜夜爽妓女8888视频免费观看| 亚洲欧美中文字幕5发布| 国产在热线精品视频99公交| 深夜国产成人福利在线观看| 亚洲日韩国产精品第一页一区| 免费国精产品—品二品| 免费人成网站在线观看欧美| 久久久国产99久久国产久一| 亚洲国产av一区二区三区四区| 亚洲成av人片一区二区密柚| 亚洲乱码无人区卡1卡2卡3| 亚洲国产成人综合在线不卡| 国产一区日韩二区欧美三区| 欧美大屁股xxxxhd黑色| 日本少妇高潮喷水免费可以看| 成人午夜福利免费体验区| 三个男吃我奶头一边一个视频 | 人妻 丝袜美腿 中文字幕| 国产午夜亚洲精品久久| 亚洲精品无码少妇30p| 国产成a人亚洲精v品无码性色| 香蕉人妻av久久久久天天| 国产日韩未满十八禁止观看| 国产精品厕所| 国产爆乳美女娇喘呻吟| 国产96色在线 | 国| 国产成人午夜精品影院| 婷婷成人综合激情在线视频播放| 国产69久久精品成人看| 人人澡人人澡人人看添av| 欧美群交射精内射颜射潮喷| 欧美人与物videos另类xxxxx | 欧美丰满老熟妇aaaa片| 久久久受www免费人成| 国产成人剧情av麻豆果冻| 欧美性猛交xxxx乱大交| 日本午夜免费福利视频| 少女高清影视在线观看动漫| 国产精品一区二区 尿失禁| 国内露脸中年夫妇交换|