在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cyclic nucleotide-gated cation channel beta-1 (CNGB1), partial

In Stock
  • 中文名稱:
    Recombinant Human Cyclic nucleotide-gated cation channel beta-1 (CNGB1), partial
  • 貨號:
    CSB-EP623897HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Cyclic nucleotide-gated cation channel 4;CNG channel 4;CNG-4;CNG4;Cyclic nucleotide-gated cation channel gamma;Cyclic nucleotide-gated cation channel modulatory subunit;Cyclic nucleotide-gated channel beta-1;CNG channel beta-1;Glutamic acid-rich protein;GARP
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    17
  • 表達區域:
    1084-1178aa
  • 氨基酸序列
    LRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.; Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.
  • 基因功能參考文獻:
    1. Here, we present the first case of RP45 caused by an unequivocal homozygous nonsense variant of CNGB1 identified by run of homozygosity (ROH) analysis. PMID: 26901671
    2. Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP, and FoxP3+Helios+ Tregs have more suppressive characteristics, compared with FoxP3+Helios- Tregs. PMID: 26343373
    3. GARP2 expression in cones can be detrimental to cones. RDS/GARP interactions remain under investigation but are critical for both OS structure and function. PMID: 26720471
    4. The p.Arg86Gln mutation actually appears to be a polymorphism common in ethnic West Africans and not associated with RP. This change may provide a useful marker for West African ancestry. PMID: 23201897
    5. Deletion of the cyclic nucleotide gated channel CNGB1 alters response waveform but leaves light adaptation intact in a transgenic model. PMID: 21123569
    6. When expressed in a heterologous expression system the corresponding mutant full-length CNGB1a subunit was more susceptible to proteosomal degradation compared to the wild-type counterpart PMID: 20126465
    7. we report targeting of cyclic nucleotide-gated channel(CNG) to rod outer segment required interaction with ankyrin-G; ankyrin-G localized to rod outer segments, coimmunoprecipitated with CNG channel & bound to C-terminal domain of channel beta1 subunit PMID: 19299621

    顯示更多

    收起更多

  • 相關疾病:
    Retinitis pigmentosa 45 (RP45)
  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGB1 subfamily
  • 數據庫鏈接:

    HGNC: 2151

    OMIM: 600724

    KEGG: hsa:1258

    STRING: 9606.ENSP00000251102

    UniGene: Hs.147062



主站蜘蛛池模板: 国产伦子系列沙发午睡| 亚洲美女又黄又爽在线观看| 色翁荡熄又大又硬又粗又视频| 五十路熟妇亲子交尾| 亚洲精品无码久久毛片波多野吉衣| 夜夜揉揉日日人人| 国产亚洲精品精品精品| 欧美性猛交xxxx黑人| 国产av亚洲精品ai换脸电影| 久久麻豆成人精品av| 最新精品香蕉在线| 国产成人综合久久精品推下载| 狠狠色丁香五月综合缴情婷婷五月| 中文字字幕在线成人av电影| 国产午夜亚洲精品不卡在线观看| 欧美激欧美啪啪片免费看| 成人女人黄网站免费视频| 内射合集对白在线| 国模叶桐尿喷337p人体| 久久无码潮喷a片无码高潮| 风韵丰满熟妇啪啪区老老熟女百度| 国产免费拔擦拔擦8x高清在线人 | 毛片内射-百度| 疯狂撞击丝袜人妻| 久久综合伊人九色综合| 亚洲中国最大av网站| 久久久噜噜噜久久| 国产又猛又黄又爽| 最近高清中文在线字幕在线观看1| 欧美18videosex性欧美黑吊| 无遮无挡爽爽免费毛片| 真人做人60分钟啪啪免费看| 婷婷丁香六月激情综合啪 | 熟妇高潮一区二区三区| 日韩va中文字幕无码电影| 亚洲精品日本一区二区三区| 久久996re热这里有精品| 久久久久国产精品无码免费看 | 又湿又紧又大又爽又a视频| 亚洲愉拍自拍另类天堂| 中文字幕无线码一区2020青青|