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  4. Recombinant Human Cullin-associated NEDD8-dissociated protein 1 (CAND1), partial

Recombinant Human Cullin-associated NEDD8-dissociated protein 1 (CAND1), partial

  • 中文名稱：
    Recombinant Human Cullin-associated NEDD8-dissociated protein 1(CAND1) ,partial
  • 貨號：
    CSB-YP774815HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cullin-associated NEDD8-dissociated protein 1(CAND1) ,partial
  • 貨號：
    CSB-EP774815HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cullin-associated NEDD8-dissociated protein 1(CAND1) ,partial
  • 貨號：
    CSB-EP774815HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cullin-associated NEDD8-dissociated protein 1(CAND1) ,partial
  • 貨號：
    CSB-BP774815HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cullin-associated NEDD8-dissociated protein 1(CAND1) ,partial
  • 貨號：
    CSB-MP774815HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CAND1
  • Uniprot No.：
  • 別名：
    CAND 1; Cand1; CAND1_HUMAN; Cullin associated and neddylation dissociated 1; Cullin associated and neddylation dissociated protein 1; Cullin associated NEDD8 dissociated protein 1; Cullin-associated and neddylation-dissociated protein 1; Cullin-associated NEDD8-dissociated protein 1; DKFZP434M1414; FLJ10114; FLJ10929; FLJ38691; FLJ90441; KIAA0829; p120 CAND1; TATA binding protein interacting protein 120A; TBP interacting protein; TBP interacting protein of 120 kDa A; TBP Interacting Protein TIP120A; TBP-interacting protein 120A; TBP-interacting protein of 120 kDa A; TIP120; TIP120 protein; TIP120A
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
  • 基因功能參考文獻：
    1. miR-33a and CAND1 played an important role in lung cancer proliferation and cell migration PMID: 28871425
    2. describe the identification of the structural determinants responsible for the CA IX/CAND1 interaction PMID: 28388044
    3. Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1), COP9 signalosome (CSN), neddylated cullin 3 (Cul3) and the BTB protein Keap1. PMID: 26219975
    4. The Epstein-Barr virus protein BPLF1, is targeted to cullin-RING ubiquitin ligases (CRLs) via the interaction of the conserved helix-2 with helix-23 of cullins, at a site involved in electrostatic interaction with CAND1. PMID: 22474075
    5. We demonstrate that the accumulation of p27 is associated with an increase of CAND1 and a decrease of Skp2 during adipogenesis of human LiSa-2 preadipocytes. CAND1 knockdown reduces p27 and blocks adipogenesis. PMID: 23328082
    6. Study shows that Cand1 can unambiguously stimulate SCF activity in vitro by enabling an F box protein-Skp1 complex to access Cul1 that was previously occupied by a different F box protein-Skp1 complex, and that Cand1 promotes assembly in vivo of new F box proteins with pre-existing Cul1 molecules. PMID: 23453757
    7. CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer. PMID: 23019411
    8. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. PMID: 21778237
    9. CAND1 does not function by sequestering cullins in vivo to prevent substrate receptor autoubiquitination and is likely to regulate cullin RING ligase activity via alternative mechanisms PMID: 21249194
    10. miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression. PMID: 20820187
    11. selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation PMID: 12504025
    12. binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex PMID: 12504026
    13. TIP120A functions as a negative regulator of SCF E3 ubiquitin ligases and may modulate other cullin ligases in a similar fashion. PMID: 12609982
    14. CAND1 & COP9 signalosome (CSN), major deneddylase of cullins, bind to unneddylated CUL1 in mutually exclusive way. Suppression of CAND1 expression by siRNA enhanced interaction between CUL1 & CSN, suggesting that CAND1 inhibited binding of CSN to CUL1. PMID: 16036220

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
  • 蛋白家族：
    CAND family
  • 數據庫鏈接：

    HGNC: 30688

    OMIM: 607727

    KEGG: hsa:55832

    STRING: 9606.ENSP00000299218

    UniGene: Hs.546407



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