在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cytochrome b-c1 complex subunit 7 (UQCRB)

  • 中文名稱:
    人UQCRB重組蛋白
  • 貨號:
    CSB-YP025664HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人UQCRB重組蛋白
  • 貨號:
    CSB-EP025664HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人UQCRB重組蛋白
  • 貨號:
    CSB-EP025664HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人UQCRB重組蛋白
  • 貨號:
    CSB-BP025664HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人UQCRB重組蛋白
  • 貨號:
    CSB-MP025664HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    UQCRB; UQBP; Cytochrome b-c1 complex subunit 7; Complex III subunit 7; Complex III subunit VII; QP-C; Ubiquinol-cytochrome c reductase complex 14 kDa protein
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-111
  • 氨基酸序列
    AGKQAVSAS GKWLDGIRKW YYNAAGFNKL GLMRDDTIYE DEDVKEAIRR LPENLYNDRM FRIKRALDLN LKHQILPKEQ WTKYEEENFY LEPYLKEVIR ERKEREEWAK K
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
  • 基因功能參考文獻:
    1. Our results provide novel insights into the critical role of UQCRB in regulating CRC, supporting UQCRB as a new candidate for the development of diagnostics for CRC patients. PMID: 29147009
    2. The knockdown of UQCRB gene by UQCRB siRNA significantly inhibited the cancer stem cell-like phenotypes as well as the expression of stemness markers by blocking mitochondrial ROS/HIF1alpha/cMet pathway in U87MG GSCs. PMID: 29115404
    3. UQCRB gene mutation is associated with mitochondrial complex III deficiency in a Chinese family. PMID: 28604960
    4. a UQCRB mutation promotes angiogenesis through the generation of mitochondrial reactive oxygen species PMID: 25446085
    5. Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells. PMID: 23708980
    6. Studies indicate that mitochondrial oxygen sensor ubiquinol-cytochrome c reductase binding protein (UQCRB) as a terpestacin-binding protein. PMID: 23475074
    7. Two SNPs in the 3' untranslated region of UQCRB (complex III), rs7836698 and rs10504961, were associated with overall survival. PMID: 22545919

    顯示更多

    收起更多

  • 相關疾病:
    Mitochondrial complex III deficiency, nuclear 3 (MC3DN3)
  • 亞細胞定位:
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族:
    UQCRB/QCR7 family
  • 數據庫鏈接:

    HGNC: 12582

    OMIM: 191330

    KEGG: hsa:7381

    STRING: 9606.ENSP00000287022

    UniGene: Hs.131255



主站蜘蛛池模板: 国产无遮挡又黄又爽不要vip软件| 久久天天躁狠狠躁夜夜av浪潮| 色综合亚洲一区二区小说| 成人无码视频免费播放| 无码国产精品一区二区免费模式| 77777亚洲午夜久久多人| 女人爽到喷水的视频大全| 国产精品国产三级国av在线观看| 怡红院av亚洲一区二区三区h| 一本一道波多野结衣av一区| 国产蝌蚪视频一区二区三区| 国产成人无码精品久久涩吧| 日本黄网站免费| 一本一道波多野结衣av黑人 | 少妇极品熟妇人妻200片| 人人妻人人澡人人爽欧美一区双| 无码人妻精品一区二区蜜桃网站 | 久久久噜噜噜久久熟女| 女厕厕露p撒尿八个少妇| 色吊丝av中文字幕| 国产亚洲综合网曝门系列 | 国产精品ⅴ无码大片在线看| 国产三级不卡在线观看视频| 99热国产这里只有精品6| 伊人久久大香线蕉亚洲五月天| 在线观看无码不卡av| 日本两人免费观看的视频| 精品国产午夜福利精品推荐| 成人国产片女人爽到高潮| 久久久久久久女国产乱让韩 | 夜夜躁日日躁狠狠久久av| 精品无码av无码专区| a级大胆欧美人体大胆666| av无码免费一区二区三区| 国产综合在线观看| 国产美女a做受大片观看| 亚洲 熟女 久久 国产| 国产丰满麻豆videossexhd| 免费精品国偷自产在线在线 | 国产午夜福利片| 久久综合色_综合色88|