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  4. CAND1 Antibody, HRP conjugated

CAND1 Antibody, HRP conjugated

  • 中文名稱：
    CAND1兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA774815LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CAND1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CAND1
  • 別名：
    CAND 1 antibody; Cand1 antibody; CAND1_HUMAN antibody; Cullin associated and neddylation dissociated 1 antibody; Cullin associated and neddylation dissociated protein 1 antibody; Cullin associated NEDD8 dissociated protein 1 antibody; Cullin-associated and neddylation-dissociated protein 1 antibody; Cullin-associated NEDD8-dissociated protein 1 antibody; DKFZP434M1414 antibody; FLJ10114 antibody; FLJ10929 antibody; FLJ38691 antibody; FLJ90441 antibody; KIAA0829 antibody; p120 CAND1 antibody; TATA binding protein interacting protein 120A antibody; TBP interacting protein antibody; TBP interacting protein of 120 kDa A antibody; TBP Interacting Protein TIP120A antibody; TBP-interacting protein 120A antibody; TBP-interacting protein of 120 kDa A antibody; TIP120 antibody; TIP120 protein antibody; TIP120A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cullin-associated NEDD8-dissociated protein 1 protein (1150-1230AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
  • 基因功能參考文獻(xiàn)：
    1. miR-33a and CAND1 played an important role in lung cancer proliferation and cell migration PMID: 28871425
    2. describe the identification of the structural determinants responsible for the CA IX/CAND1 interaction PMID: 28388044
    3. Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1), COP9 signalosome (CSN), neddylated cullin 3 (Cul3) and the BTB protein Keap1. PMID: 26219975
    4. The Epstein-Barr virus protein BPLF1, is targeted to cullin-RING ubiquitin ligases (CRLs) via the interaction of the conserved helix-2 with helix-23 of cullins, at a site involved in electrostatic interaction with CAND1. PMID: 22474075
    5. We demonstrate that the accumulation of p27 is associated with an increase of CAND1 and a decrease of Skp2 during adipogenesis of human LiSa-2 preadipocytes. CAND1 knockdown reduces p27 and blocks adipogenesis. PMID: 23328082
    6. Study shows that Cand1 can unambiguously stimulate SCF activity in vitro by enabling an F box protein-Skp1 complex to access Cul1 that was previously occupied by a different F box protein-Skp1 complex, and that Cand1 promotes assembly in vivo of new F box proteins with pre-existing Cul1 molecules. PMID: 23453757
    7. CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer. PMID: 23019411
    8. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. PMID: 21778237
    9. CAND1 does not function by sequestering cullins in vivo to prevent substrate receptor autoubiquitination and is likely to regulate cullin RING ligase activity via alternative mechanisms PMID: 21249194
    10. miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression. PMID: 20820187
    11. selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation PMID: 12504025
    12. binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex PMID: 12504026
    13. TIP120A functions as a negative regulator of SCF E3 ubiquitin ligases and may modulate other cullin ligases in a similar fashion. PMID: 12609982
    14. CAND1 & COP9 signalosome (CSN), major deneddylase of cullins, bind to unneddylated CUL1 in mutually exclusive way. Suppression of CAND1 expression by siRNA enhanced interaction between CUL1 & CSN, suggesting that CAND1 inhibited binding of CSN to CUL1. PMID: 16036220

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
  • 蛋白家族：
    CAND family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30688

    OMIM: 607727

    KEGG: hsa:55832

    STRING: 9606.ENSP00000299218

    UniGene: Hs.546407



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