在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Cullin-associated NEDD8-dissociated protein 1 (CAND1), partial

Recombinant Human Cullin-associated NEDD8-dissociated protein 1 (CAND1), partial

  • 中文名稱：
    Recombinant Human Cullin-associated NEDD8-dissociated protein 1(CAND1) ,partial
  • 貨號：
    CSB-YP774815HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cullin-associated NEDD8-dissociated protein 1(CAND1) ,partial
  • 貨號：
    CSB-EP774815HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cullin-associated NEDD8-dissociated protein 1(CAND1) ,partial
  • 貨號：
    CSB-EP774815HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cullin-associated NEDD8-dissociated protein 1(CAND1) ,partial
  • 貨號：
    CSB-BP774815HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cullin-associated NEDD8-dissociated protein 1(CAND1) ,partial
  • 貨號：
    CSB-MP774815HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CAND1
  • Uniprot No.：
  • 別名：
    CAND 1; Cand1; CAND1_HUMAN; Cullin associated and neddylation dissociated 1; Cullin associated and neddylation dissociated protein 1; Cullin associated NEDD8 dissociated protein 1; Cullin-associated and neddylation-dissociated protein 1; Cullin-associated NEDD8-dissociated protein 1; DKFZP434M1414; FLJ10114; FLJ10929; FLJ38691; FLJ90441; KIAA0829; p120 CAND1; TATA binding protein interacting protein 120A; TBP interacting protein; TBP interacting protein of 120 kDa A; TBP Interacting Protein TIP120A; TBP-interacting protein 120A; TBP-interacting protein of 120 kDa A; TIP120; TIP120 protein; TIP120A
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
  • 基因功能參考文獻：
    1. miR-33a and CAND1 played an important role in lung cancer proliferation and cell migration PMID: 28871425
    2. describe the identification of the structural determinants responsible for the CA IX/CAND1 interaction PMID: 28388044
    3. Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1), COP9 signalosome (CSN), neddylated cullin 3 (Cul3) and the BTB protein Keap1. PMID: 26219975
    4. The Epstein-Barr virus protein BPLF1, is targeted to cullin-RING ubiquitin ligases (CRLs) via the interaction of the conserved helix-2 with helix-23 of cullins, at a site involved in electrostatic interaction with CAND1. PMID: 22474075
    5. We demonstrate that the accumulation of p27 is associated with an increase of CAND1 and a decrease of Skp2 during adipogenesis of human LiSa-2 preadipocytes. CAND1 knockdown reduces p27 and blocks adipogenesis. PMID: 23328082
    6. Study shows that Cand1 can unambiguously stimulate SCF activity in vitro by enabling an F box protein-Skp1 complex to access Cul1 that was previously occupied by a different F box protein-Skp1 complex, and that Cand1 promotes assembly in vivo of new F box proteins with pre-existing Cul1 molecules. PMID: 23453757
    7. CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer. PMID: 23019411
    8. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. PMID: 21778237
    9. CAND1 does not function by sequestering cullins in vivo to prevent substrate receptor autoubiquitination and is likely to regulate cullin RING ligase activity via alternative mechanisms PMID: 21249194
    10. miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression. PMID: 20820187
    11. selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation PMID: 12504025
    12. binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex PMID: 12504026
    13. TIP120A functions as a negative regulator of SCF E3 ubiquitin ligases and may modulate other cullin ligases in a similar fashion. PMID: 12609982
    14. CAND1 & COP9 signalosome (CSN), major deneddylase of cullins, bind to unneddylated CUL1 in mutually exclusive way. Suppression of CAND1 expression by siRNA enhanced interaction between CUL1 & CSN, suggesting that CAND1 inhibited binding of CSN to CUL1. PMID: 16036220

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
  • 蛋白家族：
    CAND family
  • 數據庫鏈接：

    HGNC: 30688

    OMIM: 607727

    KEGG: hsa:55832

    STRING: 9606.ENSP00000299218

    UniGene: Hs.546407



主站蜘蛛池模板： 亚洲2020天天堂在线观看| 牛和人交xxxx欧美| 国产草莓精品国产av片国产| 国产高清乱理伦片| 亚洲国产码专区| 99久久亚洲精品无码毛片| 日日拍夜夜嗷嗷叫国产| 国产精品成人片在线观看| 日产精品中文一区二区三区| 激情内射亚洲一区二区三区| 国产精品www夜色视频| av网站免费线看精品| 日产2021免费一区| 久久久精品人妻一区二区三区四| 亚洲欧洲日产国码无码久久99| 伊人久久精品在热线热| 五月综合缴情婷婷六月| 大伊香蕉精品视频在线| 熟妇好大好深好满好爽| 野花社区在线www日本| 亚洲成αv人片在线观看| 亚洲午夜精品久久久久久app | 9l国产精品久久久久麻豆| 最新在线精品国自产拍福利| 桃花色综合影院| 亚洲aⅴ综合色区无码一区| 中国少妇内射xxxhd| 欧美群妇大交群| 中国少妇无码专区| 成人爽a毛片免费网站| 无码免费中文字幕视频| 精品久久香蕉国产线看观看亚洲| 亚洲中文字幕无码专区| 日日摸夜夜摸狠狠摸婷婷| 久久久久人妻一区精品| 97人人模人人爽人人喊网| 最新国产精品拍自在线观看| 小草国产精品情侣| 国产又大又黑又粗免费视频| 亚洲αⅴ无码乱码在线观看性色 | 99精品日本二区留学生|