在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cyclin-K (CCNK)

  • 中文名稱:
    Recombinant Human Cyclin-K(CCNK)
  • 貨號:
    CSB-YP004828HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Cyclin-K(CCNK)
  • 貨號:
    CSB-EP004828HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Cyclin-K(CCNK)
  • 貨號:
    CSB-EP004828HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Cyclin-K(CCNK)
  • 貨號:
    CSB-MP004828HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    CCNK
  • Uniprot No.:
  • 別名:
    CCNK; CCNK_HUMAN; CPR 4; CPR4; Cyclin K; Cyclin-K; CyclinK; MGC9113
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-580
  • 氨基酸序列
    MKENKENSSP SVTSANLDHT KPCWYWDKKD LAHTPSQLEG LDPATEARYR REGARFIFDV GTRLGLHYDT LATGIIYFHR FYMFHSFKQF PRYVTGACCL FLAGKVEETP KKCKDIIKTA RSLLNDVQFG QFGDDPKEEV MVLERILLQT IKFDLQVEHP YQFLLKYAKQ LKGDKNKIQK LVQMAWTFVN DSLCTTLSLQ WEPEIIAVAV MYLAGRLCKF EIQEWTSKPM YRRWWEQFVQ DVPVDVLEDI CHQILDLYSQ GKQQMPHHTP HQLQQPPSLQ PTPQVPQVQQ SQPSQSSEPS QPQQKDPQQP AQQQQPAQQP KKPSPQPSSP RQVKRAVVVS PKEENKAAEP PPPKIPKIET THPPLPPAHP PPDRKPPLAA ALGEAEPPGP VDATDLPKVQ IPPPAHPAPV HQPPPLPHRP PPPPPSSYMT GMSTTSSYMS GEGYQSLQSM MKTEGPSYGA LPPAYGPPAH LPYHPHVYPP NPPPPPVPPP PASFPPPAIP PPTPGYPPPP PTYNPNFPPP PPRLPPTHAV PPHPPPGLGL PPASYPPPAV PPGGQPPVPP PIPPPGMPPV GGLGRAAWMR
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
  • 基因功能參考文獻:
    1. Cyclin K expression positively correlates with cell proliferation; knockdown of cyclin K or its cognate kinase CDK12 prevents the assembly of prereplicative complex in the G1 cell cycle phase. PMID: 29760377
    2. Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation PMID: 29760377
    3. Structures of CDK12/CycK complexes solved in the presence of AMP-PNP. PMID: 26597175
    4. Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12)/cyclin K (CycK) complex, rendering the kinase inactive. PMID: 25712099
    5. that cyclin K may be a novel molecular link between germ cell development, cancer development and embryonic stem cell maintenance. PMID: 25004108
    6. Cyclin K is highly expressed in mammalian testes in a developmentally regulated manner. PMID: 25004108
    7. Cyclin K interacts with CDK12 and CDK13 but not CDK9 in cells, and is required to maintain self-renewal in ES cells. PMID: 22547058
    8. Cyclin K1 is the primary cyclin partner for CDK12/CrkRS and it is required for activation of CDK12/CrkRS to phosphorylate the C-terminal domain of RNA Pol II. PMID: 22988298
    9. Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner. PMID: 21555514
    10. These results reveal an unexpectedly direct role for CDK9-cyclin K in checkpoint pathways that maintain genome integrity in response to replication stress. PMID: 20930849
    11. Cyclin K-expressing multiple myeloma LP-1 cells have lost their migration properties and display enhanced clonogenic capacities PMID: 20459741
    12. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. PMID: 11884399
    13. cyclin K may play a role in regulating the cell cycle or apoptosis PMID: 11988847
    14. The cyclin K fold comprises two typical cyclin boxes with two short helices preceding the N-terminal box. A prominent feature of cyclin K is an additional helix (H4a) in the first cyclin box that obstructs the binding pocket for the p27. PMID: 17169370

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Cyclin family, Cyclin C subfamily
  • 組織特異性:
    Widely expressed. Highest levels in testis.
  • 數據庫鏈接:

    HGNC: 1596

    OMIM: 603544

    KEGG: hsa:8812

    STRING: 9606.ENSP00000374529

    UniGene: Hs.510409



主站蜘蛛池模板: 国产精品一区二区在线观看| 男女又色又爽又爽视频| 欧美一区二区三区激情| 国产a国产片国产| 亚洲欧美日韩二三区在线| 97久章草在线视频播放| 奇米777四色成人影视| 伊人久久大香线蕉成人| 无码少妇一区二区性色av| 97精品国产一区二区三区| 免费无码av片在线观看播放| 免费人成视频在线观看视频| 国产成人影院一区二区三区| 中日精品无码一本二本三本 | 久久久久成人精品| 国产成人无码免费看片软件| 337人体做爰大胆视频| 超碰cao已满18进入离开官网| 国产精品亚洲综合色区| 97夜夜澡人人爽人人| 亚洲熟女少妇一区二区| 久久99成人免费| 亚洲国产一区二区波多野结衣| 成人亚洲欧美久久久久| 国产精品亚洲a∨天堂| 日本乱偷人妻中文字幕| 美女裸体自慰在线观看| 色老头av亚洲一区二区男男 | 亚洲精品亚洲人成在线下载| 欧美日韩在线亚洲综合国产人| 荡女精品导航| 国产爆乳无码av在线播放| 亚洲精品久久国产高清小说 | 婷婷综合久久中文字幕蜜桃三电影| 久久亚洲精品无码gv| 国产婷婷综合在线视频| 日本人妻巨大乳挤奶水| 免费无码av一区二区| 偷窥村妇洗澡毛毛多| 99国产欧美另娄久久久精品| 国产午夜视频在线观看|