在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cyclic AMP-responsive element-binding protein 3 (CREB3), partial

  • 中文名稱:
    Recombinant Human Cyclic AMP-responsive element-binding protein 3(CREB3),partial
  • 貨號:
    CSB-YP005948HU1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Cyclic AMP-responsive element-binding protein 3(CREB3),partial
  • 貨號:
    CSB-EP005948HU1
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Cyclic AMP-responsive element-binding protein 3(CREB3),partial
  • 貨號:
    CSB-EP005948HU1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Cyclic AMP-responsive element-binding protein 3(CREB3),partial
  • 貨號:
    CSB-BP005948HU1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Cyclic AMP-responsive element-binding protein 3(CREB3),partial
  • 貨號:
    CSB-MP005948HU1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    CREB3; LZIP; Cyclic AMP-responsive element-binding protein 3; CREB-3; cAMP-responsive element-binding protein 3; Leucine zipper protein; Luman; Transcription factor LZIP-alpha
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription. Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death. Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Associates with chromatin to the HERPUD1 promoter. Also induces transcriptional activation of chemokine receptors.; This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGTFunctions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells.; (Microbial infection) Plays a role in human immunodeficiency virus type 1 (HIV-1) virus protein expression.; (Microbial infection) Plays a role in herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestering host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection.; (Microbial infection) May play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HCV) core protein.; (Microbial infection) Activates transcription of genes required for reactivation of the latent HSV-1 virus. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16. Binds DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT(Microbial infection) It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator HCV core protein.
  • 基因功能參考文獻(xiàn):
    1. Luman, a ubiquitous, non-canonical unfolded protein response (UPR), is identified as a novel regulator of endoplasmic reticulum stress-induced PRNP expression. PMID: 28205568
    2. In summary, the authors show here that hepatitis C virus infection is associated with an upregulation of ARF4, which promotes hepatitis C virus replication. Upon hepatitis C virus infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. PMID: 28840565
    3. sLZIP is a novel co-repressor of ERalpha, and plays a negative role in ERalpha-mediated cell proliferation in breast cancer PMID: 28662179
    4. These findings indicate that LZIP is a novel modulator of APOA4 expression and hepatic lipid metabolism. PMID: 28246167
    5. The authors found that the CREB3/Herp pathway limited the increase in cytosolic Ca2+ concentration and apoptosis early in poliovirus infection and this may reduce the extent of poliovirus-induced damage to the central nervous system during poliomyelitis. PMID: 27405867
    6. The essential parts of the Golgi stress response from the perspective of the organelle autoregulation. The pathways of the mammalian Golgi stress response have been identified, specifically the CREB3 pathway. PMID: 28179603
    7. These results indicate that sLZIP plays a role in expression of c-Jun, and migration and invasion of cervical cancer cells via regulation of MMP-9 transcription. PMID: 24481121
    8. INHA gene expression is upregulated by cAMP via CRE in human trophoblasts, and TFAP2 regulates this expression by interacting with CRE. PMID: 25358080
    9. Findings indicate that sLZIP negatively regulates AR transactivation in androgen-dependent PCa cells and functions as a positive regulator in tumor progression of androgen-independent PCa. sLZIP contributes to the malignant phenotype of PCa. PMID: 24441043
    10. human sLZIP plays a critical role in development of atherosclerosis and can be used as a therapeutic target molecule for treatment of atherosclerosis PMID: 25077563
    11. A CREB3-ARF4 signalling cascade may be part of a Golgi stress response set in motion by stimuli compromising Golgi capacity. PMID: 24185178
    12. propose that JAB1 is a novel binding partner of Luman, which negatively regulates the activity of Luman by promoting its degradation PMID: 23583719
    13. GSK3beta was downregulate in all samples and CREB3 did not show a significant decrease or increase in its mRNA expression, but the results were significant in mucoepidermoid carcinoma and salivary duct carcinoma. PMID: 23023215
    14. sLZIP plays a critical role in MMP-9 expression and is probably involved in invasion and metastasis of cervical cancer PMID: 22009750
    15. sLZIP-regulated ARF4 expression in response to phorbol 12-myristate 13-acetate is involved in breast cancer cell migration. PMID: 22004728
    16. These findings suggest that HDAC3 selectively represses CREB3-mediated transcriptional activation and chemotactic signalling in human metastatic breast cancer cells. PMID: 20473547
    17. DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation. PMID: 20546900
    18. sLZIP functions as a negative regulator in glucocorticoid-induced transcriptional activation of GR by recruitment and activation of HDACs PMID: 19779205
    19. Data show that Luman is processed by regulated intramembrane proteolysis. The site 1 protease (S1P), a Golgi-resident enzyme, may be involved in the processing of Luman. PMID: 12138176
    20. HCF-1 contains an activation domain (HCF-1(AD)) required for maximal transactivation by VP16 and its cellular counterpart LZIP. PMID: 12271126
    21. LZIP binds to CCR1 and the interaction between CCR1 and LZIP participates in regulation of Lkn-1-dependent cell migration without affecting the chemotactic activities of other CC chemokines that bind to CCR1. PMID: 15001559
    22. the host cell factor-binding transcription factor Luman is inhibited by Zhangfei PMID: 15705566
    23. Results report the identification of Herp, a gene involved in ER stress-associated protein degradation (ERAD), as a direct target of Luman. PMID: 16940180
    24. LZIP functions as a positive regulator in the NF-kappaB activation pathway that is triggered by Lkn-1 without affecting the transcriptional activation of NF-kappaB induced by other CCR1-dependent chemokines PMID: 17192849
    25. factor NF-kappaB plays an important role in regulation of LZIP expression, and LZIP expression regulates the monocyte cell migration induced by Lkn-1 PMID: 17296613
    26. Luman/CREB3 recruitment factor inhibits Luman activation of the unfolded protein response PMID: 18391022

