在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human D-2-hydroxyglutarate dehydrogenase, mitochondrial (D2HGDH)

  • 中文名稱:
    Recombinant Human D-2-hydroxyglutarate dehydrogenase, mitochondrial(D2HGDH)
  • 貨號:
    CSB-YP843153HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human D-2-hydroxyglutarate dehydrogenase, mitochondrial(D2HGDH)
  • 貨號:
    CSB-EP843153HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human D-2-hydroxyglutarate dehydrogenase, mitochondrial(D2HGDH)
  • 貨號:
    CSB-BP843153HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human D-2-hydroxyglutarate dehydrogenase, mitochondrial(D2HGDH)
  • 貨號:
    CSB-MP843153HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    D2HGDH
  • Uniprot No.:
  • 別名:
    D2HGDH; D2HGDD-2-hydroxyglutarate dehydrogenase; mitochondrial; EC 1.1.99.-
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    14-521
  • 氨基酸序列
    LRGAPGA AGSWGRPVGP LARRGCCSAP GTPEVPLTRE RYPVRRLPFS TVSKQDLAAF ERIVPGGVVT DPEALQAPNV DWLRTLRGCS KVLLRPRTSE EVSHILRHCH ERNLAVNPQG GNTGMVGGSV PVFDEIILST ARMNRVLSFH SVSGILVCQA GCVLEELSRY VEERDFIMPL DLGAKGSCHI GGNVATNAGG LRFLRYGSLH GTVLGLEVVL ADGTVLDCLT SLRKDNTGYD LKQLFIGSEG TLGIITTVSI LCPPKPRAVN VAFLGCPGFA EVLQTFSTCK GMLGEILSAF EFMDAVCMQL VGRHLHLASP VQESPFYVLI ETSGSNAGHD AEKLGHFLEH ALGSGLVTDG TMATDQRKVK MLWALRERIT EALSRDGYVY KYDLSLPVER LYDIVTDLRA RLGPHAKHVV GYGHLGDGNL HLNVTAEAFS PSLLAALEPH VYEWTAGQQG SVSAEHGVGF RKRDVLGYSK PPGALQLMQQ LKALLDPKGI LNPYKTLPSQ A
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.
  • 基因功能參考文獻:
    1. D2HGDH-GAL3ST2 is more frequently seen in prostate cancer samples, and seems to be enriched in African Americans. PMID: 27322736
    2. D2HGDH elevates alpha-KG levels via IDH2 expression modulation, influencing histone and DNA methylation, and HIF1alpha hydroxylation. D2HGDH mutants found in diffuse large B-cell lymphoma are enzymatically inert. PMID: 26178471
    3. D2HGDH mutation is not associated with glioblastoma. PMID: 21625441
    4. We did not find evidence for mutations in the genes D2HGDH and L2HGDH as an alternative mechanism for raised 2-hydroxyglutarate levels in brain tumours PMID: 20727073
    5. Observational study of gene-disease association. (HuGE Navigator) PMID: 20727073
    6. Two novel pathogenic mutations in D-2-hydroxyglutarate dehydrogenase gene in patient with a mild presentation and asymptomatic siblings with D-2-hydroxyglutaric aciduria with a splice error (IVS4-2A-->G) and a missense mutation (c.1315A-->G;p.Asn439Asp). PMID: 16037974
    7. This enzyme assay will have utility in differentiating patients with 2-hydroxyglutaric aciduria and in assessing the residual activities linked to pathogenic mutations in the D2HGDH gene PMID: 19283509

    顯示更多

    收起更多

  • 相關疾病:
    D-2-hydroxyglutaric aciduria 1 (D2HGA1)
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    FAD-binding oxidoreductase/transferase type 4 family
  • 數據庫鏈接:

    HGNC: 28358

    OMIM: 600721

    KEGG: hsa:728294

    STRING: 9606.ENSP00000315351

    UniGene: Hs.516813



主站蜘蛛池模板: 亚洲中文字幕无码一区在线| 无码人妻一区二区三区免费手机| 99国产精品欧美一区二区三区| 日本乱偷人妻中文字幕在线| 国产农村乱对白刺激视频| 久久久久无码精品国产人妻无码| 亚洲国产中文曰韩丝袜| 国产产品亚洲产品| 人妻少妇中文字幕乱码| www.-级毛片线天内射视视| 午夜国人精品av免费看| 丰满少妇夜夜爽爽高潮水| 成人性做爰aaa片免费| 国产成人欧美综合在线影院| 婷婷六月丁香缴 清| 女人被躁到高潮免费视频软件| 中国免费看的片| 国产色视频一区二区三区| 国产精品久久婷婷六月丁香| 亚洲国产精品av在线播放| 亚洲一区二区三区中文字幕在线| 久久综合伊人77777麻豆| 中国熟妇牲交视频| 香蕉啪视频在线观看视频久| 欧美黑人又粗又大的性格特点| 俄罗斯丰满熟妇hd| 免费观看的av在线播放| 国产男女猛烈视频在线观看| 九九re6热在线视频精品66| 国产乱人对白| 18禁亚洲深夜福利人口| 琪琪午夜理论片福利在线观看| 少妇的肉体在线观看| 韩国精品一区二区三区四区 | 国产女人与公拘交在线播放| 乌克兰性欧美精品高清| 亚洲精品乱码久久久久久v| 久久发布国产伦子伦精品| 国产精品免费观看调教网| 麻豆妓女爽爽一区二区三 | 日本少妇自慰免费完整版|