在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cyclic nucleotide-gated cation channel beta-1 (CNGB1), partial

In Stock
  • 中文名稱:
    Recombinant Human Cyclic nucleotide-gated cation channel beta-1 (CNGB1), partial
  • 貨號:
    CSB-EP623897HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Cyclic nucleotide-gated cation channel 4;CNG channel 4;CNG-4;CNG4;Cyclic nucleotide-gated cation channel gamma;Cyclic nucleotide-gated cation channel modulatory subunit;Cyclic nucleotide-gated channel beta-1;CNG channel beta-1;Glutamic acid-rich protein;GARP
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    17
  • 表達區域:
    1084-1178aa
  • 氨基酸序列
    LRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.; Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.
  • 基因功能參考文獻:
    1. Here, we present the first case of RP45 caused by an unequivocal homozygous nonsense variant of CNGB1 identified by run of homozygosity (ROH) analysis. PMID: 26901671
    2. Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP, and FoxP3+Helios+ Tregs have more suppressive characteristics, compared with FoxP3+Helios- Tregs. PMID: 26343373
    3. GARP2 expression in cones can be detrimental to cones. RDS/GARP interactions remain under investigation but are critical for both OS structure and function. PMID: 26720471
    4. The p.Arg86Gln mutation actually appears to be a polymorphism common in ethnic West Africans and not associated with RP. This change may provide a useful marker for West African ancestry. PMID: 23201897
    5. Deletion of the cyclic nucleotide gated channel CNGB1 alters response waveform but leaves light adaptation intact in a transgenic model. PMID: 21123569
    6. When expressed in a heterologous expression system the corresponding mutant full-length CNGB1a subunit was more susceptible to proteosomal degradation compared to the wild-type counterpart PMID: 20126465
    7. we report targeting of cyclic nucleotide-gated channel(CNG) to rod outer segment required interaction with ankyrin-G; ankyrin-G localized to rod outer segments, coimmunoprecipitated with CNG channel & bound to C-terminal domain of channel beta1 subunit PMID: 19299621

    顯示更多

    收起更多

  • 相關疾病:
    Retinitis pigmentosa 45 (RP45)
  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGB1 subfamily
  • 數據庫鏈接:

    HGNC: 2151

    OMIM: 600724

    KEGG: hsa:1258

    STRING: 9606.ENSP00000251102

    UniGene: Hs.147062



主站蜘蛛池模板: 国产嘿嘿嘿视频在线观看| 五月婷婷开心中文字幕| 99久久99久久精品国产片果冻| 日本大片免a费观看视频三区| 国产+日韩+另类+视频一区| 狠狠躁夜夜躁无码中文字幕| 亚洲一区二区三区高清在线看| 亚洲人成色77777在线观看大战p| 国产精品久久久久久亚洲毛片 | 国产97在线 | 免费| 麻豆精产一二三产区| 人妻少妇精品无码专区芭乐视网| 天天爱天天做久久狼狼| 综合五月激情二区视频| 欧美黑人巨大xxxxx| 精品国产乱码久久久久夜深人妻 | 色噜噜亚洲男人的天堂| 久久久www成人免费看片| 色欲天天婬色婬香综合网| 中国少妇内射xxxx狠干| 国内精品人妻无码久久久影院| 在线亚洲日产一区二区| 激情无码人妻又粗又大中国人| 久久亚洲精品中文字幕无码| 亚洲 精品 综合 精品 自拍| 国内揄拍国内精品对白86| 男女性爽大片视频免费看| 天堂中文官网在线| 九九久久精品无码专区| 少妇性l交大片7724com| 青青青国产在线观看资源| 成人免费午夜无码视频| 亚洲精品无amm毛片| 亚洲精品一区二区三区婷婷月 | 日韩国产成人无码av毛片蜜柚| 疯狂的欧美乱大交| 无遮挡国产高潮视频免费观看| 精品国产一区二区三区久久狼 | 国产伦人人人人人人性| 一边捏奶一边高潮视频| 久久婷婷五月综合色中文字幕|