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Isoform 1]: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus.; [Isoform 2]: Nucleus. Cytoplasm.; [Processed cyclic AMP-responsive element-binding protein 3]: Nucleus.; [Isoform 1]: Cytoplasm.
  • 蛋白家族:
    BZIP family, ATF subfamily
  • 組織特異性:
    Ubiquitously expressed. Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2347

    OMIM: 606443

    KEGG: hsa:10488

    UniGene: Hs.522110



主站蜘蛛池模板: 窝窝午夜色视频国产精品破| 欧美亚洲另类自拍丝袜| 国产av无码专区亚汌a√| 国产精品久久久久9999爆乳| 少妇做爰免费视看片| 挺进邻居丰满少妇的身体| 在线观看国产丝袜控网站| 美女内射毛片在线看3d| 午夜寂寞少妇aaa片毛片| 国产精品自在自线视频| 日韩在线看片免费人成视频播放| 成在线人av免费无码高潮喷水| 亚洲日韩精品a∨片无码加勒比| 欧美性色黄大片www喷水| 国产成人无码激情视频| 中文字幕在线播放| 日本高清视频www夜色资源| 亚洲一区二区制服在线| 伊人久久精品无码麻豆一区| 国产成人av一区二区三区| 久久久国产精华液| 免费做a爰片久久毛片a片下载| 亚洲精品成人av在线| 国产肥白大熟妇bbbb| 爱色精品视频一区二区| 色欲综合久久中文字幕网| 国内a∨免费播放| 久久无码av中文出轨人妻| 邻居少妇张开腿让我爽了一夜| 97久久草草超级碰碰碰| 老熟女重囗味hdxx69| 色8激情欧美成人久久综合电影| 精品多人p群无码| 中文无码av一区二区三区| 永久免费观看美女裸体的网站| 欧美激性欧美激情在线| 欧美熟妇色ⅹxxx欧美妇| 尤物视频在线观看| 欧美综合自拍亚洲图久青草| 亚洲精品中文字幕| 春色校园综合人妻av|